1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	D	P	A	T	Y	R	P	A	P	G	S	I	P	V	E	P	G	V	Y	R	F	R	D	Q	H	G	R	V	I	Y	V	G	K	A	K	S	L	R	S	R	L	T	S	Y	F	A	D	V	A	S	L	A	P	R	T	R	Q	L
Secondary structure
SS confidence
Disorder		?	?	?																																			?											?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	T	T	A	A	K	V	E	W	T	V	V	G	T	E	V	E	A	L	Q	L	E	Y	T	W	I	K	E	F	D	P	R	F	N	V	R	Y	R	D	D	K	S	Y	P	V	L	A	V	T	L	G	E	E	F	P	R	L	M	V	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	G	P	R	R	K	G	V	R	Y	F	G	P	Y	S	H	A	W	A	I	R	E	T	L	D	L	L	T	R	V	F	P	A	R	T	C	S	A	G	V	F	K	R	H	R	Q	I	D	R	P	C	L	L	G	Y	I	D	K	C	S
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	P	C	I	G	R	V	D	A	A	Q	H	R	Q	I	V	A	D	F	C	D	F	L	S	G	K	T	D	R	F	A	R	A	L	E	Q	Q	M	N	A	A	A	E	Q	L	D	F	E	R	A	A	R	L	R	D	D	L	S	A	L
Secondary structure
SS confidence
Disorder																																														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		K	R	A	M	E	K	Q	A	V	V	L	G	D	G	T	D	A	D	V	V	A	F	A	D	D	E	L	E	A	A	V	Q	V	F	H	V	R	G	G	R	V	R	G	Q	R	G	W	I	V	E	K	P	G	E	P	G	D	S	G	I
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?																																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	L	V	E	Q	F	L	T	Q	F	Y	G	D	Q	A	A	L	D	D	A	A	D	E	S	A	N	P	V	P	R	E	V	L	V	P	C	L	P	S	N	A	E	E	L	A	S	W	L	S	G	L	R	G	S	R	V	V	L	R	V
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?	?														?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	R	R	G	D	K	R	A	L	A	E	T	V	H	R	N	A	E	D	A	L	Q	Q	H	K	L	K	R	A	S	D	F	N	A	R	S	A	A	L	Q	S	I	Q	D	S	L	G	L	A	D	A	P	L	R	I	E	C	V	D	V
Secondary structure
SS confidence
Disorder																															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		S	H	V	Q	G	T	D	V	V	G	S	L	V	V	F	E	D	G	L	P	R	K	S	D	Y	R	H	F	G	I	R	E	A	A	G	Q	G	R	S	D	D	V	A	C	I	A	E	V	T	R	R	R	F	L	R	H	L	R	D	Q
Secondary structure
SS confidence
Disorder																					?	?	?	?										?	?	?	?	?	?	?	?																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		S	D	P	D	L	L	S	P	E	R	K	S	R	R	F	A	Y	P	P	N	L	Y	V	V	D	G	G	A	P	Q	V	N	A	A	S	A	V	I	D	E	L	G	V	T	D	V	A	V	I	G	L	A	K	R	L	E	E	V	W	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		P	S	E	P	D	P	I	I	M	P	R	N	S	E	G	L	Y	L	L	Q	R	V	R	D	E	A	H	R	F	A	I	T	Y	H	R	S	K	R	S	T	R	M	T	A	S	A	L	D	S	V	P	G	L	G	E	H	R	R	K	A
Secondary structure
SS confidence
Disorder											?																										?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.
Sequence		L	V	T	H	F	G	S	I	A	R	L	K	E	A	T	V	D	E	I	T	A	V	P	G	I	G	V	A	T	A	T	A	V	H	D	A	L	R	P	D	S	S	G	A	A	R
Secondary structure
SS confidence
Disorder																										?														?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 44%) Beta strand ( 17%)

Rank Aligned region

PDB 2nrz chain B Region: 395 - 637 Aligned: 210 Modelled: 223 Confidence: 100.0% Identity: 46% PDB header:hydrolase Chain: B: PDB Molecule:uvrabc system protein c; PDBTitle: crystal structure of the c-terminal half of uvrc bound to its2 catalytic divalent cation Phyre2 PDB 3c65 chain A Region: 399 - 571 Aligned: 150 Modelled: 155 Confidence: 100.0% Identity: 42% PDB header:hydrolase Chain: A: PDB Molecule:uvrabc system protein c; PDBTitle: crystal structure of bacillus stearothermophilus uvrc 5' endonuclease2 domain Phyre2 PDB 2nrr chain A Region: 398 - 573 Aligned: 137 Modelled: 156 Confidence: 100.0% Identity: 50% PDB header:hydrolase Chain: A: PDB Molecule:uvrabc system protein c; PDBTitle: crystal structure of the c-terminal rnaseh endonuclase domain of uvrc Phyre2 PDB 1yd2 chain A Region: 5 - 96 Aligned: 88 Modelled: 92 Confidence: 99.9% Identity: 39% PDB header:dna binding protein Chain: A: PDB Molecule:uvrabc system protein c; PDBTitle: crystal structure of the giy-yig n-terminal endonuclease domain of2 uvrc from thermotoga maritima: point mutant y19f bound to the3 catalytic divalent cation Phyre2 PDB 2wsh chain C Region: 14 - 95 Aligned: 82 Modelled: 82 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: C: PDB Molecule:endonuclease ii; PDBTitle: structure of bacteriophage t4 endoii e118a mutant Phyre2 PDB 1yd6 chain A Region: 5 - 99 Aligned: 93 Modelled: 95 Confidence: 99.9% Identity: 42% PDB header:dna binding protein Chain: A: PDB Molecule:uvrc; PDBTitle: crystal structure of the giy-yig n-terminal endonuclease2 domain of uvrc from bacillus caldotenax Phyre2 PDB 1kft chain A Region: 584 - 638 Aligned: 55 Modelled: 55 Confidence: 99.4% Identity: 35% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Excinuclease UvrC C-terminal domain Phyre2 PDB 1kft chain A Region: 584 - 638 Aligned: 55 Modelled: 55 Confidence: 99.4% Identity: 35% PDB header:dna binding protein Chain: A: PDB Molecule:excinuclease abc subunit c; PDBTitle: solution structure of the c-terminal domain of uvrc from e-2 coli Phyre2 PDB 1x2i chain A domain 1 Region: 580 - 640 Aligned: 61 Modelled: 61 Confidence: 99.3% Identity: 25% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 2lyh chain A Region: 578 - 639 Aligned: 60 Modelled: 62 Confidence: 99.3% Identity: 27% PDB header:dna binding protein Chain: A: PDB Molecule:fanconi anemia-associated protein of 24 kda; PDBTitle: structure of faap24 residues 141-215 Phyre2 PDB 2aq0 chain A domain 1 Region: 584 - 643 Aligned: 59 Modelled: 60 Confidence: 99.3% Identity: 25% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 2bgw chain A domain 1 Region: 578 - 640 Aligned: 63 Modelled: 63 Confidence: 99.3% Identity: 29% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 2a1j chain B domain 1 Region: 570 - 640 Aligned: 71 Modelled: 71 Confidence: 99.3% Identity: 21% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 2mut chain A Region: 570 - 640 Aligned: 71 Modelled: 71 Confidence: 99.2% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:dna excision repair protein ercc-1; PDBTitle: solution structure of the f231l mutant ercc1-xpf dimerization region Phyre2 PDB 4bxo chain B Region: 471 - 639 Aligned: 132 Modelled: 135 Confidence: 99.1% Identity: 20% PDB header:hydrolase/dna Chain: B: PDB Molecule:fanconi anemia-associated protein of 24 kda; PDBTitle: architecture and dna recognition elements of the fanconi anemia fancm-2 faap24 complex Phyre2 PDB 2i1q chain A domain 1 Region: 587 - 639 Aligned: 53 Modelled: 53 Confidence: 99.0% Identity: 28% Fold: SAM domain-like Superfamily: Rad51 N-terminal domain-like Family: DNA repair protein Rad51, N-terminal domain Phyre2 PDB 4bxo chain A Region: 578 - 642 Aligned: 65 Modelled: 65 Confidence: 99.0% Identity: 12% PDB header:hydrolase/dna Chain: A: PDB Molecule:fanconi anemia group m protein; PDBTitle: architecture and dna recognition elements of the fanconi anemia fancm-2 faap24 complex Phyre2 PDB 1pzn chain A domain 1 Region: 587 - 642 Aligned: 56 Modelled: 56 Confidence: 98.9% Identity: 23% Fold: SAM domain-like Superfamily: Rad51 N-terminal domain-like Family: DNA repair protein Rad51, N-terminal domain Phyre2 PDB 1mk0 chain A Region: 17 - 103 Aligned: 87 Modelled: 87 Confidence: 98.9% Identity: 22% Fold: GIY-YIG endonuclease Superfamily: GIY-YIG endonuclease Family: GIY-YIG endonuclease Phyre2 PDB 2bhn chain D Region: 580 - 640 Aligned: 61 Modelled: 61 Confidence: 98.8% Identity: 30% PDB header:hydrolase Chain: D: PDB Molecule:xpf endonuclease; PDBTitle: xpf from aeropyrum pernix Phyre2 1 c2nrzB_ 2 c3c65A_ 3 c2nrrA_ 4 c1yd2A_ 5 c2wshC_ 6 c1yd6A_ 7 d1kfta_ 8 c1kftA_ 9 d1x2ia1 10 c2lyhA_ 11 d2aq0a1 12 d2bgwa1 13 d2a1jb1 14 c2mutA_ 15 c4bxoB_ 16 d2i1qa1 17 c4bxoA_ 18 d1pzna1 19 d1mk0a_ 20 c2bhnD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293