1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	S	K	I	A	T	A	F	K	T	A	T	F	A	L	A	A	G	A	V	A	L	G	L	A	S	P	A	D	A	A	A	G	T	M	Y	G	D	P	A	A	A	A	K	Y	W	R	Q	Q	T	Y	D	D	C	V	L	M	S
Secondary structure
SS confidence
Disorder		?	?	?	?																								?	?	?	?																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	D	V	I	G	Q	V	T	G	R	E	P	S	E	R	A	I	I	K	V	A	Q	S	T	P	S	V	V	H	P	G	S	I	Y	T	K	P	A	D	A	E	H	P	N	S	G	M	G	T	S	V	A	D	I	P	T	L	L	A
Secondary structure
SS confidence
Disorder																											?														?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	Y	G	V	D	A	V	I	T	D	E	D	H	A	T	A	T	G	V	A	T	G	M	A	A	L	E	Q	Y	L	G	S	G	H	A	V	I	V	S	I	N	A	E	M	I	W	G	Q	P	V	E	E	T	D	S	A	G	N	P	R
Secondary structure
SS confidence
Disorder									?	?	?	?		?	?		?	?																															?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.
Sequence		S	D	H	A	V	V	V	T	G	V	D	T	E	N	G	I	V	H	L	N	D	S	G	T	P	T	G	R	D	E	Q	I	P	M	E	T	F	V	E	A	W	A	T	S	H	D	F	M	A	V	T	T
Secondary structure
SS confidence
Disorder																											?		?																							?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 40%) Beta strand ( 14%)

Rank Aligned region

PDB 3erv chain A Region: 47 - 230 Aligned: 171 Modelled: 184 Confidence: 99.7% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative c39-like peptidase; PDBTitle: crystal structure of an putative c39-like peptidase from bacillus2 anthracis Phyre2 PDB 6mpz chain A Region: 50 - 231 Aligned: 122 Modelled: 140 Confidence: 99.1% Identity: 20% PDB header:transport protein Chain: A: PDB Molecule:double glycine motif protease domain from ams/pcat PDBTitle: crystal structure of a double glycine motif protease from ams/pcat2 transporter in complex with the leader peptide Phyre2 PDB 3k8u chain A Region: 49 - 231 Aligned: 130 Modelled: 147 Confidence: 99.1% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:putative abc transporter, atp-binding protein coma; PDBTitle: crystal structure of the peptidase domain of streptococcus coma, a bi-2 functional abc transporter involved in quorum sensing pathway Phyre2 PDB 3zua chain A Region: 55 - 231 Aligned: 119 Modelled: 133 Confidence: 98.4% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:alpha-hemolysin translocation atp-binding protein hlyb; PDBTitle: a c39-like domain Phyre2 PDB 4ry2 chain A Region: 50 - 221 Aligned: 117 Modelled: 136 Confidence: 97.8% Identity: 23% PDB header:transport protein/hydrolase Chain: A: PDB Molecule:abc-type bacteriocin transporter; PDBTitle: crystal structure of the peptidase-containing abc transporter pcat1 Phyre2 PDB 2bu3 chain A domain 1 Region: 45 - 220 Aligned: 141 Modelled: 155 Confidence: 97.8% Identity: 16% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Phytochelatin synthase Phyre2 PDB 1cv8 chain A Region: 49 - 202 Aligned: 122 Modelled: 140 Confidence: 97.5% Identity: 15% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 2btw chain A Region: 45 - 220 Aligned: 141 Modelled: 145 Confidence: 97.2% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:alr0975 protein; PDBTitle: crystal structure of alr0975 Phyre2 PDB 3b79 chain A Region: 55 - 221 Aligned: 112 Modelled: 114 Confidence: 97.2% Identity: 19% PDB header:nucleotide binding protein Chain: A: PDB Molecule:toxin secretion atp-binding protein; PDBTitle: crystal structure of the n-terminal peptidase c39 like2 domain of the toxin secretion atp-binding protein from3 vibrio parahaemolyticus Phyre2 PDB 2c0y chain A Region: 50 - 209 Aligned: 145 Modelled: 145 Confidence: 96.8% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:procathepsin s; PDBTitle: the crystal structure of a cys25ala mutant of human procathepsin s Phyre2 PDB 7pck chain A Region: 49 - 209 Aligned: 143 Modelled: 143 Confidence: 96.6% Identity: 20% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 3qt4 chain A Region: 49 - 209 Aligned: 144 Modelled: 144 Confidence: 96.5% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:cathepsin-l-like midgut cysteine proteinase; PDBTitle: structure of digestive procathepsin l 3 of tenebrio molitor larval2 midgut Phyre2 PDB 3qj3 chain B Region: 49 - 200 Aligned: 134 Modelled: 134 Confidence: 96.3% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:cathepsin l-like protein; PDBTitle: structure of digestive procathepsin l2 proteinase from tenebrio2 molitor larval midgut Phyre2 PDB 2o6x chain A Region: 49 - 200 Aligned: 135 Modelled: 135 Confidence: 96.2% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:secreted cathepsin l 1; PDBTitle: crystal structure of procathepsin l1 from fasciola hepatica Phyre2 PDB 1vsn chain A domain 1 Region: 56 - 209 Aligned: 136 Modelled: 136 Confidence: 96.1% Identity: 18% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 3hhi chain B Region: 50 - 209 Aligned: 133 Modelled: 142 Confidence: 95.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:cathepsin b-like cysteine protease; PDBTitle: crystal structure of cathepsin b from t. brucei in complex with ca074 Phyre2 PDB 6hqz chain B Region: 112 - 230 Aligned: 98 Modelled: 119 Confidence: 95.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:avrrpt2; PDBTitle: crystal structure of the type iii effector protein avrrpt2 from2 erwinia amylovora, a c70 family cysteine protease Phyre2 PDB 3pbh chain A Region: 49 - 209 Aligned: 144 Modelled: 144 Confidence: 95.9% Identity: 18% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 1cs8 chain A Region: 49 - 200 Aligned: 136 Modelled: 136 Confidence: 95.6% Identity: 18% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 6czk chain A Region: 50 - 200 Aligned: 135 Modelled: 135 Confidence: 95.4% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:pro-cathepsin h; PDBTitle: crystal structure of wild-type human pro-cathepsin h Phyre2 1 c3ervA_ 2 c6mpzA_ 3 c3k8uA_ 4 c3zuaA_ 5 c4ry2A_ 6 d2bu3a1 7 d1cv8a_ 8 c2btwA_ 9 c3b79A_ 10 c2c0yA_ 11 d7pcka_ 12 c3qt4A_ 13 c3qj3B_ 14 c2o6xA_ 15 d1vsna1 16 c3hhiB_ 17 c6hqzB_ 18 d3pbha_ 19 d1cs8a_ 20 c6czkA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109