1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	I	A	A	E	S	S	A	K	P	V	W	G	P	P	N	F	C	A	A	A	A	R	M	Q	D	V	R	V	L	M	H	P	K	T	G	R	A	F	R	S	P	V	E	P	G	S	G	W	P	G	D	P	A	T	P	Q	T	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	A	D	A	A	Q	V	S	A	L	A	G	G	A	G	S	I	C	E	L	N	A	L	I	S	V	C	R	A	C	P	R	L	V	S	W	R	E	E	V	A	V	V	K	R	R	A	F	A	D	Q	P	Y	W	G	R	P	V	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																										?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	W	G	S	K	R	P	R	L	L	I	L	G	L	A	P	A	A	H	G	A	N	R	T	G	R	M	F	T	G	D	R	S	G	D	Q	L	Y	A	A	L	H	R	A	G	L	V	N	S	P	V	S	V	D	A	A	D	G	L	R
Secondary structure
SS confidence
Disorder																			?	?	?	?																													?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	N	R	I	R	I	T	A	P	V	R	C	A	P	P	G	N	S	P	T	P	A	E	R	L	T	C	S	P	W	L	N	A	E	W	R	L	V	S	D	H	I	R	A	I	V	A	L	G	G	F	A	W	Q	V	A	L	R	L	A
Secondary structure
SS confidence
Disorder																		?	?	?	?																																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.
Sequence		G	A	S	G	T	P	K	P	R	F	G	H	G	V	V	T	E	L	G	A	G	V	R	L	L	G	C	Y	H	P	S	Q	Q	N	M	F	T	G	R	L	T	P	T	M	L	D	D	I	F	R	E	A	K	K	L	A	G	I	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?																														?																					?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 38%) Alpha helix ( 28%) Beta strand ( 10%)

Rank Aligned region

PDB 2d3y chain A Region: 77 - 298 Aligned: 217 Modelled: 222 Confidence: 100.0% Identity: 48% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: crystal structure of uracil-dna glycosylase from thermus thermophilus2 hb8 Phyre2 PDB 6ajr chain A Region: 66 - 298 Aligned: 193 Modelled: 215 Confidence: 100.0% Identity: 26% PDB header:dna binding protein Chain: A: PDB Molecule:uracil dna glycosylase superfamily protein; PDBTitle: complex form of uracil dna glycosylase x and uracil Phyre2 PDB 4zbz chain A Region: 76 - 297 Aligned: 184 Modelled: 205 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: family 4 uracil-dna glycosylase from sulfolobus tokodaii (free form,2 x-ray wavelength=1.5418) Phyre2 PDB 1ui0 chain A Region: 77 - 298 Aligned: 181 Modelled: 205 Confidence: 100.0% Identity: 31% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Mug-like Phyre2 PDB 1vk2 chain A Region: 78 - 295 Aligned: 178 Modelled: 200 Confidence: 100.0% Identity: 29% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Mug-like Phyre2 PDB 3ikb chain B Region: 74 - 296 Aligned: 186 Modelled: 207 Confidence: 100.0% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized conserved protein; PDBTitle: the structure of a conserved protein from streptococcus2 mutans ua159. Phyre2 PDB 2rba chain B Region: 119 - 299 Aligned: 176 Modelled: 181 Confidence: 100.0% Identity: 16% PDB header:hydrolase/dna Chain: B: PDB Molecule:g/t mismatch-specific thymine dna glycosylase; PDBTitle: structure of human thymine dna glycosylase bound to abasic and2 undamaged dna Phyre2 PDB 2c2p chain A Region: 92 - 296 Aligned: 178 Modelled: 188 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:g/u mismatch-specific dna glycosylase; PDBTitle: the crystal structure of mismatch specific uracil-dna2 glycosylase (mug) from deinococcus radiodurans Phyre2 PDB 1mug chain A Region: 119 - 291 Aligned: 160 Modelled: 173 Confidence: 100.0% Identity: 16% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Mug-like Phyre2 PDB 2d07 chain A Region: 110 - 299 Aligned: 183 Modelled: 190 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:g/t mismatch-specific thymine dna glycosylase; PDBTitle: crystal structure of sumo-3-modified thymine-dna glycosylase Phyre2 PDB 5h93 chain C Region: 122 - 287 Aligned: 137 Modelled: 149 Confidence: 99.6% Identity: 24% PDB header:hydrolase Chain: C: PDB Molecule:geobacter metallireducens smug1; PDBTitle: crystal structure of geobacter metallireducens smug1 Phyre2 PDB 1oe4 chain A Region: 122 - 292 Aligned: 145 Modelled: 156 Confidence: 99.4% Identity: 21% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Single-strand selective monofunctional uracil-DNA glycosylase SMUG1 Phyre2 PDB 5h0j chain A Region: 122 - 295 Aligned: 150 Modelled: 160 Confidence: 98.7% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of wt pedobacter heparinus smug2 Phyre2 PDB 2l3f chain A Region: 116 - 290 Aligned: 152 Modelled: 157 Confidence: 97.4% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of a putative uracil dna glycosylase from2 methanosarcina acetivorans, northeast structural genomics consortium3 target mvr76 Phyre2 PDB 5grk chain A Region: 121 - 252 Aligned: 115 Modelled: 131 Confidence: 97.2% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:blr0248 protein; PDBTitle: crystal structure of uracil dna glycosylase -xanthine complex from2 bradyrhizobium diazoefficiens Phyre2 PDB 1lau chain E Region: 128 - 274 Aligned: 127 Modelled: 128 Confidence: 92.8% Identity: 13% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 PDB 3eug chain A Region: 126 - 278 Aligned: 133 Modelled: 153 Confidence: 92.0% Identity: 17% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 PDB 2j8x chain A domain 1 Region: 128 - 279 Aligned: 132 Modelled: 152 Confidence: 91.3% Identity: 19% Fold: Uracil-DNA glycosylase-like Superfamily: Uracil-DNA glycosylase-like Family: Uracil-DNA glycosylase Phyre2 PDB 5nn7 chain A Region: 128 - 278 Aligned: 131 Modelled: 151 Confidence: 90.8% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: kshv uracil-dna glycosylase, apo form Phyre2 PDB 3cxm chain A Region: 126 - 278 Aligned: 134 Modelled: 141 Confidence: 90.1% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:uracil-dna glycosylase; PDBTitle: leishmania naiffi uracil-dna glycosylase in complex with 5-bromouracil Phyre2 1 c2d3yA_ 2 c6ajrA_ 3 c4zbzA_ 4 d1ui0a_ 5 d1vk2a_ 6 c3ikbB_ 7 c2rbaB_ 8 c2c2pA_ 9 d1muga_ 10 c2d07A_ 11 c5h93C_ 12 d1oe4a_ 13 c5h0jA_ 14 c2l3fA_ 15 c5grkA_ 16 d1laue_ 17 d3euga_ 18 d2j8xa1 19 c5nn7A_ 20 c3cxmA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53