1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	V	V	A	L	V	G	S	A	I	V	D	L	H	S	R	P	P	W	S	N	N	A	V	R	R	L	G	V	A	L	R	D	G	V	D	P	P	V	D	C	P	S	Y	A	E	V	M	L	W	H	A	D	L	A	A	E	V	Q	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?				?	?	?			?	?	?	?	?													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	I	E	G	R	S	W	S	A	S	E	L	L	V	T	S	R	A	K	S	Q	D	T	L	L	A	K	L	R	R	R	P	Y	L	Q	L	N	T	I	Q	D	I	A	G	V	R	I	D	A	D	L	L	L	G	E	Q	T	R	L	A
Secondary structure
SS confidence
Disorder						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	E	I	A	D	H	F	G	A	D	Q	P	A	I	H	D	L	R	D	H	P	H	A	G	Y	R	A	V	H	V	W	L	R	L	P	A	G	R	V	E	I	Q	I	R	T	I	L	Q	S	L	W	A	N	F	Y	E	L	L	A	D
Secondary structure
SS confidence
Disorder												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	Y	G	R	G	I	R	Y	D	E	R	P	E	Q	L	A	A	G	V	V	P	A	Q	L	Q	E	L	V	G	V	M	Q	D	A	S	A	D	L	A	M	H	E	A	E	W	Q	H	C	A	E	I	E	Y	P	G	Q	R	A	M	A
Secondary structure
SS confidence
Disorder							?	?	?	?	?																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.
Sequence		L	G	E	A	S	K	N	K	A	T	V	L	A	T	T	K	F	R	L	E	R	A	I	N	E	A	E	S	A	G	G	G	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?											?	?		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 60%) Beta strand ( 12%)

Rank Aligned region

PDB 5xnx chain B Region: 6 - 174 Aligned: 166 Modelled: 169 Confidence: 100.0% Identity: 20% PDB header:hydrolase, transferase Chain: B: PDB Molecule:bifunctional (p)ppgpp synthase/hydrolase rela; PDBTitle: crystallographic structure of the enzymatically active n-terminal2 domain of the rel protein from mycobacterium tuberculosis Phyre2 PDB 1vj7 chain B Region: 6 - 174 Aligned: 158 Modelled: 169 Confidence: 100.0% Identity: 18% PDB header:hydrolase, transferase Chain: B: PDB Molecule:bifunctional rela/spot; PDBTitle: crystal structure of the bifunctional catalytic fragment of relseq,2 the rela/spot homolog from streptococcus equisimilis. Phyre2 PDB 5ded chain A Region: 42 - 235 Aligned: 176 Modelled: 194 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:gtp pyrophosphokinase yjbm; PDBTitle: crystal structure of the small alarmone synthethase 1 from bacillus2 subtilis bound to its product pppgpp Phyre2 PDB 1vj7 chain A domain 2 Region: 42 - 174 Aligned: 131 Modelled: 133 Confidence: 100.0% Identity: 20% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: RelA/SpoT domain Phyre2 PDB 6fgk chain A Region: 42 - 230 Aligned: 169 Modelled: 184 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:gtp pyrophosphokinase ywac; PDBTitle: crystal structure of the small alarmone synthethase 2 from bacillus2 subtilis Phyre2 PDB 3l9d chain A Region: 38 - 239 Aligned: 184 Modelled: 202 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:putative gtp pyrophosphokinase; PDBTitle: the crystal structure of smu.1046c from streptococcus mutans ua159 Phyre2 PDB 2be3 chain A domain 1 Region: 41 - 239 Aligned: 181 Modelled: 191 Confidence: 100.0% Identity: 19% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: RelA/SpoT domain Phyre2 PDB 6ex0 chain B Region: 42 - 234 Aligned: 172 Modelled: 186 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:gtp pyrophosphokinase; PDBTitle: crystal structure of relp (sas2) from staphylococcus aureus bound to2 pppgpp in the post-catalytic state Phyre2 PDB 3u24 chain A Region: 171 - 237 Aligned: 59 Modelled: 61 Confidence: 65.7% Identity: 17% PDB header:lipid binding protein Chain: A: PDB Molecule:putative lipoprotein; PDBTitle: the structure of a putative lipoprotein of unknown function from2 shewanella oneidensis. Phyre2 PDB 1g71 chain A Region: 98 - 152 Aligned: 48 Modelled: 55 Confidence: 36.0% Identity: 15% Fold: Prim-pol domain Superfamily: Prim-pol domain Family: PriA-like Phyre2 PDB 4nf9 chain A Region: 145 - 230 Aligned: 81 Modelled: 86 Confidence: 29.4% Identity: 12% PDB header:cell cycle Chain: A: PDB Molecule:protein casc5; PDBTitle: structure of the knl1/nsl1 complex Phyre2 PDB 5suh chain B Region: 10 - 56 Aligned: 44 Modelled: 47 Confidence: 25.4% Identity: 27% PDB header:structural protein Chain: B: PDB Molecule:msm0271 protein; PDBTitle: the structure of double ringed trimeric shell protein msm0271 from the2 rmm microcompartment Phyre2 PDB 4ht7 chain G Region: 10 - 56 Aligned: 44 Modelled: 47 Confidence: 23.0% Identity: 18% PDB header:protein binding Chain: G: PDB Molecule:co2 concentrating mechanism protein p; PDBTitle: co2 concentrating mechanism protein p, ccmp form 2 Phyre2 PDB 4ern chain A Region: 5 - 34 Aligned: 30 Modelled: 30 Confidence: 22.2% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:tfiih basal transcription factor complex helicase xpb PDBTitle: crystal structure of the c-terminal domain of human xpb/ercc-32 excision repair protein at 1.80 a Phyre2 PDB 5v75 chain E Region: 10 - 56 Aligned: 44 Modelled: 47 Confidence: 19.5% Identity: 11% PDB header:structural protein Chain: E: PDB Molecule:microcompartments protein; PDBTitle: structure of haliangium ochraceum bmc-t ho-5816 Phyre2 PDB 3o0y chain C Region: 171 - 237 Aligned: 59 Modelled: 62 Confidence: 18.1% Identity: 24% PDB header:lipid binding protein Chain: C: PDB Molecule:lipoprotein; PDBTitle: the crystal structure of the putative lipoprotein from colwellia2 psychrerythraea Phyre2 PDB 5v76 chain A Region: 10 - 56 Aligned: 44 Modelled: 47 Confidence: 17.1% Identity: 16% PDB header:structural protein Chain: A: PDB Molecule:microcompartments protein; PDBTitle: structure of haliangium ochraceum bmc-t ho-3341 Phyre2 PDB 2bi7 chain A domain 2 Region: 144 - 153 Aligned: 10 Modelled: 10 Confidence: 14.3% Identity: 30% Fold: FAD-linked reductases, C-terminal domain Superfamily: FAD-linked reductases, C-terminal domain Family: UDP-galactopyranose mutase Phyre2 PDB 1v33 chain A Region: 98 - 152 Aligned: 48 Modelled: 55 Confidence: 14.0% Identity: 17% Fold: Prim-pol domain Superfamily: Prim-pol domain Family: PriA-like Phyre2 PDB 1m55 chain A Region: 116 - 156 Aligned: 41 Modelled: 41 Confidence: 12.4% Identity: 10% Fold: Origin of replication-binding domain, RBD-like Superfamily: Origin of replication-binding domain, RBD-like Family: Replication protein Rep, nuclease domain Phyre2 1 c5xnxB_ 2 c1vj7B_ 3 c5dedA_ 4 d1vj7a2 5 c6fgkA_ 6 c3l9dA_ 7 d2be3a1 8 c6ex0B_ 9 c3u24A_ 10 d1g71a_ 11 c4nf9A_ 12 c5suhB_ 13 c4ht7G_ 14 c4ernA_ 15 c5v75E_ 16 c3o0yC_ 17 c5v76A_ 18 d2bi7a2 19 d1v33a_ 20 d1m55a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65