1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	C	L	G	R	P	G	C	R	G	W	A	G	A	S	L	V	L	V	V	V	L	A	L	A	A	C	T	E	S	V	A	G	R	A	M	R	A	T	D	R	S	S	G	L	P	T	S	A	K	P	A	R	A	R	D	L	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																						?	?		?		?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	D	G	D	R	A	P	F	G	Q	V	T	Q	S	R	V	G	D	S	Y	F	T	S	A	V	P	P	E	C	S	A	A	L	L	F	K	G	S	P	L	R	P	D	G	S	S	D	H	A	E	A	A	Y	N	V	T	G	P	L	P
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	A	E	S	V	D	V	Y	T	N	V	L	N	V	H	D	V	V	W	N	G	F	R	D	V	S	H	C	R	G	D	A	V	G	V	S	R	A	G	R	S	T	P	M	R	L	R	Y	F	A	T	L	S	D	G	V	L	V	W	T
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.
Sequence		M	S	N	P	R	W	T	C	D	Y	G	L	A	V	V	P	H	A	V	L	V	L	S	A	C	G	F	K	P	G	F	P	M	A	E	W	A	S	K	R	R	A	Q	L	D	S	Q	V
Secondary structure
SS confidence
Disorder																																											?			?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 48%) Beta strand ( 12%)

Rank Aligned region

PDB 4esq chain A Region: 86 - 227 Aligned: 141 Modelled: 142 Confidence: 72.6% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:serine/threonine protein kinase; PDBTitle: crystal structure of the extracellular domain of pknh from2 mycobacterium tuberculosis Phyre2 PDB 4b9c chain A Region: 164 - 190 Aligned: 22 Modelled: 27 Confidence: 14.0% Identity: 23% PDB header:carbohydrate-binding protein Chain: A: PDB Molecule:type 3a cellulose-binding domain protein; PDBTitle: biomass sensoring modules from putative rsgi-like proteins2 of clostridium thermocellum resemble family 3 carbohydrate-3 binding module of cellulosome Phyre2 PDB 1d1d chain A domain 1 Region: 43 - 64 Aligned: 22 Modelled: 22 Confidence: 13.8% Identity: 32% Fold: Acyl carrier protein-like Superfamily: Retrovirus capsid dimerization domain-like Family: Retrovirus capsid protein C-terminal domain Phyre2 PDB 5n60 chain Q Region: 179 - 191 Aligned: 13 Modelled: 13 Confidence: 12.5% Identity: 46% PDB header:transferase Chain: Q: PDB Molecule:rna polymerase i-specific transcription initiation factor PDBTitle: cryo-em structure of rna polymerase i in complex with rrn3 and core2 factor (orientation i) Phyre2 PDB 5dud chain B Region: 204 - 213 Aligned: 10 Modelled: 10 Confidence: 12.3% Identity: 60% PDB header:unknown function Chain: B: PDB Molecule:ybgj; PDBTitle: crystal structure of e. coli ybgjk Phyre2 PDB 6dex chain B Region: 160 - 183 Aligned: 24 Modelled: 24 Confidence: 11.4% Identity: 25% PDB header:recombination Chain: B: PDB Molecule:suppressor of hydroxyurea sensitivity protein 2; PDBTitle: structure of eremothecium gossypii shu1:shu2 complex Phyre2 PDB 4e6n chain B Region: 48 - 141 Aligned: 89 Modelled: 94 Confidence: 11.4% Identity: 18% PDB header:protein binding Chain: B: PDB Molecule:methyltransferase type 12; PDBTitle: crystal structure of bacterial pnkp-c/hen1-n heterodimer Phyre2 PDB 2zp2 chain B Region: 203 - 213 Aligned: 11 Modelled: 11 Confidence: 10.3% Identity: 55% PDB header:transferase inhibitor Chain: B: PDB Molecule:kinase a inhibitor; PDBTitle: c-terminal domain of kipi from bacillus subtilis Phyre2 PDB 3pnt chain A Region: 4 - 14 Aligned: 11 Modelled: 11 Confidence: 10.2% Identity: 55% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:nad+-glycohydrolase; PDBTitle: crystal structure of the streptococcus pyogenes nad+ glycohydrolase2 spn in complex with ifs, the immunity factor for spn Phyre2 PDB 3sum chain A Region: 202 - 210 Aligned: 9 Modelled: 9 Confidence: 9.9% Identity: 33% PDB header:unknown function Chain: A: PDB Molecule:cerato-platanin-like protein; PDBTitle: crystal structure of cerato-platanin 5 from m. perniciosa (mpcp5) Phyre2 PDB 1iyc chain A Region: 138 - 142 Aligned: 5 Modelled: 5 Confidence: 9.8% Identity: 100% Fold: Invertebrate chitin-binding proteins Superfamily: Invertebrate chitin-binding proteins Family: Antifungal peptide scarabaecin Phyre2 PDB 3mml chain D Region: 204 - 213 Aligned: 10 Modelled: 10 Confidence: 9.5% Identity: 60% PDB header:hydrolase Chain: D: PDB Molecule:allophanate hydrolase subunit 1; PDBTitle: allophanate hydrolase complex from mycobacterium smegmatis, msmeg0435-2 msmeg0436 Phyre2 PDB 6nd1 chain D Region: 191 - 205 Aligned: 15 Modelled: 15 Confidence: 8.7% Identity: 47% PDB header:protein transport Chain: D: PDB Molecule:protein transport protein sbh1; PDBTitle: cryoem structure of the sec complex from yeast Phyre2 PDB 1vl6 chain C Region: 153 - 210 Aligned: 53 Modelled: 58 Confidence: 8.4% Identity: 26% PDB header:oxidoreductase Chain: C: PDB Molecule:malate oxidoreductase; PDBTitle: crystal structure of nad-dependent malic enzyme (tm0542) from2 thermotoga maritima at 2.61 a resolution Phyre2 PDB 1vl6 chain A domain 1 Region: 153 - 210 Aligned: 53 Modelled: 58 Confidence: 8.3% Identity: 26% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Aminoacid dehydrogenase-like, C-terminal domain Phyre2 PDB 3dgs chain A Region: 136 - 150 Aligned: 15 Modelled: 15 Confidence: 8.2% Identity: 60% PDB header:viral protein Chain: A: PDB Molecule:coat protein a; PDBTitle: changing the determinants of protein stability from covalent to non-2 covalent interactions by in-vitro evolution: a structural and3 energetic analysis Phyre2 PDB 4b9p chain A Region: 164 - 190 Aligned: 21 Modelled: 27 Confidence: 8.2% Identity: 43% PDB header:carbohydrate-binding protein Chain: A: PDB Molecule:type 3a cellulose-binding domain protein; PDBTitle: biomass sensoring module from putative rsgi2 protein of2 clostridium thermocellum resemble family 3 carbohydrate-3 binding module of cellulosome Phyre2 PDB 2ylk chain D Region: 164 - 190 Aligned: 21 Modelled: 27 Confidence: 7.7% Identity: 33% PDB header:hydrolase Chain: D: PDB Molecule:cellulose 1,4-beta-cellobiosidase; PDBTitle: carbohydrate-binding module cbm3b from the cellulosomal2 cellobiohydrolase 9a from clostridium thermocellum Phyre2 PDB 2kk4 chain A Region: 113 - 134 Aligned: 22 Modelled: 22 Confidence: 7.7% Identity: 41% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein af_2094; PDBTitle: solution nmr structure of protein af2094 from archaeoglobus2 fulgidus. northeast structural genomics consotium (nesg)3 target gt2 Phyre2 PDB 2vrd chain A domain 1 Region: 184 - 190 Aligned: 7 Modelled: 7 Confidence: 7.6% Identity: 57% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: HkH motif-containing C2H2 finger Phyre2 1 c4esqA_ 2 c4b9cA_ 3 d1d1da1 4 c5n60Q_ 5 c5dudB_ 6 c6dexB_ 7 c4e6nB_ 8 c2zp2B_ 9 c3pntA_ 10 c3sumA_ 11 d1iyca_ 12 c3mmlD_ 13 c6nd1D_ 14 c1vl6C_ 15 d1vl6a1 16 c3dgsA_ 17 c4b9pA_ 18 c2ylkD_ 19 c2kk4A_ 20 d2vrda1 21 22 23 24 25 26 27 28 29 30