1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	S	G	T	L	A	G	S	L	I	F	A	A	V	L	V	M	L	I	A	V	L	A	R	L	M	M	R	G	W	R	R	R	S	E	R	Q	A	E	L	L	G	D	L	P	D	V	P	E	H	V	S	S	A	T	V	T	T	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																													?	?	?	?	?	?	?	?	?			?	?	?	?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	L	Y	V	G	A	T	L	S	P	A	W	N	E	R	V	T	V	G	D	L	G	Y	R	S	K	A	V	L	T	R	Y	P	S	G	I	M	V	E	R	A	R	A	Q	P	I	W	I	P	T	E	S	I	A	A	I	R	M	E	R
Secondary structure
SS confidence
Disorder																																																							?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.
Sequence		G	V	A	G	K	V	V	A	G	I	G	I	L	A	I	R	W	R	L	P	S	G	T	E	I	D	V	G	F	R	A	D	N	R	D	E	Y	Q	E	W	L	E	E	P	V
Secondary structure
SS confidence
Disorder																																											?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 34%) Beta strand ( 32%) TM helix ( 10%) (View membrane topology prediction)

Rank Aligned region

PDB 2oar chain A domain 1 Region: 8 - 47 Aligned: 40 Modelled: 40 Confidence: 48.4% Identity: 18% Fold: Gated mechanosensitive channel Superfamily: Gated mechanosensitive channel Family: Gated mechanosensitive channel Phyre2 PDB 2oar chain A Region: 8 - 52 Aligned: 44 Modelled: 45 Confidence: 31.2% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: mechanosensitive channel of large conductance (mscl) Phyre2 PDB 6adq chain P Region: 10 - 33 Aligned: 24 Modelled: 24 Confidence: 26.2% Identity: 46% PDB header:electron transport Chain: P: PDB Molecule:prokaryotic respiratory supercomplex associate factor 1 PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 2mic chain B Region: 11 - 36 Aligned: 26 Modelled: 26 Confidence: 22.9% Identity: 31% PDB header:membrane protein Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 PDB 2mic chain A Region: 11 - 36 Aligned: 26 Modelled: 26 Confidence: 22.9% Identity: 31% PDB header:membrane protein Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 PDB 4cdi chain C Region: 6 - 30 Aligned: 25 Modelled: 25 Confidence: 22.6% Identity: 28% PDB header:membrane protein Chain: C: PDB Molecule:predicted protein; PDBTitle: crystal structure of acrb-acrz complex Phyre2 PDB 2grx chain B Region: 48 - 121 Aligned: 73 Modelled: 74 Confidence: 18.7% Identity: 16% PDB header:metal transport Chain: B: PDB Molecule:ferrichrome-iron receptor; PDBTitle: crystal structure of tonb in complex with fhua, e. coli2 outer membrane receptor for ferrichrome Phyre2 PDB 3ts3 chain D Region: 44 - 104 Aligned: 61 Modelled: 61 Confidence: 17.8% Identity: 30% PDB header:viral protein Chain: D: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the turkey astrovirus2 capsid protein at 1.5 angstrom resolution Phyre2 PDB 2low chain A Region: 5 - 35 Aligned: 31 Modelled: 31 Confidence: 15.8% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:apelin receptor; PDBTitle: solution structure of ar55 in 50% hfip Phyre2 PDB 2lp1 chain A Region: 2 - 28 Aligned: 27 Modelled: 27 Confidence: 15.1% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:c99; PDBTitle: the solution nmr structure of the transmembrane c-terminal domain of2 the amyloid precursor protein (c99) Phyre2 PDB 3hzq chain A Region: 8 - 38 Aligned: 31 Modelled: 31 Confidence: 14.8% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: structure of a tetrameric mscl in an expanded intermediate state Phyre2 PDB 2xfv chain B Region: 95 - 112 Aligned: 18 Modelled: 18 Confidence: 14.2% Identity: 33% PDB header:cell-cycle Chain: B: PDB Molecule:regulatory protein swi6; PDBTitle: structure of the amino-terminal domain from the cell-cycle2 regulator swi6 Phyre2 PDB 1eyq chain A Region: 80 - 99 Aligned: 20 Modelled: 20 Confidence: 14.2% Identity: 20% Fold: Chalcone isomerase Superfamily: Chalcone isomerase Family: Chalcone isomerase Phyre2 PDB 3t2d chain A Region: 111 - 135 Aligned: 25 Modelled: 25 Confidence: 13.4% Identity: 12% PDB header:lyase, hydrolase Chain: A: PDB Molecule:fructose-1,6-bisphosphate aldolase/phosphatase; PDBTitle: fructose-1,6-bisphosphate aldolase/phosphatase from thermoproteus2 neutrophilus, fbp-bound form Phyre2 PDB 4doi chain B Region: 80 - 99 Aligned: 20 Modelled: 20 Confidence: 13.1% Identity: 20% PDB header:isomerase Chain: B: PDB Molecule:chalcone--flavonone isomerase 1; PDBTitle: crystal structure of arabidopsis thaliana chalcone isomerase at3g551202 (atchi) Phyre2 PDB 5yx4 chain A Region: 80 - 99 Aligned: 20 Modelled: 20 Confidence: 12.7% Identity: 15% PDB header:isomerase Chain: A: PDB Molecule:chalcone-flavonone isomerase family protein; PDBTitle: isoliquiritigenin-complexed chalcone isomerase (s189a) from the2 antarctic vascular plant deschampsia antarctica (dachi1) Phyre2 PDB 4dok chain A Region: 80 - 99 Aligned: 20 Modelled: 20 Confidence: 12.4% Identity: 10% PDB header:isomerase Chain: A: PDB Molecule:similarity to chalcone-flavonone isomerase; PDBTitle: crystal structure of arabidopsis thaliana chalcone-isomerase like2 protein at5g05270 (atchil) Phyre2 PDB 2ix0 chain A domain 3 Region: 96 - 119 Aligned: 23 Modelled: 24 Confidence: 11.7% Identity: 26% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 1a62 chain A domain 2 Region: 85 - 129 Aligned: 45 Modelled: 45 Confidence: 11.3% Identity: 24% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 2ix0 chain A domain 2 Region: 97 - 116 Aligned: 20 Modelled: 20 Confidence: 10.9% Identity: 15% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 1 d2oara1 2 c2oarA_ 3 c6adqP_ 4 c2micB_ 5 c2micA_ 6 c4cdiC_ 7 c2grxB_ 8 c3ts3D_ 9 c2lowA_ 10 c2lp1A_ 11 c3hzqA_ 12 c2xfvB_ 13 d1eyqa_ 14 c3t2dA_ 15 c4doiB_ 16 c5yx4A_ 17 c4dokA_ 18 d2ix0a3 19 d1a62a2 20 d2ix0a2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57