1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	S	T	V	I	D	R	A	R	P	A	G	H	R	A	P	H	R	G	S	G	F	T	G	T	L	G	L	L	R	L	Y	L	R	R	D	R	V	S	L	P	L	W	V	L	L	L	S	V	P	L	A	T	V	Y	I	A	S	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	T	V	Y	P	D	R	S	A	R	A	A	A	A	A	A	I	M	A	S	P	A	Q	R	A	L	Y	G	P	V	Y	N	D	S	L	G	A	V	G	I	W	K	A	G	M	F	H	T	L	I	A	V	A	V	I	L	T	V	I	R
Secondary structure
SS confidence
Disorder				?	?	?	?													?							?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	T	R	A	D	E	E	S	G	R	A	E	L	I	D	S	T	V	V	G	R	Y	A	N	L	T	G	A	L	L	L	S	F	G	A	S	I	A	T	G	A	I	G	A	L	G	L	L	A	T	D	V	A	P	A	G	S	V	A	F
Secondary structure
SS confidence
Disorder																				?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	V	A	L	A	A	S	G	M	V	F	T	A	V	A	A	V	A	A	Q	L	S	P	S	A	R	F	T	R	A	V	A	F	A	V	L	G	T	A	F	A	L	R	A	I	G	D	A	G	S	G	T	L	S	W	C	S	P	L	G
Secondary structure
SS confidence
Disorder																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		W	S	L	Q	V	R	P	Y	A	G	E	R	W	W	V	L	L	L	S	L	A	T	A	A	V	L	T	V	L	A	Y	R	L	R	A	G	R	D	V	G	A	G	L	I	A	E	R	P	G	A	G	T	A	G	P	M	L	S	E	P
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	G	L	A	W	R	L	N	R	G	S	L	L	L	W	T	V	G	L	C	L	Y	G	L	V	M	G	S	V	V	H	G	I	G	D	Q	L	G	D	N	T	A	V	R	D	I	V	T	R	M	G	G	T	G	A	L	E	Q	A	F
Secondary structure
SS confidence
Disorder																																							?	?	?									?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	A	L	A	F	T	M	I	G	M	V	A	A	A	F	A	V	S	L	T	L	R	L	H	Q	E	E	T	G	L	R	A	E	T	L	L	A	G	A	V	S	R	T	H	W	L	A	S	H	L	A	M	A	L	A	G	S	A	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		T	L	I	S	G	V	A	A	G	L	A	Y	G	M	T	V	G	D	V	G	G	K	L	P	T	V	V	G	T	A	A	V	Q	L	P	A	V	W	L	L	S	A	V	T	V	G	L	F	G	L	A	P	R	F	T	P	V	A	W	G
Secondary structure
SS confidence
Disorder															?	?	?	?	?																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		V	L	V	G	F	I	A	L	Y	L	L	G	S	L	A	G	F	P	Q	M	L	L	N	L	E	P	F	A	H	I	P	R	V	G	G	G	D	F	T	A	V	P	L	L	W	L	L	A	I	D	A	A	L	I	T	L	G	A	M	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		F	R	R	R	D	V	R	C
Secondary structure
SS confidence
Disorder							?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 75%) Beta strand ( 0%) TM helix ( 48%) (View membrane topology prediction)

Rank Aligned region

PDB 6an7 chain D Region: 301 - 545 Aligned: 220 Modelled: 226 Confidence: 99.2% Identity: 10% PDB header:transport protein Chain: D: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 6an7 chain C Region: 346 - 545 Aligned: 194 Modelled: 200 Confidence: 99.1% Identity: 9% PDB header:transport protein Chain: C: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 5do7 chain A Region: 281 - 545 Aligned: 244 Modelled: 249 Confidence: 98.9% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family g member 5; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5do7 chain B Region: 290 - 547 Aligned: 235 Modelled: 240 Confidence: 98.9% Identity: 16% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 8; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5nj3 chain B Region: 303 - 544 Aligned: 218 Modelled: 223 Confidence: 98.4% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: complete structure Phyre2 PDB 5njg chain B Region: 20 - 277 Aligned: 230 Modelled: 231 Confidence: 98.4% Identity: 17% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: part of the structure that could be2 built de novo Phyre2 PDB 5xjy chain A Region: 353 - 543 Aligned: 184 Modelled: 191 Confidence: 95.8% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family a member 1; PDBTitle: cryo-em structure of human abca1 Phyre2 PDB 5ws4 chain A Region: 359 - 477 Aligned: 117 Modelled: 119 Confidence: 45.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: crystal structure of tripartite-type abc transporter macb from2 acinetobacter baumannii Phyre2 PDB 6elh chain A Region: 92 - 272 Aligned: 181 Modelled: 181 Confidence: 25.0% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:nitric-oxide reductase; PDBTitle: low resolution structure of neisseria meningitidis qnor Phyre2 PDB 6hwh chain X Region: 248 - 271 Aligned: 24 Modelled: 24 Confidence: 12.7% Identity: 29% PDB header:electron transport Chain: X: PDB Molecule:cytochrome c oxidase polypeptide 4; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 1ots chain A Region: 198 - 538 Aligned: 318 Modelled: 327 Confidence: 9.0% Identity: 16% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 1jqn chain A Region: 300 - 350 Aligned: 51 Modelled: 51 Confidence: 8.6% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Phosphoenolpyruvate carboxylase Phyre2 PDB 3hzq chain A Region: 309 - 387 Aligned: 77 Modelled: 79 Confidence: 7.8% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: structure of a tetrameric mscl in an expanded intermediate state Phyre2 PDB 2jp3 chain A Region: 527 - 548 Aligned: 22 Modelled: 22 Confidence: 7.6% Identity: 18% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 2jo1 chain A Region: 527 - 548 Aligned: 22 Modelled: 22 Confidence: 7.5% Identity: 36% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 5xu1 chain M Region: 359 - 466 Aligned: 108 Modelled: 108 Confidence: 7.4% Identity: 14% PDB header:transport protein Chain: M: PDB Molecule:abc transporter permeae; PDBTitle: structure of a non-canonical abc transporter from streptococcus2 pneumoniae r6 Phyre2 PDB 2mkv chain A Region: 527 - 548 Aligned: 22 Modelled: 22 Confidence: 7.3% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:sodium/potassium-transporting atpase subunit gamma; PDBTitle: structure of the na,k-atpase regulatory protein fxyd2b in micelles Phyre2 PDB 1atx chain A Region: 16 - 26 Aligned: 11 Modelled: 11 Confidence: 7.2% Identity: 36% Fold: Defensin-like Superfamily: Defensin-like Family: Defensin Phyre2 PDB 5lj7 chain B Region: 359 - 463 Aligned: 105 Modelled: 105 Confidence: 6.9% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:macrolide export atp-binding/permease protein macb; PDBTitle: structure of aggregatibacter actinomycetemcomitans macb bound to atp2 (p21) Phyre2 PDB 2h9x chain A Region: 10 - 26 Aligned: 17 Modelled: 17 Confidence: 6.9% Identity: 24% PDB header:toxin Chain: A: PDB Molecule:toxin cgna; PDBTitle: nmr structure for the cgna toxin from the sea anemone2 condylactis gigantea Phyre2 1 c6an7D_ 2 c6an7C_ 3 c5do7A_ 4 c5do7B_ 5 c5nj3B_ 6 c5njgB_ 7 c5xjyA_ 8 c5ws4A_ 9 c6elhA_ 10 c6hwhX_ 11 d1otsa_ 12 d1jqna_ 13 c3hzqA_ 14 c2jp3A_ 15 c2jo1A_ 16 c5xu1M_ 17 c2mkvA_ 18 d1atxa_ 19 c5lj7B_ 20 c2h9xA_ 21 22 23 24 25 26 27 28 29 30 31 32