1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	A	T	L	R	E	L	R	G	R	I	R	S	A	G	S	I	K	K	I	T	K	A	Q	E	L	I	A	T	S	R	I	A	R	A	Q	A	R	L	E	S	A	R	P	Y	A	F	E	I	T	R	M	L	T	T	L	A	A	E
Secondary structure
SS confidence
Disorder		?	?	?	?																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	L	D	H	P	L	L	V	E	R	P	E	P	K	R	A	G	V	L	V	V	S	S	D	R	G	L	C	G	A	Y	N	A	N	I	F	R	R	S	E	E	L	F	S	L	L	R	E	A	G	K	Q	P	V	L	Y	V	V	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?			?	?	?	?	?	?																																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	K	A	Q	N	Y	Y	S	F	R	N	W	N	I	T	E	S	W	M	G	F	S	E	Q	P	T	Y	E	N	A	A	E	I	A	S	T	L	V	D	A	F	L	L	G	T	D	N	G	E	D	Q	R	S	D	S	G	E	G	V	D
Secondary structure
SS confidence
Disorder																																														?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	L	H	I	V	Y	T	E	F	K	S	M	L	S	Q	S	A	E	A	H	R	I	A	P	M	V	V	E	Y	V	E	E	D	I	G	P	R	T	L	Y	S	F	E	P	D	A	T	M	L	F	E	S	L	L	P	R	Y	L	T	T
Secondary structure
SS confidence
Disorder																												?			?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	V	Y	A	A	L	L	E	S	A	A	S	E	L	A	S	R	Q	R	A	M	K	S	A	T	D	N	A	D	D	L	I	K	A	L	T	L	M	A	N	R	E	R	Q	A	Q	I	T	Q	E	I	S	E	I	V	G	G	A	N	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.
Sequence		L	A	E	A	R
Secondary structure
SS confidence
Disorder			?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 63%) Beta strand ( 10%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 6fki chain G Region: 4 - 300 Aligned: 284 Modelled: 297 Confidence: 100.0% Identity: 36% PDB header:membrane protein Chain: G: PDB Molecule:atp synthase subunit c, chloroplastic; PDBTitle: chloroplast f1fo conformation 3 Phyre2 PDB 3oaa chain O Region: 3 - 299 Aligned: 284 Modelled: 297 Confidence: 100.0% Identity: 35% PDB header:hydrolase/transport protein Chain: O: PDB Molecule:atp synthase gamma chain; PDBTitle: structure of the e.coli f1-atp synthase inhibited by subunit epsilon Phyre2 PDB 6q45 chain G Region: 2 - 301 Aligned: 280 Modelled: 300 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase gamma chain; PDBTitle: f1-atpase from fusobacterium nucleatum Phyre2 PDB 5dn6 chain G Region: 4 - 301 Aligned: 260 Modelled: 268 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase gamma chain; PDBTitle: atp synthase from paracoccus denitrificans Phyre2 PDB 6re1 chain S Region: 4 - 301 Aligned: 271 Modelled: 273 Confidence: 100.0% Identity: 27% PDB header:proton transport Chain: S: PDB Molecule:atp synthase gamma chain, mitochondrial; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 2a,2 focussed refinement of f1 head and rotor Phyre2 PDB 2w6h chain G Region: 3 - 301 Aligned: 261 Modelled: 270 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase subunit gamma, mitochondrial; PDBTitle: low resolution structures of bovine mitochondrial f1-atpase during2 controlled dehydration: hydration state 4a. Phyre2 PDB 5lqx chain G Region: 3 - 300 Aligned: 265 Modelled: 279 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase gamma subunit; PDBTitle: structure of f-atpase from pichia angusta, state3 Phyre2 PDB 6f5d chain G Region: 3 - 302 Aligned: 266 Modelled: 273 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase gamma subunit; PDBTitle: trypanosoma brucei f1-atpase Phyre2 PDB 2xok chain G Region: 3 - 300 Aligned: 263 Modelled: 268 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase subunit gamma, mitochondrial; PDBTitle: refined structure of yeast f1c10 atpase complex to 3 a resolution Phyre2 PDB 4xd7 chain G Region: 3 - 301 Aligned: 253 Modelled: 280 Confidence: 100.0% Identity: 41% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase gamma chain; PDBTitle: structure of thermophilic f1-atpase inhibited by epsilon subunit Phyre2 PDB 5zwl chain G Region: 25 - 264 Aligned: 227 Modelled: 227 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase gamma chain; PDBTitle: crystal structure of the gamma - epsilon complex of photosynthetic2 cyanobacterial f1-atpase Phyre2 PDB 6foc chain G Region: 4 - 301 Aligned: 192 Modelled: 211 Confidence: 100.0% Identity: 88% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase gamma chain; PDBTitle: f1-atpase from mycobacterium smegmatis Phyre2 PDB 2jdi chain G domain 1 Region: 3 - 301 Aligned: 183 Modelled: 190 Confidence: 100.0% Identity: 43% Fold: Pyruvate kinase C-terminal domain-like Superfamily: ATP synthase (F1-ATPase), gamma subunit Family: ATP synthase (F1-ATPase), gamma subunit Phyre2 PDB 1fs0 chain G Region: 20 - 262 Aligned: 219 Modelled: 243 Confidence: 100.0% Identity: 33% Fold: Pyruvate kinase C-terminal domain-like Superfamily: ATP synthase (F1-ATPase), gamma subunit Family: ATP synthase (F1-ATPase), gamma subunit Phyre2 PDB 2qe7 chain G Region: 5 - 282 Aligned: 226 Modelled: 235 Confidence: 100.0% Identity: 39% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase subunit gamma; PDBTitle: crystal structure of the f1-atpase from the thermoalkaliphilic2 bacterium bacillus sp. ta2.a1 Phyre2 PDB 2w6j chain G Region: 3 - 298 Aligned: 180 Modelled: 188 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: G: PDB Molecule:atp synthase subunit gamma, mitochondrial; PDBTitle: low resolution structures of bovine mitochondrial f1-atpase during2 controlled dehydration: hydration state 5. Phyre2 PDB 3fks chain Y Region: 3 - 300 Aligned: 187 Modelled: 192 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: Y: PDB Molecule:atp synthase subunit gamma, mitochondrial; PDBTitle: yeast f1 atpase in the absence of bound nucleotides Phyre2 PDB 1mab chain G Region: 6 - 302 Aligned: 124 Modelled: 124 Confidence: 100.0% Identity: 44% Fold: Pyruvate kinase C-terminal domain-like Superfamily: ATP synthase (F1-ATPase), gamma subunit Family: ATP synthase (F1-ATPase), gamma subunit Phyre2 PDB 3re1 chain B Region: 79 - 135 Aligned: 48 Modelled: 57 Confidence: 68.0% Identity: 19% PDB header:lyase Chain: B: PDB Molecule:uroporphyrinogen-iii synthetase; PDBTitle: crystal structure of uroporphyrinogen iii synthase from pseudomonas2 syringae pv. tomato dc3000 Phyre2 PDB 4es6 chain A Region: 79 - 135 Aligned: 48 Modelled: 57 Confidence: 52.3% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:uroporphyrinogen-iii synthase; PDBTitle: crystal structure of hemd (pa5259) from pseudomonas aeruginosa (pao1)2 at 2.22 a resolution Phyre2 1 c6fkig_ 2 c3oaaO_ 3 c6q45G_ 4 c5dn6G_ 5 c6re1S_ 6 c2w6hG_ 7 c5lqxG_ 8 c6f5dG_ 9 c2xokG_ 10 c4xd7G_ 11 c5zwlG_ 12 c6focG_ 13 d2jdig1 14 d1fs0g_ 15 c2qe7G_ 16 c2w6jG_ 17 c3fksY_ 18 d1mabg_ 19 c3re1B_ 20 c4es6A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99