1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	V	E	Q	V	K	S	I	D	E	A	M	G	L	A	I	E	H	S	Y	Q	V	K	G	T	T	Y	P	K	P	P	V	G	A	V	I	V	D	P	N	G	R	I	V	G	A	G	G	T	E	P	A	G	G	D	H	A	E	V
Secondary structure
SS confidence
Disorder		?	?	?																					?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	L	R	R	A	G	G	L	A	A	G	A	I	V	V	V	T	M	E	P	C	N	H	Y	G	K	T	P	P	C	V	N	A	L	I	E	A	R	V	G	T	V	V	Y	A	V	A	D	P	N	G	I	A	G	G	G	A	G	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	S	A	A	G	L	Q	V	R	S	G	V	L	A	E	Q	V	A	A	G	P	L	R	E	W	L	H	K	Q	R	T	G	L	P	H	V	T	W	K	Y	A	T	S	I	D	G	R	S	A	A	A	D	G	S	S	Q	W	I	S	S
Secondary structure
SS confidence
Disorder																																															?				?	?	?	?	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	A	A	R	L	D	L	H	R	R	R	A	I	A	D	A	I	L	V	G	T	G	T	V	L	A	D	D	P	A	L	T	A	R	L	A	D	G	S	L	A	P	Q	Q	P	L	R	V	V	V	G	K	R	D	I	P	P	E	A	R
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	L	N	D	E	A	R	T	M	M	I	R	T	H	E	P	M	E	V	L	R	A	L	S	D	R	T	D	V	L	L	E	G	G	P	T	L	A	G	A	F	L	R	A	G	A	I	N	R	I	L	A	Y	V	A	P	I	L	L	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.
Sequence		G	P	V	T	A	V	D	D	V	G	V	S	N	I	T	N	A	L	R	W	Q	F	D	S	V	E	K	V	G	P	D	L	L	L	S	L	V	A	R
Secondary structure
SS confidence
Disorder				?	?	?	?	?		?																														?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 27%) Beta strand ( 28%)

Rank Aligned region

PDB 2d5n chain B Region: 8 - 338 Aligned: 326 Modelled: 331 Confidence: 100.0% Identity: 41% PDB header:hydrolase, oxidoreductase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: crystal structure of a bifunctional deaminase and reductase2 involved in riboflavin biosynthesis Phyre2 PDB 3zpg chain A Region: 5 - 338 Aligned: 330 Modelled: 334 Confidence: 100.0% Identity: 39% PDB header:hydrolase Chain: A: PDB Molecule:ribd; PDBTitle: acinetobacter baumannii ribd, form 2 Phyre2 PDB 2hxv chain A Region: 5 - 338 Aligned: 324 Modelled: 331 Confidence: 100.0% Identity: 33% PDB header:biosynthetic protein Chain: A: PDB Molecule:diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5- PDBTitle: crystal structure of a diaminohydroxyphosphoribosylaminopyrimidine2 deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase (tm1828)3 from thermotoga maritima at 1.80 a resolution Phyre2 PDB 2o7p chain A Region: 7 - 338 Aligned: 318 Modelled: 332 Confidence: 100.0% Identity: 42% PDB header:hydrolase, oxidoreductase Chain: A: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: the crystal structure of ribd from escherichia coli in complex with2 the oxidised nadp+ cofactor in the active site of the reductase3 domain Phyre2 PDB 2b3z chain A domain 2 Region: 8 - 153 Aligned: 144 Modelled: 146 Confidence: 100.0% Identity: 45% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 2azn chain A domain 1 Region: 151 - 339 Aligned: 185 Modelled: 189 Confidence: 100.0% Identity: 32% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: RibD C-terminal domain-like Phyre2 PDB 2b3z chain A domain 1 Region: 154 - 338 Aligned: 182 Modelled: 185 Confidence: 100.0% Identity: 37% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: RibD C-terminal domain-like Phyre2 PDB 5xux chain C Region: 152 - 339 Aligned: 188 Modelled: 188 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: C: PDB Molecule:conserved protein; PDBTitle: crystal structure of rib7 from methanosarcina mazei Phyre2 PDB 4xt6 chain A Region: 146 - 338 Aligned: 187 Modelled: 193 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:rv2671; PDBTitle: crystal structure of rv2671 from mycobacterium tuberculosis in complex2 with the tetrahydropteridine ring of tetrahydrofolate (thf) Phyre2 PDB 2p4g chain A Region: 139 - 338 Aligned: 198 Modelled: 200 Confidence: 100.0% Identity: 19% PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a pyrimidine reductase-like protein (dip1392)2 from corynebacterium diphtheriae nctc at 2.30 a resolution Phyre2 PDB 2hxv chain A domain 1 Region: 154 - 338 Aligned: 177 Modelled: 182 Confidence: 100.0% Identity: 30% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: RibD C-terminal domain-like Phyre2 PDB 2hxv chain A domain 2 Region: 9 - 153 Aligned: 143 Modelled: 145 Confidence: 100.0% Identity: 38% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 4ha7 chain B Region: 139 - 339 Aligned: 186 Modelled: 201 Confidence: 100.0% Identity: 23% PDB header:oxidoreductase Chain: B: PDB Molecule:2,5-diamino-6-ribosylamino-4(3h)-pyrimidinone 5'-phosphate PDBTitle: structural insights into the reduction mechanism of saccharomyces2 cerevisia riboflavin biosynthesis reductase rib7 Phyre2 PDB 3jtw chain B Region: 156 - 338 Aligned: 162 Modelled: 183 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_805003.1)2 from pediococcus pentosaceus atcc 25745 at 1.90 a resolution Phyre2 PDB 2nx8 chain A Region: 1 - 154 Aligned: 144 Modelled: 154 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:trna-specific adenosine deaminase; PDBTitle: the crystal structure of the trna-specific adenosine deaminase from2 streptococcus pyogenes Phyre2 PDB 2xw7 chain A Region: 151 - 339 Aligned: 167 Modelled: 189 Confidence: 100.0% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of mycobacterium smegmatis putative reductase ms0308 Phyre2 PDB 2g84 chain A domain 1 Region: 9 - 147 Aligned: 130 Modelled: 139 Confidence: 100.0% Identity: 31% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 3kgy chain A Region: 149 - 338 Aligned: 181 Modelled: 190 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional deaminase-reductase domain protein; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_001636057.1)2 from chloroflexus aurantiacus j-10-fl at 1.50 a resolution Phyre2 PDB 1z3a chain A domain 1 Region: 9 - 153 Aligned: 135 Modelled: 145 Confidence: 100.0% Identity: 33% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 2gd9 chain A Region: 152 - 337 Aligned: 167 Modelled: 186 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein yyap; PDBTitle: crystal structure of a putative dihydrofolate reductase (bsu40760,2 yyap) from bacillus subtilis at 2.30 a resolution Phyre2 1 c2d5nB_ 2 c3zpgA_ 3 c2hxvA_ 4 c2o7pA_ 5 d2b3za2 6 d2azna1 7 d2b3za1 8 c5xuxC_ 9 c4xt6A_ 10 c2p4gA_ 11 d2hxva1 12 d2hxva2 13 c4ha7B_ 14 c3jtwB_ 15 c2nx8A_ 16 c2xw7A_ 17 d2g84a1 18 c3kgyA_ 19 d1z3aa1 20 c2gd9A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127