1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	A	G	R	R	V	A	I	S	A	G	S	L	A	V	L	L	G	A	L	D	T	Y	V	V	V	T	I	M	R	D	I	M	N	S	V	G	I	P	I	N	Q	L	H	R	I	T	W	I	V	T	M	Y	L	L	G	Y	I	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?																																?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	M	P	L	L	G	R	A	S	D	R	F	G	R	K	L	M	L	Q	V	S	L	A	G	F	I	I	G	S	V	V	T	A	L	A	G	H	F	G	D	F	H	M	L	I	A	G	R	T	I	Q	G	V	A	S	G	A	L	L	P
Secondary structure
SS confidence
Disorder																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	T	L	A	L	G	A	D	L	W	S	Q	R	N	R	A	G	V	L	G	G	I	G	A	A	Q	E	L	G	S	V	L	G	P	L	Y	G	I	F	I	V	W	L	L	H	D	W	R	D	V	F	W	I	N	V	P	L	T	A	I
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	M	V	M	I	H	F	S	L	P	S	H	D	R	S	T	E	P	E	R	V	D	L	V	G	G	L	L	L	A	L	A	L	G	L	A	V	I	G	L	Y	N	P	N	P	D	G	K	H	V	L	P	D	Y	G	A	P	L	L	V
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	A	L	V	A	A	V	A	F	F	G	W	E	R	F	A	R	T	R	L	I	D	P	A	G	V	H	F	R	P	F	L	S	A	L	G	A	S	V	A	A	G	A	A	L	M	V	T	L	V	D	V	E	L	F	G	Q	G	V	L
Secondary structure
SS confidence
Disorder																												?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	M	D	Q	A	Q	A	A	G	M	L	L	W	F	L	I	A	L	P	I	G	A	V	T	G	G	W	I	A	T	R	A	G	D	R	A	V	A	F	A	G	L	L	I	A	A	Y	G	Y	W	L	I	S	H	W	P	V	D	L	L
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	D	R	H	N	I	L	G	L	F	T	V	P	A	M	H	T	D	L	V	V	A	G	L	G	L	G	L	V	I	G	P	L	S	S	A	T	L	R	V	V	P	S	A	Q	H	G	I	A	S	A	A	V	V	V	A	R	M	T	G
Secondary structure
SS confidence
Disorder		?			?	?	?	?	?																															?			?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		M	L	I	G	V	A	A	L	S	A	W	G	L	Y	R	F	N	Q	I	L	A	G	L	S	A	A	I	P	P	N	A	S	L	L	E	R	A	A	A	I	G	A	R	Y	Q	Q	A	F	A	L	M	Y	G	E	I	F	T	I	T	A
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.
Sequence		I	V	C	V	F	G	A	V	L	G	L	L	I	S	G	R	K	E	H	A	D	E	P	E	V	Q	E	Q	P	T	L	A	P	Q	V	E	P	L
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 74%) Beta strand ( 0%) TM helix ( 54%) (View membrane topology prediction)

Rank Aligned region

PDB 1pw4 chain A Region: 2 - 507 Aligned: 410 Modelled: 423 Confidence: 100.0% Identity: 14% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 6h7d chain A Region: 1 - 507 Aligned: 445 Modelled: 452 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 5c65 chain A Region: 1 - 507 Aligned: 439 Modelled: 448 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 4ybq chain B Region: 7 - 507 Aligned: 442 Modelled: 448 Confidence: 100.0% Identity: 10% PDB header:transport protein/immune system Chain: B: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: rat glut5 with fv in the outward-open form Phyre2 PDB 4lds chain B Region: 7 - 499 Aligned: 421 Modelled: 429 Confidence: 100.0% Identity: 13% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 6e9o chain A Region: 2 - 499 Aligned: 391 Modelled: 409 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 4zp0 chain A Region: 1 - 492 Aligned: 389 Modelled: 406 Confidence: 100.0% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 4pyp chain A Region: 2 - 497 Aligned: 436 Modelled: 441 Confidence: 100.0% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: crystal structure of the human glucose transporter glut1 Phyre2 PDB 4gbz chain A Region: 2 - 507 Aligned: 465 Modelled: 477 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:d-xylose-proton symporter; PDBTitle: the structure of the mfs (major facilitator superfamily) proton:xylose2 symporter xyle bound to d-glucose Phyre2 PDB 3wdo chain A Region: 1 - 515 Aligned: 404 Modelled: 413 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 6gs7 chain A Region: 9 - 502 Aligned: 461 Modelled: 469 Confidence: 100.0% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4cl5 chain B Region: 2 - 503 Aligned: 451 Modelled: 454 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 4j05 chain A Region: 5 - 512 Aligned: 413 Modelled: 426 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 6ei3 chain A Region: 6 - 507 Aligned: 474 Modelled: 478 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:proton-dependent oligopeptide transporter family protein; PDBTitle: crystal structure of auto inhibited pot family peptide transporter Phyre2 PDB 6g9x chain B Region: 6 - 499 Aligned: 368 Modelled: 380 Confidence: 100.0% Identity: 18% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 3o7p chain A Region: 5 - 496 Aligned: 410 Modelled: 417 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4iky chain A Region: 9 - 502 Aligned: 451 Modelled: 458 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 4w6v chain A Region: 9 - 499 Aligned: 451 Modelled: 458 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 6exs chain A Region: 9 - 499 Aligned: 448 Modelled: 455 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 4aps chain B Region: 9 - 493 Aligned: 433 Modelled: 446 Confidence: 100.0% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 1 d1pw4a_ 2 c6h7dA_ 3 c5c65A_ 4 c4ybqB_ 5 c4ldsB_ 6 c6e9oA_ 7 c4zp0A_ 8 c4pypA_ 9 c4gbzA_ 10 c3wdoA_ 11 c6gs7A_ 12 c4cl5B_ 13 c4j05A_ 14 c6ei3A_ 15 c6g9xB_ 16 c3o7pA_ 17 c4ikyA_ 18 c4w6vA_ 19 c6exsA_ 20 c4apsB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44