1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	N	S	N	R	G	P	A	F	L	I	L	F	A	T	L	M	A	A	A	G	D	G	V	S	I	V	A	F	P	W	L	V	L	Q	R	E	G	S	A	G	Q	A	S	I	V	A	S	A	T	M	L	P	L	L	F	A	T	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	G	T	A	V	D	Y	F	G	R	R	R	V	S	M	V	A	D	A	L	S	G	A	A	V	A	G	V	P	L	V	A	W	G	Y	G	G	D	A	V	N	V	L	V	L	A	V	L	A	A	L	A	A	A	F	G	P	A	G
Secondary structure
SS confidence
Disorder																																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	T	A	R	D	S	M	L	P	E	A	A	A	R	A	G	W	S	L	D	R	I	N	G	A	Y	E	A	I	L	N	L	A	F	I	V	G	P	A	I	G	G	L	M	I	A	T	V	G	G	I	T	T	M	W	I	T	A	T	A
Secondary structure
SS confidence
Disorder			?								?					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	G	L	S	I	L	A	I	A	A	L	Q	L	E	G	A	G	K	P	H	H	T	S	R	P	Q	G	L	V	S	G	I	A	E	G	L	R	F	V	W	N	L	R	V	L	R	T	L	G	M	I	D	L	T	V	T	A	L	Y	L
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	M	E	S	V	L	F	P	K	Y	F	T	D	H	Q	Q	P	V	Q	L	G	W	A	L	M	A	I	A	G	G	G	L	V	G	A	L	G	Y	A	V	L	A	I	R	V	P	R	R	V	T	M	S	T	A	V	L	T	L	G	L
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	S	M	V	I	A	F	L	P	P	L	P	V	I	M	V	L	C	A	V	V	G	L	V	Y	G	P	I	Q	P	I	Y	N	Y	V	I	Q	T	R	A	A	Q	H	L	R	G	R	V	V	G	V	M	T	S	L	A	Y	A	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.
Sequence		P	L	G	L	L	L	A	G	P	L	T	D	A	A	G	L	H	A	T	F	L	A	L	A	L	P	I	V	C	T	G	L	V	A	I	R	L	P	A	L	R	E	L	D	L	A	P	Q	A	D	I	D	R	P	V	G	S	A	Q
Secondary structure
SS confidence
Disorder																																											?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 59%) (View membrane topology prediction)

Rank Aligned region

PDB 3wdo chain A Region: 1 - 417 Aligned: 402 Modelled: 417 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 1pv7 chain A Region: 1 - 413 Aligned: 413 Modelled: 413 Confidence: 100.0% Identity: 11% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 1pv7 chain B Region: 1 - 413 Aligned: 413 Modelled: 413 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:lactose permease; PDBTitle: crystal structure of lactose permease with tdg Phyre2 PDB 1pw4 chain A Region: 2 - 414 Aligned: 408 Modelled: 413 Confidence: 100.0% Identity: 13% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 6e9o chain A Region: 2 - 403 Aligned: 391 Modelled: 402 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 5ayn chain A Region: 7 - 400 Aligned: 387 Modelled: 387 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 39 (iron-regulated transporter); PDBTitle: crystal structure of a bacterial homologue of iron transporter2 ferroportin in outward-facing state Phyre2 PDB 4j05 chain A Region: 5 - 413 Aligned: 406 Modelled: 409 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 5aym chain A Region: 7 - 400 Aligned: 380 Modelled: 380 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 39 (iron-regulated transporter); PDBTitle: crystal structure of a bacterial homologue of iron transporter2 ferroportin in outward-facing state with soaked iron Phyre2 PDB 4zp0 chain A Region: 1 - 399 Aligned: 385 Modelled: 399 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 6gs7 chain A Region: 4 - 402 Aligned: 392 Modelled: 399 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4iky chain A Region: 4 - 402 Aligned: 391 Modelled: 399 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 4lds chain B Region: 9 - 401 Aligned: 383 Modelled: 391 Confidence: 100.0% Identity: 13% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 4w6v chain A Region: 1 - 403 Aligned: 397 Modelled: 397 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 4cl5 chain B Region: 2 - 407 Aligned: 406 Modelled: 406 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 6exs chain A Region: 4 - 402 Aligned: 391 Modelled: 399 Confidence: 100.0% Identity: 9% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 6g9x chain B Region: 9 - 403 Aligned: 364 Modelled: 376 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 4aps chain B Region: 5 - 397 Aligned: 384 Modelled: 393 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 5c65 chain A Region: 9 - 407 Aligned: 392 Modelled: 399 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 2gfp chain A Region: 9 - 390 Aligned: 368 Modelled: 379 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 6h7d chain A Region: 10 - 407 Aligned: 388 Modelled: 398 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 1 c3wdoA_ 2 d1pv7a_ 3 c1pv7B_ 4 d1pw4a_ 5 c6e9oA_ 6 c5aynA_ 7 c4j05A_ 8 c5aymA_ 9 c4zp0A_ 10 c6gs7A_ 11 c4ikyA_ 12 c4ldsB_ 13 c4w6vA_ 14 c4cl5B_ 15 c6exsA_ 16 c6g9xB_ 17 c4apsB_ 18 c5c65A_ 19 c2gfpA_ 20 c6h7dA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55