1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	E	K	G	R	L	F	T	S	E	S	V	T	E	G	H	P	D	K	I	C	D	A	I	S	D	S	V	L	D	A	L	L	A	A	D	P	R	S	R	V	A	V	E	T	L	V	T	T	G	Q	V	H	V	V	G	E	V	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	S	A	K	E	A	F	A	D	I	T	N	T	V	R	A	R	I	L	E	I	G	Y	D	S	S	D	K	G	F	D	G	A	T	C	G	V	N	I	G	I	G	A	Q	S	P	D	I	A	Q	G	V	D	T	A	H	E	A	R	V
Secondary structure
SS confidence
Disorder						?																					?																														?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	G	A	A	D	P	L	D	S	Q	G	A	G	D	Q	G	L	M	F	G	Y	A	I	N	A	T	P	E	L	M	P	L	P	I	A	L	A	H	R	L	S	R	R	L	T	E	V	R	K	N	G	V	L	P	Y	L	R	P	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		K	T	Q	V	T	I	A	Y	E	D	N	V	P	V	R	L	D	T	V	V	I	S	T	Q	H	A	A	D	I	D	L	E	K	T	L	D	P	D	I	R	E	K	V	L	N	T	V	L	D	D	L	A	H	E	T	L	D	A	S	T
Secondary structure
SS confidence
Disorder																											?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	R	V	L	V	N	P	T	G	K	F	V	L	G	G	P	M	G	D	A	G	L	T	G	R	K	I	I	V	D	T	Y	G	G	W	A	R	H	G	G	G	A	F	S	G	K	D	P	S	K	V	D	R	S	A	A	Y	A	M	R
Secondary structure
SS confidence
Disorder																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		W	V	A	K	N	V	V	A	A	G	L	A	E	R	V	E	V	Q	V	A	Y	A	I	G	K	A	A	P	V	G	L	F	V	E	T	F	G	T	E	T	E	D	P	V	K	I	E	K	A	I	G	E	V	F	D	L	R	P	G	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.
Sequence		I	I	R	D	L	N	L	L	R	P	I	Y	A	P	T	A	A	Y	G	H	F	G	R	T	D	V	E	L	P	W	E	Q	L	D	K	V	D	D	L	K	R	A	I
Secondary structure
SS confidence
Disorder																																											?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 34%) Beta strand ( 23%)

Rank Aligned region

PDB 5h9u chain C Region: 3 - 402 Aligned: 390 Modelled: 390 Confidence: 100.0% Identity: 59% PDB header:transferase Chain: C: PDB Molecule:s-adenosylmethionine synthase; PDBTitle: crystal structure of a thermostable methionine adenosyltransferase Phyre2 PDB 1rg9 chain D Region: 4 - 403 Aligned: 380 Modelled: 380 Confidence: 100.0% Identity: 61% PDB header:transferase Chain: D: PDB Molecule:s-adenosylmethionine synthetase; PDBTitle: s-adenosylmethionine synthetase complexed with sam and ppnp Phyre2 PDB 3rv2 chain B Region: 5 - 403 Aligned: 373 Modelled: 373 Confidence: 100.0% Identity: 95% PDB header:transferase Chain: B: PDB Molecule:s-adenosylmethionine synthase; PDBTitle: crystal structure of s-adenosylmethionine synthetase from2 mycobacterium marinum Phyre2 PDB 2obv chain A Region: 1 - 397 Aligned: 378 Modelled: 378 Confidence: 100.0% Identity: 55% PDB header:transferase Chain: A: PDB Molecule:s-adenosylmethionine synthetase isoform type-1; PDBTitle: crystal structure of the human s-adenosylmethionine synthetase 1 in2 complex with the product Phyre2 PDB 4odj chain A Region: 4 - 397 Aligned: 377 Modelled: 377 Confidence: 100.0% Identity: 51% PDB header:transferase Chain: A: PDB Molecule:s-adenosylmethionine synthase; PDBTitle: crystal structure of a putative s-adenosylmethionine synthetase from2 cryptosporidium hominis in complex with s-adenosyl-methionine Phyre2 PDB 3so4 chain C Region: 6 - 401 Aligned: 368 Modelled: 368 Confidence: 100.0% Identity: 52% PDB header:transferase Chain: C: PDB Molecule:methionine-adenosyltransferase; PDBTitle: methionine-adenosyltransferase from entamoeba histolytica Phyre2 PDB 3iml chain B Region: 6 - 403 Aligned: 356 Modelled: 356 Confidence: 100.0% Identity: 60% PDB header:transferase Chain: B: PDB Molecule:s-adenosylmethionine synthetase; PDBTitle: crystal structure of s-adenosylmethionine synthetase from burkholderia2 pseudomallei Phyre2 PDB 4le5 chain A Region: 6 - 403 Aligned: 368 Modelled: 368 Confidence: 100.0% Identity: 43% PDB header:transferase Chain: A: PDB Molecule:s-adenosylmethionine synthetase; PDBTitle: structure of an unusual s-adenosylmethionine synthetase from2 campylobacter jejuni Phyre2 PDB 1mxa chain A domain 3 Region: 253 - 403 Aligned: 149 Modelled: 151 Confidence: 100.0% Identity: 67% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 1qm4 chain A domain 3 Region: 253 - 397 Aligned: 143 Modelled: 145 Confidence: 100.0% Identity: 62% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 2p02 chain A domain 3 Region: 253 - 397 Aligned: 143 Modelled: 145 Confidence: 100.0% Identity: 61% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 1mxa chain A domain 2 Region: 125 - 252 Aligned: 123 Modelled: 128 Confidence: 100.0% Identity: 50% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 2p02 chain A domain 2 Region: 126 - 252 Aligned: 122 Modelled: 127 Confidence: 100.0% Identity: 45% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 1qm4 chain A domain 2 Region: 128 - 252 Aligned: 120 Modelled: 125 Confidence: 100.0% Identity: 49% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 2p02 chain A domain 1 Region: 5 - 116 Aligned: 109 Modelled: 112 Confidence: 100.0% Identity: 56% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 1mxa chain A domain 1 Region: 4 - 107 Aligned: 101 Modelled: 104 Confidence: 100.0% Identity: 60% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 1qm4 chain A domain 1 Region: 5 - 106 Aligned: 99 Modelled: 102 Confidence: 100.0% Identity: 56% Fold: S-adenosylmethionine synthetase Superfamily: S-adenosylmethionine synthetase Family: S-adenosylmethionine synthetase Phyre2 PDB 4hpv chain A Region: 11 - 359 Aligned: 314 Modelled: 308 Confidence: 99.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:s-adenosylmethionine synthase; PDBTitle: crystal structure of s-adenosylmethionine synthetase from sulfolobus2 solfataricus Phyre2 PDB 4l4q chain A Region: 11 - 359 Aligned: 320 Modelled: 320 Confidence: 99.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:s-adenosylmethionine synthase; PDBTitle: methionine adenosyltransferase Phyre2 PDB 2mbl chain A Region: 70 - 107 Aligned: 38 Modelled: 38 Confidence: 52.2% Identity: 21% PDB header:de novo protein Chain: A: PDB Molecule:top7 fold protein top7m13; PDBTitle: solution nmr structure of de novo designed top7 fold protein top7m13,2 northeast structural genomics consortium (nesg) target or33 Phyre2 1 c5h9uC_ 2 c1rg9D_ 3 c3rv2B_ 4 c2obvA_ 5 c4odjA_ 6 c3so4C_ 7 c3imlB_ 8 c4le5A_ 9 d1mxaa3 10 d1qm4a3 11 d2p02a3 12 d1mxaa2 13 d2p02a2 14 d1qm4a2 15 d2p02a1 16 d1mxaa1 17 d1qm4a1 18 c4hpvA_ 19 c4l4qA_ 20 c2mblA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99