1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	D	R	P	H	D	W	H	R	L	S	P	R	M	L	L	V	H	P	V	H	E	M	L	R	Q	L	P	V	L	I	G	S	V	V	L	G	S	A	T	G	N	P	V	W	P	L	A	A	L	G	V	T	V	V	F	G	V	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	W	F	F	T	T	Y	R	I	D	D	E	N	V	S	L	R	T	G	I	L	S	R	R	A	V	S	V	P	R	N	R	I	R	S	V	Q	T	E	A	R	L	L	H	R	L	L	G	L	T	V	L	R	V	G	T	G	Q	E	A
Secondary structure
SS confidence
Disorder																																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	G	E	A	A	F	E	L	D	A	V	D	S	A	R	V	P	R	L	R	A	L	L	L	A	E	S	L	A	P	V	E	P	T	G	R	V	L	A	R	W	Q	S	S	W	L	R	Y	A	P	L	S	F	S	G	L	V	M	I	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?																				?	?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	V	I	G	L	G	Y	Q	T	G	L	A	V	R	L	P	E	S	G	F	A	R	S	A	V	D	A	A	Q	R	A	G	V	V	L	V	V	A	V	T	V	L	L	V	V	G	V	S	A	L	L	A	V	L	F	S	W	L	T	Y
Secondary structure
SS confidence
Disorder											?	?	?	?	?				?								?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	N	L	L	L	R	R	G	G	S	G	Q	E	G	V	L	H	L	R	H	G	L	L	R	V	R	E	H	T	Y	D	M	R	R	L	R	G	A	T	L	R	E	P	L	L	V	R	L	L	R	G	A	R	L	D	A	V	M	T	G
Secondary structure
SS confidence
Disorder											?	?	?	?	?																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	H	G	E	G	Q	S	S	M	L	L	P	P	C	P	F	E	T	A	T	A	V	L	T	D	L	I	D	N	T	D	A	A	A	G	P	L	R	R	H	G	P	A	A	A	R	R	R	W	T	R	A	L	L	V	P	T	L	A	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	A	L	I	A	A	A	P	I	L	G	V	P	G	W	A	W	T	L	W	A	V	L	T	A	G	C	A	G	L	A	V	D	R	V	R	S	L	G	H	R	V	A	D	G	W	L	V	A	R	A	G	S	L	Q	R	R	R	D	C
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		I	A	C	T	G	I	I	G	W	T	V	R	Q	T	L	F	Q	R	R	A	G	V	A	T	L	V	A	A	T	V	A	G	R	K	G	Y	Q	V	L	D	V	P	A	E	L	A	W	S	V	A	G	A	A	S	P	W	V	A	D	S
Secondary structure
SS confidence
Disorder																															?		?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		V	W	L	R	H	G	S
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 46%) Beta strand ( 29%) TM helix ( 28%) (View membrane topology prediction)

Rank Aligned region

PDB 2gcl chain A domain 1 Region: 76 - 147 Aligned: 62 Modelled: 72 Confidence: 83.0% Identity: 15% Fold: PH domain-like barrel Superfamily: PH domain-like Family: SSRP1-like Phyre2 PDB 3dcx chain A domain 1 Region: 64 - 128 Aligned: 49 Modelled: 49 Confidence: 71.0% Identity: 20% Fold: PH domain-like barrel Superfamily: PH domain-like Family: BPHL domain Phyre2 PDB 3fss chain A Region: 74 - 146 Aligned: 65 Modelled: 72 Confidence: 66.5% Identity: 11% PDB header:chaperone Chain: A: PDB Molecule:histone chaperone rtt106; PDBTitle: structure of the tandem ph domains of rtt106 Phyre2 PDB 4tyz chain B Region: 402 - 477 Aligned: 70 Modelled: 76 Confidence: 66.1% Identity: 13% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the c-terminal domain of an unknown protein from2 leishmania infantum Phyre2 PDB 3gyp chain A Region: 76 - 147 Aligned: 64 Modelled: 72 Confidence: 37.2% Identity: 11% PDB header:chaperone Chain: A: PDB Molecule:histone chaperone rtt106; PDBTitle: rtt106p Phyre2 PDB 4khb chain F Region: 66 - 170 Aligned: 93 Modelled: 105 Confidence: 17.3% Identity: 13% PDB header:transcription/replication Chain: F: PDB Molecule:uncharacterized protein pob3n; PDBTitle: structure of the spt16d pob3n heterodimer Phyre2 PDB 1ujp chain A Region: 450 - 483 Aligned: 34 Modelled: 34 Confidence: 13.5% Identity: 24% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Tryptophan biosynthesis enzymes Phyre2 PDB 5tch chain G Region: 450 - 483 Aligned: 34 Modelled: 34 Confidence: 12.8% Identity: 24% PDB header:lyase Chain: G: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of tryptophan synthase from m. tuberculosis -2 ligand-free form, trpa-g66v mutant Phyre2 PDB 5k9x chain A Region: 451 - 483 Aligned: 33 Modelled: 33 Confidence: 9.7% Identity: 30% PDB header:lyase Chain: A: PDB Molecule:tryptophan synthase alpha chain; PDBTitle: crystal structure of tryptophan synthase alpha chain from legionella2 pneumophila subsp. pneumophila Phyre2 PDB 1lqv chain D Region: 478 - 487 Aligned: 10 Modelled: 10 Confidence: 8.8% Identity: 60% PDB header:blood clotting Chain: D: PDB Molecule:vitamin-k dependent protein c; PDBTitle: crystal structure of the endothelial protein c receptor with2 phospholipid in the groove in complex with gla domain of protein c. Phyre2 PDB 3jtc chain D Region: 478 - 487 Aligned: 10 Modelled: 10 Confidence: 8.8% Identity: 60% PDB header:blood clotting Chain: D: PDB Molecule:vitamin k-dependent protein c; PDBTitle: importance of mg2+ in the ca2+-dependent folding of the gamma-2 carboxyglutamic acid domains of vitamin k-dependent clotting and3 anticlotting proteins Phyre2 PDB 3jtc chain C Region: 478 - 487 Aligned: 10 Modelled: 10 Confidence: 8.8% Identity: 60% PDB header:blood clotting Chain: C: PDB Molecule:vitamin k-dependent protein c; PDBTitle: importance of mg2+ in the ca2+-dependent folding of the gamma-2 carboxyglutamic acid domains of vitamin k-dependent clotting and3 anticlotting proteins Phyre2 PDB 1lqv chain C Region: 478 - 487 Aligned: 10 Modelled: 10 Confidence: 8.8% Identity: 60% PDB header:blood clotting Chain: C: PDB Molecule:vitamin-k dependent protein c; PDBTitle: crystal structure of the endothelial protein c receptor with2 phospholipid in the groove in complex with gla domain of protein c. Phyre2 PDB 5umr chain A Region: 66 - 145 Aligned: 67 Modelled: 80 Confidence: 8.1% Identity: 10% PDB header:transcription Chain: A: PDB Molecule:fact complex subunit ssrp1; PDBTitle: crystal structure of n-terminal domain of human fact complex subunit2 ssrp1 Phyre2 PDB 5yqr chain A Region: 66 - 143 Aligned: 68 Modelled: 78 Confidence: 7.8% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:endolysin/membrane-anchored lipid-binding protein lam6 PDBTitle: crystal structure of the ph-like domain of lam6 Phyre2 PDB 5x3x chain Q Region: 5 - 63 Aligned: 52 Modelled: 59 Confidence: 7.8% Identity: 21% PDB header:transport protein Chain: Q: PDB Molecule:uncharacterized protein cbiq; PDBTitle: 2.8a resolution structure of a cobalt energy-coupling factor2 transporter-cbimqo Phyre2 PDB 1zj8 chain A domain 1 Region: 436 - 475 Aligned: 37 Modelled: 40 Confidence: 7.5% Identity: 22% Fold: Ferredoxin-like Superfamily: Nitrite/Sulfite reductase N-terminal domain-like Family: Duplicated SiR/NiR-like domains 1 and 3 Phyre2 PDB 5uz9 chain K Region: 64 - 79 Aligned: 16 Modelled: 16 Confidence: 7.3% Identity: 38% PDB header:immune system/rna Chain: K: PDB Molecule:anti-crispr protein 30; PDBTitle: cryo em structure of anti-crisprs, acrf1 and acrf2, bound to type i-f2 crrna-guided crispr surveillance complex Phyre2 PDB 3b77 chain A domain 1 Region: 104 - 128 Aligned: 25 Modelled: 25 Confidence: 6.6% Identity: 4% Fold: PH domain-like barrel Superfamily: PH domain-like Family: BPHL domain Phyre2 PDB 3f5r chain A Region: 78 - 145 Aligned: 59 Modelled: 68 Confidence: 6.5% Identity: 17% PDB header:transcription regulator Chain: A: PDB Molecule:fact complex subunit pob3; PDBTitle: the crystal structure of a subunit of the heterodimeric fact complex2 (spt16p-pob3p). Phyre2 1 d2gcla1 2 d3dcxa1 3 c3fssA_ 4 c4tyzB_ 5 c3gypA_ 6 c4khbF_ 7 d1ujpa_ 8 c5tchG_ 9 c5k9xA_ 10 c1lqvD_ 11 c3jtcD_ 12 c3jtcC_ 13 c1lqvC_ 14 c5umrA_ 15 c5yqrA_ 16 c5x3xq_ 17 d1zj8a1 18 c5uz9K_ 19 d3b77a1 20 c3f5rA_ 21 22 23 24 25 26 27 28 29