1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	T	P	A	Q	D	A	P	L	V	F	P	S	V	A	F	R	P	V	R	L	F	F	I	N	V	G	L	A	A	V	A	M	L	V	A	G	V	F	G	H	L	T	V	G	M	F	L	G	L	G	L	L	L	G	L	L	N	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	V	R	R	S	A	E	S	I	T	A	K	E	H	P	L	K	R	S	M	A	L	N	S	A	S	R	L	A	I	I	T	I	L	G	L	I	I	A	Y	I	F	R	P	A	G	L	G	V	V	F	G	L	A	F	F	Q	V	L
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.
Sequence		L	V	A	T	T	A	L	P	V	L	K	K	L	R	T	A	T	E	E	P	V	A	T	Y	S	S	N	G	Q	T	G	G	S	E	G	R	S	A	S	D	D
Secondary structure
SS confidence
Disorder																?			?			?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 79%) Beta strand ( 1%) TM helix ( 50%) (View membrane topology prediction)

Rank Aligned region

PDB 3ug9 chain A Region: 10 - 111 Aligned: 101 Modelled: 102 Confidence: 62.7% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:archaeal-type opsin 1, archaeal-type opsin 2; PDBTitle: crystal structure of the closed state of channelrhodopsin Phyre2 PDB 4ezd chain B Region: 21 - 72 Aligned: 52 Modelled: 52 Confidence: 61.9% Identity: 21% PDB header:transport protein Chain: B: PDB Molecule:urea transporter 1; PDBTitle: crystal structure of the ut-b urea transporter from bos taurus bound2 to selenourea Phyre2 PDB 5zih chain A Region: 24 - 111 Aligned: 87 Modelled: 88 Confidence: 57.7% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:sensory opsin a,chrimson; PDBTitle: crystal structure of the red light-activated channelrhodopsin2 chrimson. Phyre2 PDB 3k3g chain A Region: 21 - 72 Aligned: 52 Modelled: 52 Confidence: 57.3% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:urea transporter; PDBTitle: crystal structure of the urea transporter from desulfovibrio vulgaris2 bound to 1,3-dimethylurea Phyre2 PDB 6eyu chain A Region: 18 - 111 Aligned: 94 Modelled: 94 Confidence: 20.1% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:bacteriorhodopsin; PDBTitle: crystal structure of the inward h(+) pump xenorhodopsin Phyre2 PDB 1fp1 chain D domain 1 Region: 79 - 96 Aligned: 18 Modelled: 18 Confidence: 17.6% Identity: 28% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Plant O-methyltransferase, N-terminal domain Phyre2 PDB 6csm chain C Region: 13 - 111 Aligned: 99 Modelled: 99 Confidence: 16.9% Identity: 10% PDB header:membrane protein Chain: C: PDB Molecule:gtacr1; PDBTitle: crystal structure of the natural light-gated anion channel gtacr1 Phyre2 PDB 5tr1 chain A Region: 27 - 69 Aligned: 43 Modelled: 43 Confidence: 16.2% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:chloride channel protein; PDBTitle: cryo-electron microscopy structure of a bovine clc-k chloride channel,2 alternate (class 2) conformation Phyre2 PDB 4mt1 chain A Region: 27 - 130 Aligned: 102 Modelled: 104 Confidence: 15.0% Identity: 22% PDB header:membrane protein, tranport protein Chain: A: PDB Molecule:drug efflux protein; PDBTitle: crystal structure of the neisseria gonorrhoeae mtrd inner membrane2 multidrug efflux pump Phyre2 PDB 2l35 chain A Region: 104 - 139 Aligned: 36 Modelled: 36 Confidence: 11.5% Identity: 28% PDB header:protein binding Chain: A: PDB Molecule:dap12-nkg2c_tm; PDBTitle: structure of the dap12-nkg2c transmembrane heterotrimer Phyre2 PDB 5iws chain A Region: 10 - 41 Aligned: 32 Modelled: 32 Confidence: 11.3% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:protein-n(pi)-phosphohistidine-sugar phosphotransferase PDBTitle: crystal structure of the transporter malt, the eiic domain from the2 maltose-specific phosphotransferase system Phyre2 PDB 5vaq chain C Region: 151 - 159 Aligned: 9 Modelled: 9 Confidence: 10.8% Identity: 78% PDB header:signaling protein Chain: C: PDB Molecule:fibroblast growth factor 21; PDBTitle: crystal structure of beta-klotho in complex with fgf21ct Phyre2 PDB 1o7d chain D Region: 100 - 107 Aligned: 8 Modelled: 8 Confidence: 10.3% Identity: 75% PDB header:hydrolase Chain: D: PDB Molecule:lysosomal alpha-mannosidase; PDBTitle: the structure of the bovine lysosomal a-mannosidase suggests a novel2 mechanism for low ph activation Phyre2 PDB 6qvc chain B Region: 26 - 51 Aligned: 26 Modelled: 26 Confidence: 9.0% Identity: 19% PDB header:membrane protein Chain: B: PDB Molecule:chloride channel protein 1; PDBTitle: cryoem structure of the human clc-1 chloride channel, cbs state 1 Phyre2 PDB 3org chain B Region: 16 - 51 Aligned: 36 Modelled: 36 Confidence: 8.9% Identity: 22% PDB header:transport protein Chain: B: PDB Molecule:cmclc; PDBTitle: crystal structure of a eukaryotic clc transporter Phyre2 PDB 6o7u chain A Region: 85 - 134 Aligned: 50 Modelled: 50 Confidence: 8.7% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule: PDBTitle: saccharomyces cerevisiae v-atpase stv1-vo Phyre2 PDB 1kyz chain A domain 1 Region: 79 - 96 Aligned: 18 Modelled: 18 Confidence: 8.1% Identity: 33% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Plant O-methyltransferase, N-terminal domain Phyre2 PDB 4jsp chain A Region: 10 - 44 Aligned: 35 Modelled: 35 Confidence: 8.1% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:serine/threonine-protein kinase mtor; PDBTitle: structure of mtordeltan-mlst8-atpgammas-mg complex Phyre2 PDB 2n90 chain B Region: 35 - 57 Aligned: 23 Modelled: 23 Confidence: 6.5% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:high affinity nerve growth factor receptor; PDBTitle: trka transmembrane domain nmr structure in dpc micelles Phyre2 PDB 2n90 chain A Region: 35 - 57 Aligned: 23 Modelled: 23 Confidence: 6.5% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:high affinity nerve growth factor receptor; PDBTitle: trka transmembrane domain nmr structure in dpc micelles Phyre2 1 c3ug9A_ 2 c4ezdB_ 3 c5zihA_ 4 c3k3gA_ 5 c6eyuA_ 6 d1fp1d1 7 c6csmC_ 8 c5tr1A_ 9 c4mt1A_ 10 c2l35A_ 11 c5iwsA_ 12 c5vaqC_ 13 c1o7dD_ 14 c6qvcB_ 15 c3orgB_ 16 c6o7ua_ 17 d1kyza1 18 c4jspA_ 19 c2n90B_ 20 c2n90A_ 21 22 23 24 25 26 27 28 29 30 31 32