1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	D	D	H	P	Y	H	V	A	I	T	A	T	A	A	R	D	L	Q	R	L	P	E	K	I	A	A	A	C	V	E	F	V	F	G	P	L	L	N	N	P	H	R	L	G	K	P	L	R	N	D	L	E	G	L	H	S	A	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?															?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.
Sequence		R	G	D	Y	R	V	V	Y	A	I	D	D	G	H	H	R	V	E	I	I	H	I	A	R	R	S	A	S	Y	R	M	N	P	C	R	P	R
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 35%) Beta strand ( 35%)

Rank Aligned region

PDB 3g5o chain C Region: 6 - 87 Aligned: 82 Modelled: 82 Confidence: 99.9% Identity: 54% PDB header:toxin/antitoxin Chain: C: PDB Molecule:uncharacterized protein rv2866; PDBTitle: the crystal structure of the toxin-antitoxin complex relbe2 (rv2865-2 2866) from mycobacterium tuberculosis Phyre2 PDB 3bpq chain D Region: 9 - 93 Aligned: 82 Modelled: 85 Confidence: 99.9% Identity: 17% PDB header:toxin Chain: D: PDB Molecule:toxin rele3; PDBTitle: crystal structure of relb-rele antitoxin-toxin complex from2 methanococcus jannaschii Phyre2 PDB 2khe chain A Region: 1 - 90 Aligned: 86 Modelled: 86 Confidence: 99.9% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:toxin-like protein; PDBTitle: solution structure of the bacterial toxin rele from thermus2 thermophilus hb8 Phyre2 PDB 3kix chain Y Region: 7 - 96 Aligned: 89 Modelled: 90 Confidence: 99.9% Identity: 20% PDB header:ribosome Chain: Y: PDB Molecule: PDBTitle: structure of rele nuclease bound to the 70s ribosome (postcleavage2 state; part 3 of 4) Phyre2 PDB 1wmi chain A domain 1 Region: 6 - 88 Aligned: 82 Modelled: 83 Confidence: 99.9% Identity: 29% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 2otr chain A Region: 6 - 89 Aligned: 84 Modelled: 84 Confidence: 99.6% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein hp0892; PDBTitle: solution structure of conserved hypothetical protein hp0892 from2 helicobacter pylori Phyre2 PDB 3oei chain H Region: 6 - 85 Aligned: 77 Modelled: 80 Confidence: 99.4% Identity: 25% PDB header:toxin, protein binding Chain: H: PDB Molecule:relk (toxin rv3358); PDBTitle: crystal structure of mycobacterium tuberculosis reljk (rv3357-rv3358-2 relbe3) Phyre2 PDB 2a6s chain A domain 1 Region: 8 - 85 Aligned: 75 Modelled: 78 Confidence: 99.3% Identity: 21% Fold: RelE-like Superfamily: RelE-like Family: YoeB/Txe-like Phyre2 PDB 1z8m chain A domain 1 Region: 6 - 89 Aligned: 82 Modelled: 82 Confidence: 99.1% Identity: 15% Fold: RelE-like Superfamily: RelE-like Family: RelE-like Phyre2 PDB 4q2u chain H Region: 6 - 89 Aligned: 82 Modelled: 84 Confidence: 98.9% Identity: 15% PDB header:toxin/toxin repressor Chain: H: PDB Molecule:mrna interferase yafq; PDBTitle: crystal structure of the e. coli dinj-yafq toxin-antitoxin complex Phyre2 PDB 5ceg chain B Region: 6 - 84 Aligned: 78 Modelled: 79 Confidence: 98.3% Identity: 17% PDB header:toxin Chain: B: PDB Molecule:plasmid stabilization system; PDBTitle: x-ray structure of toxin/anti-toxin complex from mesorhizobium2 opportunistum Phyre2 PDB 5cw7 chain H Region: 6 - 84 Aligned: 76 Modelled: 78 Confidence: 98.0% Identity: 20% PDB header:toxin Chain: H: PDB Molecule:plasmid stabilization protein pare; PDBTitle: crystal structure of the paaa2-pare2 antitoxin-toxin complex Phyre2 PDB 3kxe chain B Region: 8 - 84 Aligned: 73 Modelled: 77 Confidence: 97.8% Identity: 27% PDB header:protein binding Chain: B: PDB Molecule:toxin protein pare-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex Phyre2 PDB 4mct chain D Region: 20 - 82 Aligned: 61 Modelled: 63 Confidence: 97.4% Identity: 18% PDB header:toxin Chain: D: PDB Molecule:killer protein; PDBTitle: p. vulgaris higba structure, crystal form 1 Phyre2 PDB 5ja9 chain D Region: 12 - 82 Aligned: 66 Modelled: 71 Confidence: 96.9% Identity: 17% PDB header:toxin Chain: D: PDB Molecule:toxin higb-2; PDBTitle: crystal structure of the higb2 toxin in complex with nb6 Phyre2 PDB 6f8s chain D Region: 24 - 78 Aligned: 50 Modelled: 55 Confidence: 94.1% Identity: 14% PDB header:toxin Chain: D: PDB Molecule:putative killer protein; PDBTitle: toxin-antitoxin complex grata Phyre2 PDB 5ifg chain C Region: 10 - 87 Aligned: 78 Modelled: 78 Confidence: 80.2% Identity: 15% PDB header:hydrolase/antitoxin Chain: C: PDB Molecule:mrna interferase higb; PDBTitle: crystal structure of higa-higb complex from e. coli Phyre2 PDB 2kru chain A Region: 8 - 44 Aligned: 37 Modelled: 37 Confidence: 60.5% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:light-independent protochlorophyllide reductase subunit b; PDBTitle: solution nmr structure of the pcp_red domain of light-independent2 protochlorophyllide reductase subunit b from chlorobium tepidum.3 northeast structural genomics consortium target ctr69a Phyre2 PDB 2l09 chain A Region: 8 - 44 Aligned: 37 Modelled: 37 Confidence: 50.9% Identity: 11% PDB header:oxidoreductase Chain: A: PDB Molecule:asr4154 protein; PDBTitle: solution nmr structure of protein asr4154 from nostoc sp. pcc71202 northeast structural genomics consortium target id nsr143 Phyre2 PDB 6avh chain A Region: 49 - 84 Aligned: 36 Modelled: 36 Confidence: 38.5% Identity: 19% PDB header:ligase, plant protein Chain: A: PDB Molecule:gh3.15 acyl acid amido synthetase; PDBTitle: gh3.15 acyl acid amido synthetase Phyre2 1 c3g5oC_ 2 c3bpqD_ 3 c2kheA_ 4 c3kixy_ 5 d1wmia1 6 c2otrA_ 7 c3oeiH_ 8 d2a6sa1 9 d1z8ma1 10 c4q2uH_ 11 c5cegB_ 12 c5cw7H_ 13 c3kxeB_ 14 c4mctD_ 15 c5ja9D_ 16 c6f8sD_ 17 c5ifgC_ 18 c2kruA_ 19 c2l09A_ 20 c6avhA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41