1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	T	Q	A	L	L	P	S	G	L	V	A	S	A	V	V	A	A	S	S	A	N	L	G	P	G	F	D	S	V	G	L	A	L	S	L	Y	D	E	I	I	V	E	T	T	D	S	G	L	T	V	T	V	D	G	E	G	G	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?								?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	V	P	L	G	P	E	H	L	V	V	R	A	V	Q	H	G	L	Q	A	A	G	V	S	A	A	G	L	A	V	R	C	R	N	A	I	P	H	S	R	G	L	G	S	S	A	A	A	V	V	G	G	L	A	A	V	N	G	L	V
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	Q	T	D	S	S	P	S	S	D	A	E	L	I	Q	L	A	S	E	F	E	G	H	P	D	N	A	A	A	A	V	L	G	G	A	V	V	S	W	T	D	H	S	G	D	R	P	N	Y	S	A	V	S	L	R	L	H	P	D	I
Secondary structure
SS confidence
Disorder						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	L	F	T	A	I	P	E	Q	R	S	S	T	A	E	T	R	V	L	L	P	A	Q	V	S	H	D	D	A	R	F	N	V	S	R	A	A	L	L	V	V	A	L	T	E	R	P	D	L	L	M	A	A	T	E	D	L	L	H	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	Q	R	A	A	A	M	T	A	S	A	E	Y	L	R	L	L	R	R	H	N	V	A	A	A	L	S	G	A	G	P	S	L	I	A	L	S	T	D	S	E	L	P	T	D	A	V	E	F	G	A	A	K	G	F	A	V	T	E	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.
Sequence		T	V	G	E	A	V	R	W	S	P	T	V	R	V	P	G
Secondary structure
SS confidence
Disorder											?			?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 35%) Beta strand ( 26%)

Rank Aligned region

PDB 6cyz chain A Region: 7 - 308 Aligned: 291 Modelled: 302 Confidence: 100.0% Identity: 60% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: mycobacterial homoserine kinase thrb in complex with amppnp Phyre2 PDB 5wat chain B Region: 7 - 309 Aligned: 296 Modelled: 299 Confidence: 100.0% Identity: 51% PDB header:transferase Chain: B: PDB Molecule:homoserine kinase; PDBTitle: corynebacterium glutamicum full length homoserine kinase Phyre2 PDB 4p52 chain A Region: 9 - 308 Aligned: 290 Modelled: 299 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: crystal structure of homoserine kinase from cytophaga hutchinsonii2 atcc 33406, nysgrc target 032717. Phyre2 PDB 4rpf chain A Region: 13 - 308 Aligned: 285 Modelled: 296 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: crystal structure of homoserine kinase from yersinia pestis nepal516,2 nysgrc target 032715 Phyre2 PDB 1fwl chain D Region: 11 - 308 Aligned: 286 Modelled: 294 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: D: PDB Molecule:homoserine kinase; PDBTitle: crystal structure of homoserine kinase Phyre2 PDB 3pyg chain A Region: 12 - 308 Aligned: 280 Modelled: 297 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:4-diphosphocytidyl-2-c-methyl-d-erythritol kinase; PDBTitle: mycobacterium tuberculosis 4-diphosphocytidyl-2-c-methyl-d-erythritol2 kinase (ispe) in complex with adp Phyre2 PDB 3hul chain A Region: 12 - 308 Aligned: 268 Modelled: 297 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:homoserine kinase; PDBTitle: structure of putative homoserine kinase thrb from listeria2 monocytogenes Phyre2 PDB 2v34 chain B Region: 13 - 302 Aligned: 256 Modelled: 290 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:4-diphosphocytidyl-2c-methyl-d-erythritol kinase; PDBTitle: ispe in complex with cytidine and ligand Phyre2 PDB 1uek chain A Region: 13 - 305 Aligned: 256 Modelled: 288 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:4-(cytidine 5'-diphospho)-2c-methyl-d-erythritol PDBTitle: crystal structure of 4-(cytidine 5'-diphospho)-2c-methyl-d-2 erythritol kinase Phyre2 PDB 1oj4 chain B Region: 14 - 302 Aligned: 254 Modelled: 273 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:4-diphosphocytidyl-2-c-methyl-d-erythritol PDBTitle: ternary complex of2 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase Phyre2 PDB 4z7c chain A Region: 11 - 312 Aligned: 289 Modelled: 302 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:diphosphomevalonate decarboxylase; PDBTitle: diphosphomevalonate decarboxylase from the sulfolobus solfataricus,2 space group h32 Phyre2 PDB 2cz9 chain A Region: 13 - 308 Aligned: 286 Modelled: 292 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:probable galactokinase; PDBTitle: crystal structure of galactokinase from pyrococcus horikoshi Phyre2 PDB 2hk3 chain A Region: 12 - 308 Aligned: 288 Modelled: 292 Confidence: 100.0% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:diphosphomevalonate decarboxylase; PDBTitle: crystal structure of mevalonate diphosphate decarboxylase2 from staphylococcus aureus (orthorhombic form) Phyre2 PDB 6n0y chain B Region: 12 - 308 Aligned: 287 Modelled: 294 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:diphosphomevalonate decarboxylase; PDBTitle: crystal structure of anaerolinea thermophila mevalonate 5-phosphate2 decarboxylase complexed with (r)-mvapp Phyre2 PDB 5v2l chain A Region: 11 - 311 Aligned: 290 Modelled: 297 Confidence: 100.0% Identity: 19% PDB header:lyase Chain: A: PDB Molecule:mevalonate diphosphate decarboxylase; PDBTitle: mevalonate diphosphate mediated atp binding mechanism of the2 mevalonate diphosphate decarboxylase from enterococcus faecalis Phyre2 PDB 2gs8 chain A Region: 10 - 308 Aligned: 281 Modelled: 293 Confidence: 100.0% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:mevalonate pyrophosphate decarboxylase; PDBTitle: structure of mevalonate pyrophosphate decarboxylase from streptococcus2 pyogenes Phyre2 PDB 4hac chain A Region: 13 - 309 Aligned: 277 Modelled: 293 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:mevalonate kinase; PDBTitle: crystal structure of the mevalonate kinase from an archaeon2 methanosarcina mazei Phyre2 PDB 2x7i chain A Region: 11 - 303 Aligned: 276 Modelled: 291 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:mevalonate kinase; PDBTitle: crystal structure of mevalonate kinase from methicillin-2 resistant staphylococcus aureus mrsa252 Phyre2 PDB 2hfu chain B Region: 8 - 303 Aligned: 287 Modelled: 292 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:mevalonate kinase, putative; PDBTitle: crystal structure of l. major mevalonate kinase in complex2 with r-mevalonate Phyre2 PDB 3k17 chain A Region: 12 - 304 Aligned: 289 Modelled: 293 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:lin0012 protein; PDBTitle: crystal structure of a lin0012 protein from listeria innocua Phyre2 1 c6cyzA_ 2 c5watB_ 3 c4p52A_ 4 c4rpfA_ 5 c1fwlD_ 6 c3pygA_ 7 c3hulA_ 8 c2v34B_ 9 c1uekA_ 10 c1oj4B_ 11 c4z7cA_ 12 c2cz9A_ 13 c2hk3A_ 14 c6n0yB_ 15 c5v2lA_ 16 c2gs8A_ 17 c4hacA_ 18 c2x7iA_ 19 c2hfuB_ 20 c3k17A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99