1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	S	E	H	P	M	T	D	R	V	V	Y	R	S	L	M	A	D	N	L	R	W	D	A	L	Q	L	R	D	G	D	I	I	I	S	A	P	S	K	S	G	L	T	W	T	Q	R	L	V	S	L	L	V	F	D	G	P	D	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	P	L	S	T	V	S	P	W	L	D	Q	T	I	R	P	I	E	E	V	V	A	T	L	D	A	Q	Q	H	R	R	F	I	K	T	H	T	P	L	D	G	L	V	L	D	D	R	V	S	Y	I	C	V	G	R	D	P	R	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	V	S	M	L	Y	Q	S	A	N	M	N	E	D	R	M	R	I	L	H	E	A	V	V	P	F	H	E	R	I	A	P	P	F	A	E	L	G	H	A	R	S	P	T	E	E	F	R	D	W	M	E	G	P	N	Q	P	P	P
Secondary structure
SS confidence
Disorder												?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?										?	?			?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	I	G	F	T	H	L	K	G	I	G	T	L	A	N	I	L	H	Q	L	G	T	V	W	V	R	R	H	L	P	N	V	A	L	F	H	Y	A	D	Y	Q	A	D	L	A	G	E	L	L	R	P	A	R	V	L	G	I	A	A	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		R	D	R	A	R	D	L	A	Q	Y	A	T	L	D	A	M	R	S	R	A	S	E	I	A	P	N	T	T	D	G	I	W	H	S	D	E	R	F	F	R	R	G	G	S	G	D	W	Q	Q	F	F	T	E	A	E	H	L	R	Y	Y
Secondary structure
SS confidence
Disorder																			?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.
Sequence		H	R	I	N	Q	L	A	P	P	D	L	L	A	W	A	H	E	G	R	R	G	Y	D	P	A	N
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 48%) Beta strand ( 6%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 5mek chain A Region: 5 - 308 Aligned: 265 Modelled: 267 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:cytosolic sulfotransferase 18; PDBTitle: sulphotransferase-18 from arabidopsis thaliana in complex with 3'-2 phosphoadenosine 5'-phosphate (pap) Phyre2 PDB 1fmj chain A Region: 11 - 308 Aligned: 260 Modelled: 260 Confidence: 100.0% Identity: 28% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1g3m chain A Region: 25 - 309 Aligned: 247 Modelled: 247 Confidence: 100.0% Identity: 24% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 2h8k chain A Region: 24 - 308 Aligned: 211 Modelled: 211 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:sult1c3 splice variant d; PDBTitle: human sulfotranferase sult1c3 in complex with pap Phyre2 PDB 3u3o chain A Region: 23 - 308 Aligned: 248 Modelled: 248 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1a1; PDBTitle: crystal structure of human sult1a1 bound to pap and two 3-cyano-7-2 hydroxycoumarin Phyre2 PDB 1ls6 chain A Region: 23 - 308 Aligned: 248 Modelled: 248 Confidence: 100.0% Identity: 23% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 2zvp chain X Region: 25 - 309 Aligned: 247 Modelled: 247 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: X: PDB Molecule:tyrosine-ester sulfotransferase; PDBTitle: crystal structure of mouse cytosolic sulfotransferase msult1d1 complex2 with pap and p-nitrophenol Phyre2 PDB 1xv1 chain A Region: 24 - 308 Aligned: 247 Modelled: 247 Confidence: 100.0% Identity: 21% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1q20 chain A Region: 22 - 307 Aligned: 246 Modelled: 248 Confidence: 100.0% Identity: 24% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1j99 chain A Region: 22 - 314 Aligned: 253 Modelled: 255 Confidence: 100.0% Identity: 23% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 2a3r chain A domain 1 Region: 13 - 309 Aligned: 259 Modelled: 259 Confidence: 100.0% Identity: 23% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1aqu chain A Region: 25 - 308 Aligned: 242 Modelled: 246 Confidence: 100.0% Identity: 22% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 5x2b chain K Region: 12 - 320 Aligned: 261 Modelled: 271 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: K: PDB Molecule:sulfotransferase; PDBTitle: crystal structure of mouse sulfotransferase sult7a1 complexed with pap Phyre2 PDB 1q44 chain A Region: 22 - 308 Aligned: 210 Modelled: 212 Confidence: 100.0% Identity: 23% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 2gwh chain A Region: 25 - 308 Aligned: 246 Modelled: 246 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase 1c2; PDBTitle: human sulfotranferase sult1c2 in complex with pap and2 pentachlorophenol Phyre2 PDB 1q1q chain A Region: 22 - 307 Aligned: 236 Modelled: 236 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:sulfotransferase family, cytosolic, 2b, member 1 isoform a; PDBTitle: crystal structure of human pregnenolone sulfotransferase (sult2b1a) in2 the presence of pap Phyre2 PDB 3bfx chain A domain 1 Region: 25 - 308 Aligned: 218 Modelled: 228 Confidence: 100.0% Identity: 23% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: PAPS sulfotransferase Phyre2 PDB 1zd1 chain B Region: 23 - 309 Aligned: 213 Modelled: 240 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:sulfotransferase 4a1; PDBTitle: human sulfortransferase sult4a1 Phyre2 PDB 3mgb chain A Region: 12 - 321 Aligned: 271 Modelled: 274 Confidence: 100.0% Identity: 16% PDB header:transferase/antibiotic Chain: A: PDB Molecule:teg12; PDBTitle: teg 12 ternary structure complexed with pap and the teicoplanin2 aglycone Phyre2 PDB 3mg9 chain A Region: 30 - 308 Aligned: 236 Modelled: 254 Confidence: 100.0% Identity: 16% PDB header:transferase/antibiotic Chain: A: PDB Molecule:teg12; PDBTitle: teg 12 binary structure complexed with the teicoplanin aglycone Phyre2 1 c5mekA_ 2 d1fmja_ 3 d1g3ma_ 4 c2h8kA_ 5 c3u3oA_ 6 d1ls6a_ 7 c2zvpX_ 8 d1xv1a_ 9 d1q20a_ 10 d1j99a_ 11 d2a3ra1 12 d1aqua_ 13 c5x2bK_ 14 d1q44a_ 15 c2gwhA_ 16 c1q1qA_ 17 d3bfxa1 18 c1zd1B_ 19 c3mgbA_ 20 c3mg9A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99