1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	M	T	P	R	R	K	R	R	G	G	A	V	Q	I	T	R	P	T	G	R	P	R	T	P	T	T	Q	T	T	K	R	P	R	W	V	V	G	G	T	T	I	L	T	F	V	A	L	L	Y	L	V	E	L	I	D	Q	L	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	S	R	L	D	V	N	G	I	R	P	L	K	T	D	G	L	W	G	V	I	F	A	P	L	L	H	A	N	W	H	H	L	M	A	N	T	I	P	L	L	V	L	G	F	L	M	T	L	A	G	L	S	R	F	V	W	A	T	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	I	W	I	L	G	G	L	G	T	W	L	I	G	N	V	G	S	S	C	G	P	T	D	H	I	G	A	S	G	L	I	F	G	W	L	A	F	L	L	V	F	G	L	F	V	R	K	G	W	D	I	V	I	G	L	V	V	L	F
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?	?																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	Y	G	G	I	L	L	G	A	M	P	V	L	G	Q	C	G	G	V	S	W	Q	G	H	L	S	G	A	V	A	G	V	V	A	A	Y	L	L	S	A	P	E	R	K	A	R	A	L	K	R	A	G	A	R	S	G	H	P	K	L
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?																									?	?	?	?					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 75%) Beta strand ( 0%) TM helix ( 44%) (View membrane topology prediction)

Rank Aligned region

PDB 3b45 chain A domain 1 Region: 33 - 219 Aligned: 178 Modelled: 187 Confidence: 100.0% Identity: 17% Fold: Rhomboid-like Superfamily: Rhomboid-like Family: Rhomboid-like Phyre2 PDB 2nr9 chain A domain 1 Region: 32 - 227 Aligned: 187 Modelled: 196 Confidence: 99.9% Identity: 14% Fold: Rhomboid-like Superfamily: Rhomboid-like Family: Rhomboid-like Phyre2 PDB 2gfp chain A Region: 93 - 240 Aligned: 148 Modelled: 148 Confidence: 79.6% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 4zp0 chain A Region: 30 - 235 Aligned: 195 Modelled: 206 Confidence: 65.4% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 6e9o chain A Region: 30 - 234 Aligned: 194 Modelled: 205 Confidence: 55.5% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 4iu8 chain A Region: 22 - 192 Aligned: 160 Modelled: 170 Confidence: 29.2% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 3wdo chain A Region: 28 - 237 Aligned: 199 Modelled: 210 Confidence: 28.0% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 6h7d chain A Region: 93 - 218 Aligned: 126 Modelled: 126 Confidence: 27.3% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 1pw4 chain A Region: 18 - 239 Aligned: 214 Modelled: 222 Confidence: 23.5% Identity: 9% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 6g9x chain B Region: 93 - 234 Aligned: 142 Modelled: 142 Confidence: 19.7% Identity: 12% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 5guf chain A Region: 196 - 218 Aligned: 23 Modelled: 23 Confidence: 19.4% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:cdp-archaeol synthase; PDBTitle: structural insight into an intramembrane enzyme for archaeal membrane2 lipids biosynthesis Phyre2 PDB 4lds chain B Region: 42 - 239 Aligned: 191 Modelled: 198 Confidence: 11.9% Identity: 16% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 5xpd chain A Region: 81 - 238 Aligned: 157 Modelled: 158 Confidence: 11.5% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:sugar transporter; PDBTitle: sugar transporter of atsweet13 in inward-facing state with a substrate2 analog Phyre2 PDB 4j05 chain A Region: 34 - 157 Aligned: 117 Modelled: 124 Confidence: 7.6% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 2b6p chain A Region: 205 - 239 Aligned: 35 Modelled: 35 Confidence: 5.7% Identity: 9% PDB header:membrane protein Chain: A: PDB Molecule:lens fiber major intrinsic protein; PDBTitle: x-ray structure of lens aquaporin-0 (aqp0) (lens mip) in an open pore2 state Phyre2 1 d3b45a1 2 d2nr9a1 3 c2gfpA_ 4 c4zp0A_ 5 c6e9oA_ 6 c4iu8A_ 7 c3wdoA_ 8 c6h7dA_ 9 d1pw4a_ 10 c6g9xB_ 11 c5gufA_ 12 c4ldsB_ 13 c5xpdA_ 14 c4j05A_ 15 c2b6pA_