1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	L	V	D	S	D	V	L	I	A	H	L	R	G	V	V	A	A	R	D	W	L	V	S	A	R	K	D	G	P	L	A	I	S	V	V	S	T	A	E	L	I	G	G	M	R	T	A	E	R	R	E	V	W	R	L	L	A	S
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	R	V	Q	P	A	T	E	V	I	A	R	R	A	G	D	M	M	R	R	Y	R	R	S	H	N	R	I	G	L	G	D	Y	L	I	A	A	T	A	D	V	Q	D	L	Q	L	A	T	L	N	V	W	H	F	P	M	F	E	Q	L
Secondary structure
SS confidence
Disorder																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.
Sequence		K	P	P	F	A	V	P	G	H	R	P	R	A
Secondary structure
SS confidence
Disorder								?		?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 6%) Alpha helix ( 55%) Beta strand ( 11%)

Rank Aligned region

PDB 6nkl chain A Region: 1 - 123 Aligned: 123 Modelled: 123 Confidence: 99.9% Identity: 24% PDB header:antitoxin Chain: A: PDB Molecule:ribonuclease vapc; PDBTitle: 2.2 a resolution structure of vapbc-1 from nontypeable haemophilus2 influenzae Phyre2 PDB 3tnd chain C Region: 2 - 122 Aligned: 120 Modelled: 121 Confidence: 99.9% Identity: 22% PDB header:translation, toxin Chain: C: PDB Molecule:trna(fmet)-specific endonuclease vapc; PDBTitle: crystal structure of shigella flexneri vapbc toxin-antitoxin complex Phyre2 PDB 3zvk chain C Region: 1 - 122 Aligned: 121 Modelled: 122 Confidence: 99.9% Identity: 19% PDB header:antitoxin/toxin/dna Chain: C: PDB Molecule:toxin of toxin-antitoxin system; PDBTitle: crystal structure of vapbc2 from rickettsia felis bound to2 a dna fragment from their promoter Phyre2 PDB 3h87 chain B Region: 2 - 132 Aligned: 126 Modelled: 131 Confidence: 99.9% Identity: 24% PDB header:toxin/antitoxin Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 2h1c chain A domain 1 Region: 1 - 129 Aligned: 126 Modelled: 129 Confidence: 99.9% Identity: 25% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v96 chain A domain 1 Region: 2 - 123 Aligned: 120 Modelled: 122 Confidence: 99.9% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 5l6m chain C Region: 2 - 123 Aligned: 118 Modelled: 122 Confidence: 99.9% Identity: 22% PDB header:hydrolase Chain: C: PDB Molecule:ribonuclease vapc; PDBTitle: structure of caulobacter crescentus vapbc1 (vapb1deltac:vapc1 form) Phyre2 PDB 5sv2 chain A Region: 2 - 128 Aligned: 124 Modelled: 127 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease vapc21; PDBTitle: toxin vapc21 from mycobacterium tuberculosis Phyre2 PDB 1y82 chain A domain 1 Region: 2 - 122 Aligned: 119 Modelled: 121 Confidence: 99.8% Identity: 20% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 4chg chain C Region: 2 - 123 Aligned: 121 Modelled: 121 Confidence: 99.8% Identity: 25% PDB header:toxin/antitoxin Chain: C: PDB Molecule:probable ribonuclease vapc15; PDBTitle: crystal structure of vapbc15 complex from mycobacterium tuberculosis Phyre2 PDB 3dbo chain B Region: 2 - 120 Aligned: 108 Modelled: 119 Confidence: 99.8% Identity: 27% PDB header:toxin/antitoxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a member of the vapbc family of toxin-antitoxin2 systems, vapbc-5, from mycobacterium tuberculosis Phyre2 PDB 4xgr chain G Region: 1 - 125 Aligned: 122 Modelled: 123 Confidence: 99.8% Identity: 16% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc30; PDBTitle: crystal structure of addiction module from mycobacterial species Phyre2 PDB 6a7v chain G Region: 2 - 126 Aligned: 124 Modelled: 125 Confidence: 99.8% Identity: 18% PDB header:toxin/antitoxin Chain: G: PDB Molecule:ribonuclease vapc11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 5x3t chain D Region: 2 - 126 Aligned: 123 Modelled: 124 Confidence: 99.7% Identity: 17% PDB header:antitoxin/toxin Chain: D: PDB Molecule:ribonuclease vapc26; PDBTitle: vapbc from mycobacterium tuberculosis Phyre2 PDB 5wzf chain B Region: 2 - 125 Aligned: 120 Modelled: 124 Confidence: 99.6% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:23s rrna-specific endonuclease vapc20; PDBTitle: crystal structure of mycobacterium tuberculosis vapc20 (rv2549c),2 sarcin-ricin loop cleaving toxin Phyre2 PDB 2fe1 chain A domain 1 Region: 2 - 120 Aligned: 114 Modelled: 119 Confidence: 99.5% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 2fe1 chain A Region: 2 - 120 Aligned: 114 Modelled: 119 Confidence: 99.5% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein pae0151; PDBTitle: crystal structure of pae0151 from pyrobaculum aerophilum Phyre2 PDB 3ix7 chain A Region: 2 - 131 Aligned: 111 Modelled: 116 Confidence: 98.4% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ttha0540; PDBTitle: crystal structure of a domain of functionally unknown protein from2 thermus thermophilus hb8 Phyre2 PDB 1w8i chain A Region: 2 - 115 Aligned: 112 Modelled: 114 Confidence: 98.3% Identity: 14% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 PDB 1v8p chain A Region: 2 - 119 Aligned: 107 Modelled: 118 Confidence: 98.2% Identity: 17% Fold: PIN domain-like Superfamily: PIN domain-like Family: PIN domain Phyre2 1 c6nklA_ 2 c3tndC_ 3 c3zvkC_ 4 c3h87B_ 5 d2h1ca1 6 d1v96a1 7 c5l6mC_ 8 c5sv2A_ 9 d1y82a1 10 c4chgC_ 11 c3dboB_ 12 c4xgrG_ 13 c6a7vG_ 14 c5x3tD_ 15 c5wzfB_ 16 d2fe1a1 17 c2fe1A_ 18 c3ix7A_ 19 d1w8ia_ 20 d1v8pa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54