1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	Q	R	S	L	G	V	N	G	R	K	L	A	M	S	A	R	S	A	K	R	E	R	K	N	A	S	T	A	A	S	K	C	Y	V	V	P	P	S	A	R	G	W	V	H	A	Y	S	V	T	A	T	S	M	L	N	R	R	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?						?	?	?	?	?							?	?	?	?	?		?											?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	I	L	D	Y	L	Q	G	A	V	W	V	L	P	T	F	G	V	A	I	G	L	G	S	G	A	V	L	S	M	I	P	V	K	S	G	T	L	I	D	K	L	M	F	Q	G	T	P	G	D	A	R	G	V	L	I	V	V	S	A
Secondary structure
SS confidence
Disorder																																		?	?						?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	M	I	T	T	I	G	I	V	F	S	L	T	V	L	S	L	Q	I	A	S	S	Q	F	S	V	R	L	L	R	T	F	L	R	D	V	P	N	Q	V	V	L	A	I	F	A	C	T	F	A	Y	S	T	G	G	L	H	T	V	G
Secondary structure
SS confidence
Disorder																						?																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	H	R	D	G	G	A	F	I	P	K	V	A	V	T	G	S	L	A	L	A	F	V	S	I	A	A	L	I	Y	F	L	H	H	L	M	H	S	I	Q	I	D	T	I	M	D	K	V	R	L	R	T	L	G	L	V	D	Q	L	Y
Secondary structure
SS confidence
Disorder		?			?	?																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	E	S	D	T	A	D	R	Q	V	E	T	P	P	S	P	P	A	D	A	V	P	L	L	A	P	H	S	G	Y	L	Q	T	V	D	V	D	D	I	A	E	L	A	A	A	S	R	Y	T	A	L	L	V	T	F	V	G	D	Y	V
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	A	G	G	L	L	G	W	C	W	R	R	G	T	A	P	G	A	P	G	S	D	F	P	Q	R	C	L	R	H	V	H	I	G	F	E	R	T	L	Q	Q	D	I	R	F	G	L	R	Q	M	V	D	I	A	L	R	A	L	S	P
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	L	N	D	P	Y	T	A	I	Q	V	V	H	H	L	S	A	V	E	S	V	L	A	S	R	A	L	P	D	D	V	R	R	D	R	A	G	E	L	L	F	W	L	P	Y	P	S	F	A	T	Y	L	H	V	G	C	A	Q	I	R
Secondary structure
SS confidence
Disorder																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		R	Y	G	S	R	E	P	L	V	L	T	A	L	L	Q	L	L	S	A	V	A	Q	N	C	V	D	P	S	R	R	V	A	V	Q	T	Q	I	A	L	V	V	R	A	A	Q	R	E	F	A	D	E	S	D	R	A	M	V	L	G	A
Secondary structure
SS confidence
Disorder																																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.
Sequence		A	A	R	A	T	E	V	V	E	R	P	G	T	L	A	P	P	P	S	T	F	G	Q	V	A	A	A	Q	A	A	A	S	T	I	R	S	A	D	R	D	G
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?	?	?	?		?	?	?	?	?							?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 64%) Beta strand ( 6%) TM helix ( 18%) (View membrane topology prediction)

Rank Aligned region

PDB 3h5q chain A Region: 201 - 336 Aligned: 132 Modelled: 136 Confidence: 98.2% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside phosphorylase; PDBTitle: crystal structure of a putative pyrimidine-nucleoside phosphorylase2 from staphylococcus aureus Phyre2 PDB 1brw chain A domain 3 Region: 257 - 336 Aligned: 76 Modelled: 80 Confidence: 98.2% Identity: 20% Fold: alpha/beta-Hammerhead Superfamily: Pyrimidine nucleoside phosphorylase C-terminal domain Family: Pyrimidine nucleoside phosphorylase C-terminal domain Phyre2 PDB 2dsj chain A Region: 231 - 336 Aligned: 102 Modelled: 106 Confidence: 98.2% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:pyrimidine-nucleoside (thymidine) phosphorylase; PDBTitle: crystal structure of project id tt0128 from thermus thermophilus hb8 Phyre2 PDB 1brw chain B Region: 231 - 336 Aligned: 102 Modelled: 106 Confidence: 98.1% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:protein (pyrimidine nucleoside phosphorylase); PDBTitle: the crystal structure of pyrimidine nucleoside2 phosphorylase in a closed conformation Phyre2 PDB 1uou chain A domain 3 Region: 261 - 336 Aligned: 73 Modelled: 76 Confidence: 98.0% Identity: 22% Fold: alpha/beta-Hammerhead Superfamily: Pyrimidine nucleoside phosphorylase C-terminal domain Family: Pyrimidine nucleoside phosphorylase C-terminal domain Phyre2 PDB 1otp chain A Region: 201 - 337 Aligned: 134 Modelled: 134 Confidence: 98.0% Identity: 8% PDB header:phosphorylase Chain: A: PDB Molecule:thymidine phosphorylase; PDBTitle: structural and theoretical studies suggest domain movement produces an2 active conformation of thymidine phosphorylase Phyre2 PDB 2j0f chain C Region: 201 - 337 Aligned: 134 Modelled: 137 Confidence: 98.0% Identity: 16% PDB header:transferase Chain: C: PDB Molecule:thymidine phosphorylase; PDBTitle: structural basis for non-competitive product inhibition in2 human thymidine phosphorylase: implication for drug design Phyre2 PDB 2tpt chain A domain 3 Region: 261 - 336 Aligned: 73 Modelled: 76 Confidence: 97.9% Identity: 12% Fold: alpha/beta-Hammerhead Superfamily: Pyrimidine nucleoside phosphorylase C-terminal domain Family: Pyrimidine nucleoside phosphorylase C-terminal domain Phyre2 PDB 4ga5 chain H Region: 201 - 336 Aligned: 133 Modelled: 136 Confidence: 97.8% Identity: 16% PDB header:transferase Chain: H: PDB Molecule:putative thymidine phosphorylase; PDBTitle: crystal structure of amp phosphorylase c-terminal deletion mutant in2 the apo-form Phyre2 PDB 1qap chain A domain 2 Region: 220 - 312 Aligned: 93 Modelled: 93 Confidence: 93.7% Identity: 14% Fold: alpha/beta-Hammerhead Superfamily: Nicotinate/Quinolinate PRTase N-terminal domain-like Family: NadC N-terminal domain-like Phyre2 PDB 1qap chain A Region: 220 - 312 Aligned: 93 Modelled: 93 Confidence: 93.0% Identity: 14% PDB header:glycosyltransferase Chain: A: PDB Molecule:quinolinic acid phosphoribosyltransferase; PDBTitle: quinolinic acid phosphoribosyltransferase with bound2 quinolinic acid Phyre2 PDB 5nen chain A Region: 263 - 311 Aligned: 32 Modelled: 32 Confidence: 80.3% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:lipase c; PDBTitle: crystal structure of the soluble domain of lipc, a membrane fusion2 protein of a type i secretion system Phyre2 PDB 1t5e chain B Region: 257 - 311 Aligned: 37 Modelled: 37 Confidence: 79.9% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:multidrug resistance protein mexa; PDBTitle: the structure of mexa Phyre2 PDB 1o4u chain A Region: 225 - 312 Aligned: 83 Modelled: 88 Confidence: 77.3% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:type ii quinolic acid phosphoribosyltransferase; PDBTitle: crystal structure of a nicotinate nucleotide pyrophosphorylase2 (tm1645) from thermotoga maritima at 2.50 a resolution Phyre2 PDB 3paj chain A Region: 220 - 312 Aligned: 93 Modelled: 93 Confidence: 76.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase, carboxylating; PDBTitle: 2.00 angstrom resolution crystal structure of a quinolinate2 phosphoribosyltransferase from vibrio cholerae o1 biovar eltor str.3 n16961 Phyre2 PDB 1vf7 chain A Region: 257 - 311 Aligned: 37 Modelled: 37 Confidence: 75.3% Identity: 19% Fold: HlyD-like secretion proteins Superfamily: HlyD-like secretion proteins Family: HlyD-like secretion proteins Phyre2 PDB 2f1m chain A Region: 257 - 311 Aligned: 37 Modelled: 37 Confidence: 73.3% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:acriflavine resistance protein a; PDBTitle: conformational flexibility in the multidrug efflux system protein acra Phyre2 PDB 5c22 chain A Region: 259 - 311 Aligned: 36 Modelled: 36 Confidence: 73.2% Identity: 36% PDB header:protein transport Chain: A: PDB Molecule:chromosomal hemolysin d; PDBTitle: crystal structure of zn-bound hlyd from e. coli Phyre2 PDB 3lnn chain B Region: 256 - 311 Aligned: 38 Modelled: 38 Confidence: 73.1% Identity: 39% PDB header:metal transport Chain: B: PDB Molecule:membrane fusion protein (mfp) heavy metal cation efflux PDBTitle: crystal structure of zneb from cupriavidus metallidurans Phyre2 PDB 2jbm chain A Region: 231 - 312 Aligned: 80 Modelled: 82 Confidence: 72.6% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: qprtase structure from human Phyre2 1 c3h5qA_ 2 d1brwa3 3 c2dsjA_ 4 c1brwB_ 5 d1uoua3 6 c1otpA_ 7 c2j0fC_ 8 d2tpta3 9 c4ga5H_ 10 d1qapa2 11 c1qapA_ 12 c5nenA_ 13 c1t5eB_ 14 c1o4uA_ 15 c3pajA_ 16 d1vf7a_ 17 c2f1mA_ 18 c5c22A_ 19 c3lnnB_ 20 c2jbmA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110