1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	A	R	R	A	T	Y	W	A	V	L	D	T	L	V	V	G	Y	A	L	L	P	V	L	W	I	F	S	L	S	L	K	P	T	S	T	V	K	D	G	K	L	I	P	S	T	V	T	F	D	N	Y	R	G	I	F	R	G	D
Secondary structure
SS confidence
Disorder		?	?	?	?																														?				?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	F	S	S	A	L	I	N	S	I	G	I	G	L	I	T	T	V	I	A	V	V	L	G	A	M	A	A	Y	A	V	A	R	L	E	F	P	G	K	R	L	L	I	G	A	A	L	L	I	T	M	F	P	S	I	S	L	V	T	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	F	N	I	E	R	A	I	G	L	F	D	T	W	P	G	L	I	L	P	Y	I	T	F	A	L	P	L	A	I	Y	T	L	S	A	F	F	R	E	I	P	W	D	L	E	K	A	A	K	M	D	G	A	T	P	G	Q	A	F	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	V	I	V	P	L	A	A	P	G	L	V	T	A	A	I	L	V	F	I	F	A	W	N	D	L	L	L	A	L	S	L	T	A	T	K	A	A	I	T	A	P	V	A	I	A	N	F	T	G	S	S	Q	F	E	E	P	T	G	S
Secondary structure
SS confidence
Disorder																																					?	?	?											?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.
Sequence		I	A	A	G	A	I	V	I	T	I	P	I	I	V	F	V	L	I	F	Q	R	R	I	V	A	G	L	T	S	G	A	V	K	G
Secondary structure
SS confidence
Disorder																													?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 50%) (View membrane topology prediction)

Rank Aligned region

PDB 2r6g chain G domain 1 Region: 2 - 274 Aligned: 270 Modelled: 273 Confidence: 100.0% Identity: 31% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 4tqv chain J Region: 2 - 267 Aligned: 262 Modelled: 266 Confidence: 100.0% Identity: 25% PDB header:transport protein Chain: J: PDB Molecule:algm2; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 3fh6 chain F Region: 3 - 261 Aligned: 259 Modelled: 259 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 4tqv chain I Region: 3 - 265 Aligned: 254 Modelled: 262 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: I: PDB Molecule:algm1; PDBTitle: crystal structure of a bacterial abc transporter involved in the2 import of the acidic polysaccharide alginate Phyre2 PDB 2r6g chain F Region: 41 - 258 Aligned: 218 Modelled: 218 Confidence: 100.0% Identity: 22% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 2onk chain C domain 1 Region: 1 - 261 Aligned: 240 Modelled: 246 Confidence: 100.0% Identity: 21% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C Region: 1 - 261 Aligned: 240 Modelled: 246 Confidence: 100.0% Identity: 21% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 2r6g chain F domain 2 Region: 50 - 258 Aligned: 209 Modelled: 209 Confidence: 100.0% Identity: 24% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain C domain 1 Region: 6 - 260 Aligned: 235 Modelled: 237 Confidence: 100.0% Identity: 21% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain D Region: 6 - 260 Aligned: 235 Modelled: 237 Confidence: 100.0% Identity: 21% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease protein; PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 4ymu chain C Region: 49 - 265 Aligned: 211 Modelled: 217 Confidence: 99.9% Identity: 17% PDB header:protein binding/transport protein Chain: C: PDB Molecule:abc-type amino acid transport system, permease component; PDBTitle: crystal structure of an amino acid abc transporter complex with2 arginines and atps Phyre2 PDB 3dhw chain A domain 1 Region: 62 - 258 Aligned: 190 Modelled: 197 Confidence: 99.9% Identity: 18% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 5kbu chain A Region: 64 - 186 Aligned: 84 Modelled: 84 Confidence: 78.5% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:glutamate receptor 2,voltage-dependent calcium channel PDBTitle: cryo-em structure of glua2-2xstz complex at 7.8 angstrom resolution Phyre2 PDB 2r6g chain F domain 1 Region: 4 - 37 Aligned: 34 Modelled: 34 Confidence: 75.2% Identity: 18% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 2hx6 chain A Region: 151 - 177 Aligned: 27 Modelled: 27 Confidence: 30.8% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease; PDBTitle: solution structure analysis of the phage t42 endoribonuclease regb Phyre2 PDB 2jwa chain A Region: 67 - 100 Aligned: 34 Modelled: 34 Confidence: 27.9% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure Phyre2 PDB 2ks1 chain A Region: 67 - 100 Aligned: 34 Modelled: 34 Confidence: 27.9% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: heterodimeric association of transmembrane domains of erbb1 and erbb22 receptors enabling kinase activation Phyre2 PDB 2m8g chain X Region: 152 - 175 Aligned: 24 Modelled: 24 Confidence: 21.5% Identity: 21% PDB header:transcription Chain: X: PDB Molecule:transcriptional regulator; PDBTitle: structure, function, and tethering of dna-binding domains in 542 transcriptional activators Phyre2 PDB 4l5e chain A Region: 152 - 175 Aligned: 24 Modelled: 24 Confidence: 16.9% Identity: 13% PDB header:protein binding Chain: A: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of a. aeolicus ntrc1 dna binding domain Phyre2 PDB 1umq chain A Region: 152 - 175 Aligned: 24 Modelled: 24 Confidence: 14.8% Identity: 4% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 1 d2r6gg1 2 c4tqvJ_ 3 c3fh6F_ 4 c4tqvI_ 5 c2r6gF_ 6 d2onkc1 7 c2onkC_ 8 d2r6gf2 9 d3d31c1 10 c3d31D_ 11 c4ymuC_ 12 d3dhwa1 13 c5kbuA_ 14 d2r6gf1 15 c2hx6A_ 16 c2jwaA_ 17 c2ks1A_ 18 c2m8gX_ 19 c4l5eA_ 20 d1umqa_ 21 22 23 24 25 26 27 28 29 30 31 32 33