1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	L	R	K	G	T	V	Y	V	L	V	I	R	A	D	L	V	N	A	M	V	A	H	A	R	R	D	H	P	D	E	A	C	G	V	L	A	G	P	E	G	S	D	R	P	E	R	H	I	P	M	T	N	A	E	R	S	P	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	Y	R	L	D	S	G	E	Q	L	K	V	W	R	A	M	E	D	A	D	E	V	P	V	V	I	Y	H	S	H	T	A	T	E	A	Y	P	S	R	T	D	V	K	L	A	T	E	P	D	A	H	Y	V	L	V	S	T	R	D	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.
Sequence		H	R	H	E	L	R	S	Y	R	I	V	D	G	A	V	T	E	E	P	V	N	V	V	E	Q	Y
Secondary structure
SS confidence
Disorder														?										?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 23%) Beta strand ( 43%)

Rank Aligned region

PDB 2kks chain A Region: 10 - 146 Aligned: 137 Modelled: 137 Confidence: 100.0% Identity: 34% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of protein dsy2949 from desulfitobacterium2 hafniense. northeast structural genomics consortium target dhr27 Phyre2 PDB 2kcq chain A Region: 11 - 146 Aligned: 136 Modelled: 136 Confidence: 100.0% Identity: 28% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:mov34/mpn/pad-1 family; PDBTitle: solution structure of protein sru_2040 from salinibacter2 ruber (strain dsm 13855) . northeast structural genomics3 consortium target srr106 Phyre2 PDB 5ld9 chain B Region: 10 - 141 Aligned: 125 Modelled: 128 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:jamm1; PDBTitle: structure of deubiquitinating enzyme homolog, pyrococcus furiosus2 jamm1. Phyre2 PDB 5cw6 chain A Region: 7 - 142 Aligned: 133 Modelled: 130 Confidence: 100.0% Identity: 18% PDB header:metal binding protein Chain: A: PDB Molecule:drbrcc36; PDBTitle: structure of metal dependent enzyme drbrcc36 Phyre2 PDB 1oi0 chain A Region: 11 - 140 Aligned: 104 Modelled: 108 Confidence: 99.9% Identity: 24% Fold: Cytidine deaminase-like Superfamily: JAB1/MPN domain Family: JAB1/MPN domain Phyre2 PDB 6fnn chain B Region: 11 - 140 Aligned: 129 Modelled: 130 Confidence: 99.9% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:26s proteasome regulatory subunit n11-like protein; PDBTitle: caldiarchaeum subterraneum ubiquitin:rpn11-homolog complex Phyre2 PDB 6r8f chain A Region: 11 - 134 Aligned: 123 Modelled: 124 Confidence: 99.9% Identity: 15% PDB header:signaling protein Chain: A: PDB Molecule:lys-63-specific deubiquitinase brcc36; PDBTitle: cryo-em structure of the human brisc-shmt2 complex Phyre2 PDB 6fju chain A Region: 11 - 131 Aligned: 121 Modelled: 121 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:26s proteasome regulatory subunit n11-like protein; PDBTitle: rpn11 homolog from caldiarchaeum subterraneum Phyre2 PDB 5cw4 chain C Region: 11 - 134 Aligned: 120 Modelled: 124 Confidence: 99.9% Identity: 16% PDB header:metal binding protein Chain: C: PDB Molecule:brca1/brca2-containing complex subunit 3; PDBTitle: structure of cfbrcc36-cfkiaa0157 complex (selenium edge) Phyre2 PDB 4b4t chain V Region: 4 - 130 Aligned: 127 Modelled: 127 Confidence: 99.9% Identity: 23% PDB header:hydrolase Chain: V: PDB Molecule:26s proteasome regulatory subunit rpn11; PDBTitle: near-atomic resolution structural model of the yeast 26s proteasome Phyre2 PDB 4d18 chain E Region: 11 - 134 Aligned: 123 Modelled: 124 Confidence: 99.9% Identity: 19% PDB header:signaling protein Chain: E: PDB Molecule:cop9 signalosome complex subunit 5; PDBTitle: crystal structure of the cop9 signalosome Phyre2 PDB 5gjq chain V Region: 11 - 142 Aligned: 132 Modelled: 132 Confidence: 99.9% Identity: 21% PDB header:hydrolase Chain: V: PDB Molecule:26s proteasome non-atpase regulatory subunit 14; PDBTitle: structure of the human 26s proteasome bound to usp14-ubal Phyre2 PDB 2znr chain A Region: 11 - 132 Aligned: 116 Modelled: 122 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:amsh-like protease; PDBTitle: crystal structure of the dub domain of human amsh-lp Phyre2 PDB 4k1r chain A Region: 11 - 132 Aligned: 116 Modelled: 122 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:amsh-like protease sst2; PDBTitle: crystal structure of schizosaccharomyces pombe sst2 catalytic domain2 and ubiquitin Phyre2 PDB 4f7o chain B Region: 11 - 134 Aligned: 124 Modelled: 124 Confidence: 99.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:cop9 signalosome complex subunit 5; PDBTitle: crystal structure of csn5 Phyre2 PDB 3j7k chain H Region: 11 - 142 Aligned: 130 Modelled: 132 Confidence: 99.7% Identity: 18% PDB header:translation Chain: H: PDB Molecule:eukaryotic translation initiation factor 3 subunit h; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s em map Phyre2 PDB 3j7j chain H Region: 11 - 142 Aligned: 130 Modelled: 131 Confidence: 99.7% Identity: 18% PDB header:translation Chain: H: PDB Molecule:eukaryotic translation initiation factor 3 subunit h; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s-hcv ires2 em map Phyre2 PDB 3j8c chain H Region: 11 - 142 Aligned: 130 Modelled: 132 Confidence: 99.7% Identity: 18% PDB header:translation Chain: H: PDB Molecule:eukaryotic translation initiation factor 3 subunit h; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s em map Phyre2 PDB 3j8b chain H Region: 11 - 142 Aligned: 130 Modelled: 131 Confidence: 99.7% Identity: 18% PDB header:translation Chain: H: PDB Molecule:eukaryotic translation initiation factor 3 subunit h; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s-hcv ires2 em map Phyre2 PDB 5a5t chain H Region: 4 - 132 Aligned: 127 Modelled: 129 Confidence: 99.6% Identity: 17% PDB header:hydrolase Chain: H: PDB Molecule:eukaryotic translation initiation factor 3 subunit h; PDBTitle: structure of mammalian eif3 in the context of the 43s preinitiation2 complex Phyre2 1 c2kksA_ 2 c2kcqA_ 3 c5ld9B_ 4 c5cw6A_ 5 d1oi0a_ 6 c6fnnB_ 7 c6r8fA_ 8 c6fjuA_ 9 c5cw4C_ 10 c4b4tV_ 11 c4d18E_ 12 c5gjqV_ 13 c2znrA_ 14 c4k1rA_ 15 c4f7oB_ 16 c3j7kH_ 17 c3j7jH_ 18 c3j8cH_ 19 c3j8bH_ 20 c5a5tH_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99