1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	C	V	F	C	A	I	I	A	G	E	A	P	A	I	R	I	Y	E	D	G	G	Y	L	A	I	L	D	I	R	P	F	T	R	G	H	T	L	V	L	P	K	R	H	T	V	D	L	T	D	T	P	P	E	A	L	A	D	M
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	I	G	Q	R	I	A	R	A	A	R	A	T	K	L	A	D	A	T	H	I	A	I	N	D	G	R	A	A	F	Q	T	V	F	H	V	H	L	H	V	L	P	P	R	N	G	D	K	L	S	V	A	K	G	M	M	L	R	R
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.
Sequence		D	P	D	R	E	A	T	G	R	I	L	R	E	A	L	A	Q	Q	D	A	A	A	Q	D
Secondary structure
SS confidence
Disorder																			?			?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 33%) Beta strand ( 21%)

Rank Aligned region

PDB 3l7x chain A Region: 2 - 136 Aligned: 135 Modelled: 135 Confidence: 100.0% Identity: 33% PDB header:cell cycle Chain: A: PDB Molecule:putative hit-like protein involved in cell-cycle PDBTitle: the crystal structure of smu.412c from streptococcus mutans ua159 Phyre2 PDB 3o0m chain B Region: 2 - 141 Aligned: 134 Modelled: 140 Confidence: 100.0% Identity: 75% PDB header:hydrolase Chain: B: PDB Molecule:hit family protein; PDBTitle: crystal structure of a zn-bound histidine triad family protein from2 mycobacterium smegmatis Phyre2 PDB 2eo4 chain A Region: 3 - 144 Aligned: 142 Modelled: 142 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:150aa long hypothetical histidine triad nucleotide-binding PDBTitle: crystal structure of hypothetical histidine triad nucleotide-binding2 protein st2152 from sulfolobus tokodaii strain7 Phyre2 PDB 3p0t chain B Region: 1 - 138 Aligned: 133 Modelled: 138 Confidence: 100.0% Identity: 29% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an hit-like protein from mycobacterium2 paratuberculosis Phyre2 PDB 6iq1 chain A Region: 2 - 139 Aligned: 138 Modelled: 138 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:adenosine 5'-monophosphoramidase; PDBTitle: crystal structure of histidine triad nucleotide-binding protein from2 candida albicans Phyre2 PDB 3ksv chain A Region: 2 - 138 Aligned: 137 Modelled: 137 Confidence: 100.0% Identity: 30% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: hypothetical protein from leishmania major Phyre2 PDB 3lb5 chain B Region: 2 - 135 Aligned: 129 Modelled: 134 Confidence: 100.0% Identity: 33% PDB header:cell cycle Chain: B: PDB Molecule:hit-like protein involved in cell-cycle regulation; PDBTitle: crystal structure of hit-like protein involved in cell-cycle2 regulation from bartonella henselae with unknown ligand Phyre2 PDB 3ano chain A Region: 1 - 138 Aligned: 134 Modelled: 138 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:ap-4-a phosphorylase; PDBTitle: crystal structure of a novel diadenosine 5',5'''-p1,p4-tetraphosphate2 phosphorylase from mycobacterium tuberculosis h37rv Phyre2 PDB 3imi chain B Region: 2 - 139 Aligned: 138 Modelled: 138 Confidence: 100.0% Identity: 33% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hit family protein; PDBTitle: 2.01 angstrom resolution crystal structure of a hit family protein2 from bacillus anthracis str. 'ames ancestor' Phyre2 PDB 1y23 chain A Region: 2 - 138 Aligned: 137 Modelled: 137 Confidence: 100.0% Identity: 33% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 5cs2 chain A Region: 1 - 138 Aligned: 126 Modelled: 138 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:histidine triad protein; PDBTitle: crystal structure of plasmodium falciparum diadenosine triphosphate2 hydrolase in complex with cyclomarin a Phyre2 PDB 1kpf chain A Region: 2 - 108 Aligned: 107 Modelled: 107 Confidence: 100.0% Identity: 32% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 6d6j chain B Region: 1 - 106 Aligned: 106 Modelled: 106 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: B: PDB Molecule:hit family hydrolase; PDBTitle: crystal structure of hit family hydrolase from legionella pneumophila2 philadelphia 1 Phyre2 PDB 4egu chain A Region: 1 - 113 Aligned: 113 Modelled: 113 Confidence: 100.0% Identity: 31% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:histidine triad (hit) protein; PDBTitle: 0.95a resolution structure of a histidine triad protein from2 clostridium difficile Phyre2 PDB 1rzy chain A Region: 2 - 108 Aligned: 107 Modelled: 107 Confidence: 100.0% Identity: 32% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 3n1t chain E Region: 2 - 110 Aligned: 109 Modelled: 109 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: E: PDB Molecule:hit-like protein hint; PDBTitle: crystal structure of the h101a mutant echint gmp complex Phyre2 PDB 1ems chain A domain 1 Region: 1 - 135 Aligned: 124 Modelled: 135 Confidence: 100.0% Identity: 29% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 2oik chain A domain 1 Region: 2 - 138 Aligned: 128 Modelled: 137 Confidence: 100.0% Identity: 19% Fold: HIT-like Superfamily: HIT-like Family: HIT (HINT, histidine triad) family of protein kinase-interacting proteins Phyre2 PDB 1ems chain B Region: 2 - 111 Aligned: 110 Modelled: 110 Confidence: 100.0% Identity: 31% PDB header:antitumor protein Chain: B: PDB Molecule:nit-fragile histidine triad fusion protein; PDBTitle: crystal structure of the c. elegans nitfhit protein Phyre2 PDB 3r6f chain A Region: 2 - 136 Aligned: 127 Modelled: 133 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:hit family protein; PDBTitle: crystal structure of a zinc-containing hit family protein from2 encephalitozoon cuniculi Phyre2 1 c3l7xA_ 2 c3o0mB_ 3 c2eo4A_ 4 c3p0tB_ 5 c6iq1A_ 6 c3ksvA_ 7 c3lb5B_ 8 c3anoA_ 9 c3imiB_ 10 d1y23a_ 11 c5cs2A_ 12 d1kpfa_ 13 c6d6jB_ 14 c4eguA_ 15 d1rzya_ 16 c3n1tE_ 17 d1emsa1 18 d2oika1 19 c1emsB_ 20 c3r6fA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99