1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	H	Y	R	T	I	D	S	P	I	G	P	L	T	L	A	G	H	G	S	V	L	T	N	L	R	M	L	E	Q	T	Y	E	P	S	R	T	H	W	T	P	D	P	G	A	F	S	G	A	V	D	Q	L	N	A	Y	F	A	G
Secondary structure
SS confidence
Disorder		?	?	?																												?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	L	T	E	F	D	V	E	L	D	L	R	G	T	D	F	Q	Q	R	V	W	K	A	L	L	T	I	P	Y	G	E	T	R	S	Y	G	E	I	A	D	Q	I	G	A	P	G	A	A	R	A	V	G	L	A	N	G	H	N	P	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.
Sequence		A	I	I	V	P	C	H	R	V	I	G	A	S	G	K	L	T	G	Y	G	G	G	I	N	R	K	R	A	L	L	E	L	E	K	S	R	A	P	A	D	L	T	L	F	D
Secondary structure
SS confidence
Disorder													?		?	?	?	?	?	?																?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 35%) Beta strand ( 20%)

Rank Aligned region

PDB 4bhc chain A Region: 1 - 165 Aligned: 165 Modelled: 165 Confidence: 100.0% Identity: 99% PDB header:transferase Chain: A: PDB Molecule:methylated-dna--protein-cysteine methyltransferase; PDBTitle: crystal structure of the m. tuberculosis o6-methylguanine2 methyltransferase r37l variant Phyre2 PDB 1sfe chain A Region: 2 - 156 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 36% PDB header:dna-binding protein Chain: A: PDB Molecule:ada o6-methylguanine-dna methyltransferase; PDBTitle: ada o6-methylguanine-dna methyltransferase from escherichia coli Phyre2 PDB 4zye chain A Region: 1 - 158 Aligned: 150 Modelled: 158 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:methylated-dna--protein-cysteine methyltransferase; PDBTitle: crystal structure of sulfolobus solfataricus o6-methylguanine2 methyltransferase Phyre2 PDB 1wrj chain A Region: 1 - 157 Aligned: 149 Modelled: 157 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:methylated-dna--protein-cysteine PDBTitle: crystal structure of o6-methylguanine methyltransferase2 from sulfolobus tokodaii Phyre2 PDB 1t39 chain A Region: 2 - 156 Aligned: 142 Modelled: 155 Confidence: 100.0% Identity: 37% PDB header:transferase/dna Chain: A: PDB Molecule:methylated-dna--protein-cysteine PDBTitle: human o6-alkylguanine-dna alkyltransferase covalently2 crosslinked to dna Phyre2 PDB 2g7h chain A Region: 6 - 160 Aligned: 152 Modelled: 155 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:methylated-dna--protein-cysteine PDBTitle: structure of an o6-methylguanine dna methyltransferase from2 methanococcus jannaschii (mj1529) Phyre2 PDB 1mgt chain A Region: 5 - 155 Aligned: 148 Modelled: 151 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:protein (o6-methylguanine-dna methyltransferase); PDBTitle: crystal structure of o6-methylguanine-dna methyltransferase from2 hyperthermophilic archaeon pyrococcus kodakaraensis strain kod1 Phyre2 PDB 1sfe chain A domain 1 Region: 73 - 156 Aligned: 84 Modelled: 84 Confidence: 100.0% Identity: 52% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Phyre2 PDB 1qnt chain A domain 1 Region: 76 - 157 Aligned: 82 Modelled: 82 Confidence: 100.0% Identity: 44% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Phyre2 PDB 3gx4 chain X Region: 71 - 160 Aligned: 90 Modelled: 90 Confidence: 100.0% Identity: 37% PDB header:dna binding protein/dna Chain: X: PDB Molecule:alkyltransferase-like protein 1; PDBTitle: crystal structure analysis of s. pombe atl in complex with dna Phyre2 PDB 2kim chain A Region: 74 - 160 Aligned: 87 Modelled: 87 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:o6-methylguanine-dna methyltransferase; PDBTitle: 1.7-mm microcryoprobe solution nmr structure of an o6-methylguanine2 dna methyltransferase family protein from vibrio parahaemolyticus.3 northeast structural genomics consortium target vpr247. Phyre2 PDB 1mgt chain A domain 1 Region: 74 - 155 Aligned: 79 Modelled: 82 Confidence: 100.0% Identity: 39% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Phyre2 PDB 1sfe chain A domain 2 Region: 2 - 72 Aligned: 71 Modelled: 71 Confidence: 99.3% Identity: 17% Fold: Ribonuclease H-like motif Superfamily: Methylated DNA-protein cysteine methyltransferase domain Family: Methylated DNA-protein cysteine methyltransferase domain Phyre2 PDB 1qnt chain A domain 2 Region: 2 - 78 Aligned: 77 Modelled: 77 Confidence: 98.1% Identity: 26% Fold: Ribonuclease H-like motif Superfamily: Methylated DNA-protein cysteine methyltransferase domain Family: Methylated DNA-protein cysteine methyltransferase domain Phyre2 PDB 1dpu chain A Region: 74 - 115 Aligned: 40 Modelled: 42 Confidence: 76.1% Identity: 18% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: C-terminal domain of RPA32 Phyre2 PDB 1dpu chain A Region: 74 - 115 Aligned: 40 Modelled: 42 Confidence: 76.1% Identity: 18% PDB header:dna binding protein Chain: A: PDB Molecule:replication protein a (rpa32) c-terminal domain; PDBTitle: solution structure of the c-terminal domain of human rpa322 complexed with ung2(73-88) Phyre2 PDB 2gxb chain A domain 1 Region: 77 - 106 Aligned: 30 Modelled: 30 Confidence: 74.0% Identity: 23% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Z-DNA binding domain Phyre2 PDB 4lhf chain A Region: 91 - 123 Aligned: 31 Modelled: 33 Confidence: 71.4% Identity: 26% PDB header:viral protein Chain: A: PDB Molecule:regulatory protein cox; PDBTitle: crystal structure of a dna binding protein from phage p2 Phyre2 PDB 1qgp chain A Region: 75 - 106 Aligned: 32 Modelled: 32 Confidence: 69.5% Identity: 25% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Z-DNA binding domain Phyre2 PDB 3k69 chain A Region: 74 - 140 Aligned: 59 Modelled: 67 Confidence: 69.3% Identity: 24% PDB header:transcription Chain: A: PDB Molecule:putative transcription regulator; PDBTitle: crystal structure of a putative transcriptional regulator (lp_0360)2 from lactobacillus plantarum at 1.95 a resolution Phyre2 1 c4bhcA_ 2 c1sfeA_ 3 c4zyeA_ 4 c1wrjA_ 5 c1t39A_ 6 c2g7hA_ 7 c1mgtA_ 8 d1sfea1 9 d1qnta1 10 c3gx4X_ 11 c2kimA_ 12 d1mgta1 13 d1sfea2 14 d1qnta2 15 d1dpua_ 16 c1dpuA_ 17 d2gxba1 18 c4lhfA_ 19 d1qgpa_ 20 c3k69A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99