1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	P	A	D	L	A	E	L	L	K	A	T	A	A	A	V	L	A	E	R	G	L	D	A	S	A	L	P	Q	M	V	T	V	E	R	P	R	I	P	E	H	G	D	Y	A	S	N	L	A	M	Q	L	A	K	K	V	G	T	N
Secondary structure
SS confidence
Disorder		?	?																																																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	R	E	L	A	G	W	L	A	E	A	L	T	K	V	D	G	I	A	S	A	E	V	A	G	P	G	F	I	N	M	R	L	E	T	A	A	Q	A	K	V	V	T	S	V	I	D	A	G	H	S	Y	G	H	S	L	L	L	A	G
Secondary structure
SS confidence
Disorder																											?																									?	?	?		?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	K	V	N	L	E	F	V	S	A	N	P	T	G	P	I	H	I	G	G	T	R	W	A	A	V	G	D	A	L	G	R	L	L	T	T	Q	G	A	D	V	V	R	E	Y	Y	F	N	D	H	G	A	Q	I	D	R	F	A	N	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	I	A	A	A	K	G	E	P	T	P	Q	D	G	Y	A	G	S	Y	I	T	N	I	A	E	Q	V	L	Q	K	A	P	D	A	L	S	L	P	D	A	E	L	R	E	T	F	R	A	I	G	V	D	L	M	F	D	H	I	K	Q
Secondary structure
SS confidence
Disorder							?			?	?																						?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	L	H	E	F	G	T	D	F	D	V	Y	T	H	E	D	S	M	H	T	G	G	R	V	E	N	A	I	A	R	L	R	E	T	G	N	I	Y	E	K	D	G	A	T	W	L	R	T	S	A	F	G	D	D	K	D	R	V	V	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	S	D	G	K	P	A	Y	I	A	G	D	L	A	Y	Y	L	D	K	R	Q	R	G	F	D	L	C	I	Y	M	L	G	A	D	H	H	G	Y	I	A	R	L	K	A	A	A	A	A	F	G	D	D	P	A	T	V	E	V	L	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	Q	M	V	N	L	V	R	D	G	Q	P	V	R	M	S	K	R	A	G	T	V	L	T	L	D	D	L	V	E	A	I	G	V	D	A	A	R	Y	S	L	I	R	S	S	V	D	T	A	I	D	I	D	L	A	L	W	S	S	A
Secondary structure
SS confidence
Disorder												?		?		?	?																																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		S	N	E	N	P	V	Y	Y	V	Q	Y	A	H	A	R	L	S	A	L	A	R	N	A	A	E	L	A	L	I	P	D	T	N	H	L	E	L	L	N	H	D	K	E	G	T	L	L	R	T	L	G	E	F	P	R	V	L	E	T	A
Secondary structure
SS confidence
Disorder		?	?																						?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	S	L	R	E	P	H	R	V	C	R	Y	L	E	D	L	A	G	D	Y	H	R	F	Y	D	S	C	R	V	L	P	Q	G	D	E	Q	P	T	D	L	H	T	A	R	L	A	L	C	Q	A	T	R	Q	V	I	A	N	G	L	A
Secondary structure
SS confidence
Disorder																																				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550
Sequence		I	I	G	V	T	A	P	E	R	M
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 53%) Beta strand ( 13%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 4r3z chain B Region: 6 - 550 Aligned: 530 Modelled: 545 Confidence: 100.0% Identity: 24% PDB header:protein binding/ligase Chain: B: PDB Molecule:arginine--trna ligase, cytoplasmic; PDBTitle: crystal structure of human argrs-glnrs-aimp1 complex Phyre2 PDB 1f7u chain A Region: 5 - 550 Aligned: 527 Modelled: 539 Confidence: 100.0% Identity: 28% PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of the arginyl-trna synthetase complexed with the2 trna(arg) and l-arg Phyre2 PDB 2zuf chain A Region: 5 - 550 Aligned: 529 Modelled: 537 Confidence: 100.0% Identity: 28% PDB header:ligase/rna Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of pyrococcus horikoshii arginyl-trna2 synthetase complexed with trna(arg) Phyre2 PDB 5jld chain A Region: 1 - 550 Aligned: 530 Modelled: 548 Confidence: 100.0% Identity: 16% PDB header:ligase Chain: A: PDB Molecule:arginyl-trna synthetase, putative; PDBTitle: crystal structure of arginyl-trna synthetase from plasmodium2 falciparum (pfrrs) Phyre2 PDB 6ao8 chain A Region: 5 - 550 Aligned: 527 Modelled: 546 Confidence: 100.0% Identity: 27% PDB header:ligase Chain: A: PDB Molecule:arginine--trna ligase; PDBTitle: crystal structure of arginyl-trna_synthetase from neisseria2 gonorrhoeae in complex with arginine Phyre2 PDB 4oby chain A Region: 5 - 549 Aligned: 531 Modelled: 545 Confidence: 100.0% Identity: 26% PDB header:ligase Chain: A: PDB Molecule:arginine--trna ligase; PDBTitle: crystal structure of e.coli arginyl-trna synthetase and ligand binding2 studies revealed key residues in arginine recognition Phyre2 PDB 4q2t chain B Region: 5 - 550 Aligned: 535 Modelled: 546 Confidence: 100.0% Identity: 23% PDB header:ligase Chain: B: PDB Molecule:arginine--trna ligase, cytoplasmic; PDBTitle: crystal structure of arginyl-trna synthetase complexed with l-arginine Phyre2 PDB 1iq0 chain A Region: 6 - 550 Aligned: 524 Modelled: 545 Confidence: 100.0% Identity: 26% PDB header:ligase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: thermus thermophilus arginyl-trna synthetase Phyre2 PDB 3fnr chain A Region: 93 - 550 Aligned: 443 Modelled: 458 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:arginyl-trna synthetase; PDBTitle: crystal structure of putative arginyl t-rna synthetase from2 campylobacter jejuni; Phyre2 PDB 1f7u chain A domain 2 Region: 114 - 422 Aligned: 300 Modelled: 309 Confidence: 100.0% Identity: 23% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 1iq0 chain A domain 2 Region: 115 - 421 Aligned: 307 Modelled: 307 Confidence: 100.0% Identity: 21% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Nucleotidylyl transferase Family: Class I aminoacyl-tRNA synthetases (RS), catalytic domain Phyre2 PDB 2x1l chain C Region: 120 - 542 Aligned: 371 Modelled: 376 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: C: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of mycobacterium smegmatis methionyl-trna synthetase2 in complex with methionine and adenosine Phyre2 PDB 2ct8 chain A Region: 121 - 539 Aligned: 362 Modelled: 378 Confidence: 100.0% Identity: 17% PDB header:ligase/rna Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of aquifex aeolicus methionyl-trna2 synthetase complexed with trna(met) and methionyl-adenylate3 anologue Phyre2 PDB 4qrd chain A Region: 119 - 542 Aligned: 371 Modelled: 383 Confidence: 100.0% Identity: 20% PDB header:ligase/ligase inhibitor Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: structure of methionyl-trna synthetase in complex with n-(1h-2 benzimidazol-2-ylmethyl)-n'-(2,4-dichlorophenyl)-6-(morpholin-4-yl)-3 1,3,5-triazine-2,4-diamine Phyre2 PDB 3tqo chain A Region: 119 - 546 Aligned: 361 Modelled: 402 Confidence: 100.0% Identity: 16% PDB header:ligase Chain: A: PDB Molecule:cysteinyl-trna synthetase; PDBTitle: structure of the cysteinyl-trna synthetase (cyss) from coxiella2 burnetii. Phyre2 PDB 1woy chain A Region: 120 - 546 Aligned: 371 Modelled: 386 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: crystal structure of methionyl trna synthetase y225f mutant2 from thermus thermophilus Phyre2 PDB 1pfu chain A Region: 121 - 542 Aligned: 364 Modelled: 381 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: methionyl-trna synthetase from escherichia coli complexed2 with methionine phosphinate Phyre2 PDB 3tun chain A Region: 120 - 549 Aligned: 376 Modelled: 389 Confidence: 100.0% Identity: 18% PDB header:ligase/ligase inhibitor Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: trypanosoma brucei methionyl-trna synthetase in complex with inhibitor2 chem 1356 Phyre2 PDB 3kfl chain A Region: 119 - 549 Aligned: 378 Modelled: 390 Confidence: 100.0% Identity: 19% PDB header:ligase Chain: A: PDB Molecule:methionyl-trna synthetase; PDBTitle: leishmania major methionyl-trna synthetase in complex with2 methionyladenylate and pyrophosphate Phyre2 PDB 5urb chain B Region: 121 - 548 Aligned: 372 Modelled: 387 Confidence: 100.0% Identity: 20% PDB header:ligase Chain: B: PDB Molecule:methionine--trna ligase; PDBTitle: crystal structure of methionyl-trna synthetase (metrs) from2 acinetobacter baumannii with bound l-methionine Phyre2 1 c4r3zB_ 2 c1f7uA_ 3 c2zufA_ 4 c5jldA_ 5 c6ao8A_ 6 c4obyA_ 7 c4q2tB_ 8 c1iq0A_ 9 c3fnrA_ 10 d1f7ua2 11 d1iq0a2 12 c2x1lC_ 13 c2ct8A_ 14 c4qrdA_ 15 c3tqoA_ 16 c1woyA_ 17 c1pfuA_ 18 c3tunA_ 19 c3kflA_ 20 c5urbB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227