1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Q	Y	G	L	E	V	S	S	D	V	A	G	V	A	G	G	L	L	A	L	S	Y	R	G	A	G	V	P	L	R	E	L	A	L	V	G	L	T	A	A	I	I	T	Y	F	A	T	G	P	V	R	M	L	A	S	R	L	G	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?								?	?				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	Y	P	R	E	R	D	V	H	V	T	P	T	P	R	M	G	G	L	A	M	F	L	G	I	V	G	A	V	F	L	A	S	Q	L	P	A	L	T	R	G	F	V	Y	S	T	G	M	P	A	V	L	V	A	G	A	V	I	M
Secondary structure
SS confidence
Disorder							?		?	?	?	?			?																							?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	I	G	L	I	D	D	R	W	G	L	D	A	L	T	K	F	A	G	Q	I	T	A	A	S	V	L	V	T	M	G	V	A	W	S	V	L	Y	I	P	V	G	G	V	G	T	I	V	L	D	Q	A	S	S	I	L	L	T	L	A
Secondary structure
SS confidence
Disorder																																					?							?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	T	V	S	I	V	N	A	M	N	F	V	D	G	L	D	G	L	A	A	G	L	G	L	I	T	A	L	A	I	C	M	F	S	V	G	L	L	R	D	H	G	G	D	V	L	Y	Y	P	P	A	V	I	S	V	V	L	A	G	A
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		C	L	G	F	L	P	H	N	F	H	R	A	K	I	F	M	G	D	S	G	S	M	L	I	G	L	M	L	A	A	A	S	T	T	A	A	G	P	I	S	Q	N	A	Y	G	A	R	D	V	F	A	L	L	S	P	F	L	L	V	V
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	V	M	F	V	P	M	L	D	L	L	L	A	I	V	R	R	T	R	A	G	R	S	A	F	S	P	D	K	M	H	L	H	H	R	L	L	Q	I	G	H	S	H	R	R	V	V	L	I	I	Y	L	W	V	G	I	V	A	F	G
Secondary structure
SS confidence
Disorder																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.
Sequence		A	A	S	S	I	F	F	N	P	R	D	T	A	A	V	M	L	G	A	I	V	V	A	G	V	A	T	L	I	P	L	L	R	R	G	D	D	Y	Y	D	P	D	L	D
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 55%) (View membrane topology prediction)

Rank Aligned region

PDB 4j72 chain A Region: 38 - 366 Aligned: 303 Modelled: 315 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: crystal structure of polyprenyl-phosphate n-acetyl hexosamine 1-2 phosphate transferase Phyre2 PDB 5jnq chain A Region: 30 - 362 Aligned: 287 Modelled: 319 Confidence: 100.0% Identity: 23% PDB header:transferase/antibiotic Chain: A: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: mray tunicamycin complex Phyre2 PDB 4j72 chain B Region: 30 - 366 Aligned: 280 Modelled: 288 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: crystal structure of polyprenyl-phosphate n-acetyl hexosamine 1-2 phosphate transferase Phyre2 PDB 5lev chain A Region: 28 - 364 Aligned: 311 Modelled: 319 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:udp-n-acetylglucosamine--dolichyl-phosphate n- PDBTitle: crystal structure of human udp-n-acetylglucosamine-dolichyl-phosphate2 n-acetylglucosaminephosphotransferase (dpagt1) (v264g mutant) Phyre2 PDB 6m97 chain A Region: 198 - 252 Aligned: 43 Modelled: 55 Confidence: 45.5% Identity: 21% PDB header:transport protein Chain: A: PDB Molecule:chimera protein of high affinity copper uptake protein 1 PDBTitle: crystal structure of the high-affinity copper transporter ctr1 Phyre2 PDB 4q0p chain A Region: 316 - 333 Aligned: 18 Modelled: 18 Confidence: 24.7% Identity: 44% PDB header:isomerase Chain: A: PDB Molecule:l-ribose isomerase; PDBTitle: crystal structure of acinetobacter sp. dl28 l-ribose isomerase in2 complex with l-ribose Phyre2 PDB 5gas chain N Region: 8 - 202 Aligned: 174 Modelled: 195 Confidence: 21.0% Identity: 17% PDB header:hydrolase Chain: N: PDB Molecule:archaeal/vacuolar-type h+-atpase subunit i; PDBTitle: thermus thermophilus v/a-atpase, conformation 2 Phyre2 PDB 2q7r chain A domain 1 Region: 37 - 79 Aligned: 38 Modelled: 43 Confidence: 20.0% Identity: 16% Fold: MAPEG domain-like Superfamily: MAPEG domain-like Family: MAPEG domain Phyre2 PDB 5un8 chain B Region: 244 - 258 Aligned: 15 Modelled: 15 Confidence: 17.7% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:protein o-glcnacase; PDBTitle: crystal structure of human o-glcnacase in complex with glycopeptide2 p53 Phyre2 PDB 2cbi chain A domain 2 Region: 244 - 258 Aligned: 15 Modelled: 15 Confidence: 17.5% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: alpha-D-glucuronidase/Hyaluronidase catalytic domain Phyre2 PDB 2cho chain A domain 2 Region: 244 - 258 Aligned: 15 Modelled: 15 Confidence: 16.1% Identity: 27% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: alpha-D-glucuronidase/Hyaluronidase catalytic domain Phyre2 PDB 2cbj chain A Region: 244 - 258 Aligned: 15 Modelled: 15 Confidence: 14.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:hyaluronidase; PDBTitle: structure of the clostridium perfringens nagj family 84 glycoside2 hydrolase, a homologue of human o-glcnacase in complex with pugnac Phyre2 PDB 2cho chain A Region: 244 - 258 Aligned: 15 Modelled: 15 Confidence: 14.3% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:glucosaminidase; PDBTitle: bacteroides thetaiotaomicron hexosaminidase with o-2 glcnacase activity Phyre2 PDB 2uui chain A Region: 37 - 79 Aligned: 38 Modelled: 43 Confidence: 14.2% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2cpw chain A domain 1 Region: 317 - 351 Aligned: 34 Modelled: 35 Confidence: 13.2% Identity: 24% Fold: RuvA C-terminal domain-like Superfamily: UBA-like Family: UBA domain Phyre2 PDB 2xsb chain A Region: 244 - 258 Aligned: 15 Modelled: 15 Confidence: 12.3% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: ogoga pugnac complex Phyre2 PDB 2pno chain I Region: 38 - 79 Aligned: 37 Modelled: 42 Confidence: 12.2% Identity: 14% PDB header:lyase Chain: I: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain J Region: 38 - 79 Aligned: 37 Modelled: 42 Confidence: 12.2% Identity: 14% PDB header:lyase Chain: J: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain E Region: 38 - 79 Aligned: 37 Modelled: 42 Confidence: 12.2% Identity: 14% PDB header:lyase Chain: E: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 PDB 2pno chain L Region: 38 - 79 Aligned: 37 Modelled: 42 Confidence: 12.2% Identity: 14% PDB header:lyase Chain: L: PDB Molecule:leukotriene c4 synthase; PDBTitle: crystal structure of human leukotriene c4 synthase Phyre2 1 c4j72A_ 2 c5jnqA_ 3 c4j72B_ 4 c5levA_ 5 c6m97A_ 6 c4q0pA_ 7 c5gasN_ 8 d2q7ra1 9 c5un8B_ 10 d2cbia2 11 d2choa2 12 c2cbjA_ 13 c2choA_ 14 c2uuiA_ 15 d2cpwa1 16 c2xsbA_ 17 c2pnoI_ 18 c2pnoJ_ 19 c2pnoE_ 20 c2pnoL_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60