1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	R	V	R	L	V	I	A	Q	C	T	V	D	Y	I	G	R	L	T	A	H	L	P	S	A	R	R	L	L	L	F	K	A	D	G	S	V	S	V	H	A	D	D	R	A	Y	K	P	L	N	W	M	S	P	P	C	W	L	T
Secondary structure
SS confidence
Disorder		?	?	?															?	?	?	?	?	?	?																					?											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	E	S	G	G	Q	A	P	V	W	V	V	E	N	K	A	G	E	Q	L	R	I	T	I	E	G	I	E	H	D	S	S	H	E	L	G	V	D	P	G	L	V	K	D	G	V	E	A	H	L	Q	A	L	L	A	E	H	I	Q	L
Secondary structure
SS confidence
Disorder			?	?	?																																?	?	?		?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	G	E	G	Y	T	L	V	R	R	E	Y	M	T	A	I	G	P	V	D	L	L	C	S	D	E	R	G	G	S	V	A	V	E	I	K	R	R	G	E	I	D	G	V	E	Q	L	T	R	Y	L	E	L	L	N	R	D	S	V	L
Secondary structure
SS confidence
Disorder															?																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.
Sequence		A	P	V	K	G	V	F	A	A	Q	Q	I	K	P	Q	A	R	I	L	A	T	D	R	G	I	R	C	L	T	L	D	Y	D	T	M	R	G	M	D	S	G	E	Y	R	L	F
Secondary structure
SS confidence
Disorder																																						?			?	?	?	?		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 18%) Beta strand ( 49%)

Rank Aligned region

PDB 5gke chain B Region: 2 - 214 Aligned: 211 Modelled: 213 Confidence: 100.0% Identity: 27% PDB header:hydrolase/dna Chain: B: PDB Molecule:endonuclease endoms; PDBTitle: structure of endoms-dsdna1 complex Phyre2 PDB 2vld chain A Region: 2 - 212 Aligned: 201 Modelled: 200 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease nucs; PDBTitle: crystal structure of a repair endonuclease from pyrococcus abyssi Phyre2 PDB 1y88 chain A domain 2 Region: 122 - 220 Aligned: 95 Modelled: 99 Confidence: 96.8% Identity: 12% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: MRR-like Phyre2 PDB 3fov chain A Region: 120 - 189 Aligned: 69 Modelled: 70 Confidence: 96.3% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0102 protein rpa0323; PDBTitle: crystal structure of protein rpa0323 of unknown function from2 rhodopseudomonas palustris Phyre2 PDB 1y88 chain A Region: 122 - 217 Aligned: 95 Modelled: 96 Confidence: 96.2% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein af1548; PDBTitle: crystal structure of protein of unknown function af1548 Phyre2 PDB 1xmx chain A Region: 109 - 211 Aligned: 98 Modelled: 103 Confidence: 95.7% Identity: 13% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hypothetical protein VC1899 Phyre2 PDB 5zyu chain A Region: 127 - 188 Aligned: 61 Modelled: 62 Confidence: 95.0% Identity: 20% PDB header:dna binding protein/dna Chain: A: PDB Molecule:mitochondrial genome maintenance exonuclease 1; PDBTitle: the crytal struture of humanmgme1 with single strand dna2 Phyre2 PDB 4ic1 chain D Region: 108 - 179 Aligned: 72 Modelled: 72 Confidence: 94.7% Identity: 22% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of sso0001 Phyre2 PDB 4onb chain A Region: 137 - 179 Aligned: 42 Modelled: 43 Confidence: 93.8% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:crispr-associated exonuclease, cas4 family; PDBTitle: crystal structure of crispr-associated exonuclease (cas4 family) from2 pyrobaculum calidifontis jcm 11548 Phyre2 PDB 3u4q chain A Region: 137 - 188 Aligned: 51 Modelled: 52 Confidence: 93.3% Identity: 20% PDB header:hydrolase/dna Chain: A: PDB Molecule:atp-dependent helicase/nuclease subunit a; PDBTitle: structure of addab-dna complex at 2.8 angstroms Phyre2 PDB 3h1t chain A Region: 102 - 174 Aligned: 72 Modelled: 73 Confidence: 93.3% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:type i site-specific restriction-modification PDBTitle: the fragment structure of a putative hsdr subunit of a type2 i restriction enzyme from vibrio vulnificus yj016 Phyre2 PDB 3dnx chain A Region: 123 - 156 Aligned: 33 Modelled: 34 Confidence: 92.9% Identity: 30% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein spo1766; PDBTitle: spo1766 protein of unknown function from silicibacter pomeroyi. Phyre2 PDB 4oc8 chain A Region: 109 - 215 Aligned: 102 Modelled: 102 Confidence: 91.7% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease aspbhi; PDBTitle: dna modification-dependent restriction endonuclease aspbhi Phyre2 PDB 1w36 chain E Region: 137 - 176 Aligned: 39 Modelled: 40 Confidence: 88.7% Identity: 26% PDB header:recombination Chain: E: PDB Molecule:exodeoxyribonuclease v beta chain; PDBTitle: recbcd:dna complex Phyre2 PDB 2eo0 chain A Region: 107 - 174 Aligned: 59 Modelled: 68 Confidence: 88.6% Identity: 19% PDB header:dna binding protein Chain: A: PDB Molecule:hypothetical protein st1444; PDBTitle: crystal structure of holliday junction resolvase st1444 Phyre2 PDB 1gef chain A Region: 107 - 174 Aligned: 58 Modelled: 68 Confidence: 83.8% Identity: 24% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hjc-like Phyre2 PDB 2wj0 chain B Region: 107 - 174 Aligned: 58 Modelled: 68 Confidence: 83.5% Identity: 34% PDB header:hydrolase/dna Chain: B: PDB Molecule:archaeal hjc; PDBTitle: crystal structures of holliday junction resolvases from2 archaeoglobus fulgidus bound to dna substrate Phyre2 PDB 1hh1 chain A Region: 107 - 174 Aligned: 57 Modelled: 68 Confidence: 83.0% Identity: 23% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hjc-like Phyre2 PDB 4qbn chain A Region: 107 - 157 Aligned: 49 Modelled: 51 Confidence: 79.6% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:nuclease; PDBTitle: vrr_nuc domain Phyre2 PDB 1ob8 chain A Region: 107 - 172 Aligned: 56 Modelled: 66 Confidence: 79.4% Identity: 29% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Hjc-like Phyre2 1 c5gkeB_ 2 c2vldA_ 3 d1y88a2 4 c3fovA_ 5 c1y88A_ 6 d1xmxa_ 7 c5zyuA_ 8 c4ic1D_ 9 c4onbA_ 10 c3u4qA_ 11 c3h1tA_ 12 c3dnxA_ 13 c4oc8A_ 14 c1w36E_ 15 c2eo0A_ 16 d1gefa_ 17 c2wj0B_ 18 d1hh1a_ 19 c4qbnA_ 20 d1ob8a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99