1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	L	P	K	E	R	A	A	Q	G	G	L	E	R	I	A	H	V	D	R	V	A	S	L	T	G	I	R	A	V	A	A	L	L	V	V	G	T	H	A	A	Y	T	T	G	K	Y	T	H	G	Y	W	G	L	M	S	S	R	M
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																									?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	I	G	V	P	I	F	F	V	L	S	G	F	L	L	F	R	P	W	V	K	S	A	A	T	G	G	P	P	P	S	L	S	R	Y	A	W	H	R	V	R	R	I	M	P	A	Y	T	V	T	V	L	L	A	Y	L	V	Y	H	F
Secondary structure
SS confidence
Disorder																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	T	A	G	P	N	P	G	H	T	W	V	G	L	F	R	N	L	T	L	T	Q	I	Y	T	D	G	Y	L	G	A	F	L	H	Q	G	L	T	Q	M	W	S	L	A	V	E	V	A	F	Y	L	A	L	P	A	L	A	Y	L	L
Secondary structure
SS confidence
Disorder					?	?	?	?																			?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	V	L	V	C	R	R	R	W	Q	P	R	L	L	L	A	T	M	A	G	L	T	M	I	S	P	A	W	L	I	L	V	H	N	T	H	W	M	P	D	G	A	R	L	W	L	P	T	Y	L	A	W	F	V	G	G	M	M	L	A
Secondary structure
SS confidence
Disorder							?	?																												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	L	A	A	M	G	V	R	C	Y	A	F	V	A	I	P	L	A	V	I	C	Y	F	I	V	S	T	P	I	A	G	A	P	T	T	S	P	T	A	L	A	E	A	L	V	K	T	A	F	Y	A	V	I	A	V	L	A	V	A	P
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?																			?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	A	L	G	D	Q	G	W	Y	A	Q	L	L	A	S	R	P	M	V	F	L	G	E	I	S	Y	E	I	F	L	I	H	L	V	T	M	E	I	A	M	V	D	V	L	G	Y	R	V	Y	T	S	S	M	V	N	L	C	L	V	T
Secondary structure
SS confidence
Disorder																																														?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.
Sequence		L	V	L	T	I	P	L	A	W	L	L	H	R	F	T	R	V	Q	G	D	R	P	S
Secondary structure
SS confidence
Disorder																					?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 37%) (View membrane topology prediction)

Rank Aligned region

PDB 3bbo chain 2 Region: 1 - 11 Aligned: 11 Modelled: 11 Confidence: 16.9% Identity: 36% PDB header:ribosome Chain: 2: PDB Molecule:ribosomal protein l32; PDBTitle: homology model for the spinach chloroplast 50s subunit fitted to 9.4a2 cryo-em map of the 70s chlororibosome Phyre2 PDB 2wwb chain B Region: 318 - 335 Aligned: 18 Modelled: 18 Confidence: 12.6% Identity: 28% PDB header:ribosome Chain: B: PDB Molecule:protein transport protein sec61 subunit gamma; PDBTitle: cryo-em structure of the mammalian sec61 complex bound to the actively2 translating wheat germ 80s ribosome Phyre2 PDB 4gn0 chain D Region: 353 - 381 Aligned: 29 Modelled: 29 Confidence: 12.0% Identity: 7% PDB header:signaling protein Chain: D: PDB Molecule:hamp domain of af1503; PDBTitle: de novo phasing of a hamp-complex using an improved arcimboldo method Phyre2 PDB 1ujl chain A Region: 9 - 28 Aligned: 20 Modelled: 20 Confidence: 9.1% Identity: 25% PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily h PDBTitle: solution structure of the herg k+ channel s5-p2 extracellular linker Phyre2 PDB 5jef chain A Region: 353 - 381 Aligned: 29 Modelled: 29 Confidence: 9.1% Identity: 3% PDB header:transferase Chain: A: PDB Molecule:nitrate/nitrite sensor protein narq; PDBTitle: fragment of nitrate/nitrite sensor histidine kinase narq (wt) in2 asymmetric holo state Phyre2 PDB 1rhz chain B Region: 318 - 335 Aligned: 18 Modelled: 18 Confidence: 8.7% Identity: 28% Fold: Single transmembrane helix Superfamily: Preprotein translocase SecE subunit Family: Preprotein translocase SecE subunit Phyre2 PDB 2m6i chain C Region: 10 - 128 Aligned: 89 Modelled: 89 Confidence: 7.5% Identity: 15% PDB header:membrane protein Chain: C: PDB Molecule:full-length transmembrane domains of human glycine receptor PDBTitle: putative pentameric open-channel structure of full-length2 transmembrane domains of human glycine receptor alpha1 subunit Phyre2 PDB 1yc6 chain 1 domain 1 Region: 1 - 22 Aligned: 20 Modelled: 22 Confidence: 6.7% Identity: 35% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Positive stranded ssRNA viruses Family: Bromoviridae-like VP Phyre2 PDB 1ijd chain B Region: 25 - 48 Aligned: 24 Modelled: 24 Confidence: 6.5% Identity: 17% Fold: Light-harvesting complex subunits Superfamily: Light-harvesting complex subunits Family: Light-harvesting complex subunits Phyre2 PDB 3bz6 chain A domain 2 Region: 7 - 26 Aligned: 20 Modelled: 20 Confidence: 6.4% Identity: 20% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: PSPTO2686-like Phyre2 PDB 1m5w chain A Region: 4 - 25 Aligned: 22 Modelled: 22 Confidence: 6.3% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Pyridoxine 5'-phosphate synthase Family: Pyridoxine 5'-phosphate synthase Phyre2 PDB 3j1r chain H Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: H: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain R Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: R: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain P Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: P: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain S Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: S: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain G Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: G: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain E Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: E: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain N Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: N: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain F Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: F: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 PDB 3j1r chain D Region: 352 - 376 Aligned: 25 Modelled: 25 Confidence: 6.2% Identity: 24% PDB header:cell adhesion, structural protein Chain: D: PDB Molecule:archaeal adhesion filament core; PDBTitle: filaments from ignicoccus hospitalis show diversity of packing in2 proteins containing n-terminal type iv pilin helices Phyre2 1 c3bbo2_ 2 c2wwbB_ 3 c4gn0D_ 4 c1ujlA_ 5 c5jefA_ 6 d1rhzb_ 7 c2m6iC_ 8 d1yc611 9 d1ijdb_ 10 d3bz6a2 11 d1m5wa_ 12 c3j1rH_ 13 c3j1rR_ 14 c3j1rP_ 15 c3j1rS_ 16 c3j1rG_ 17 c3j1rE_ 18 c3j1rN_ 19 c3j1rF_ 20 c3j1rD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52