1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	F	V	F	A	V	P	E	M	V	A	A	T	A	S	D	L	A	S	L	G	A	A	L	S	E	A	T	A	A	A	A	I	P	T	T	Q	V	L	A	A	A	A	D	E	V	S	A	A	I	A	E	L	F	G	A	H	G	Q
Secondary structure
SS confidence
Disorder		?	?	?			?	?	?																						?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	F	Q	A	L	S	A	Q	A	S	A	F	H	D	R	F	V	R	A	L	S	A	A	A	G	W	Y	V	D	A	E	A	A	N	A	A	L	V	D	T	A	A	T	G	A	S	E	L	G	S	G	G	R	T	A	L	I	L	G	S
Secondary structure
SS confidence
Disorder																										?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	G	T	P	R	P	P	F	D	Y	M	Q	Q	V	Y	D	R	Y	I	A	P	H	Y	L	G	Y	A	F	S	G	L	Y	T	P	A	Q	F	Q	P	W	T	G	I	P	S	L	T	Y	D	Q	S	V	A	E	G	A	G	Y	L	H
Secondary structure
SS confidence
Disorder		?	?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	A	I	M	Q	Q	V	A	A	G	N	D	V	V	V	L	G	F	S	Q	G	A	S	V	A	T	L	E	M	R	H	L	A	S	L	P	A	G	V	A	P	S	P	D	Q	L	S	F	V	L	L	G	N	P	N	N	P	N	G	G
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	L	A	R	F	P	G	L	Y	L	Q	S	L	G	L	T	F	N	G	A	T	P	D	T	D	Y	A	T	T	I	Y	T	T	Q	Y	D	G	F	A	D	F	P	K	Y	P	L	N	I	L	A	D	V	N	A	L	L	G	I	Y	Y
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	H	S	L	Y	Y	G	L	T	P	E	Q	V	A	S	G	I	V	L	P	V	S	S	P	D	T	N	T	T	Y	I	L	L	P	N	E	D	L	P	L	L	Q	P	L	R	G	I	V	P	E	P	L	L	D	L	I	E	P	D	L
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	A	I	I	E	L	G	Y	D	R	T	G	Y	A	D	V	P	T	P	A	A	L	F	P	V	H	I	D	P	I	A	V	P	P	Q	I	G	A	A	I	G	G	P	L	T	A	L	D	G	L	L	D	T	V	I	N	D	Q	L	N
Secondary structure
SS confidence
Disorder																														?	?	?	?																						?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	V	V	T	S	G	I	Y	Q	A	G	A	E	L	S	V	A	A	A	G	Y	G	A	P	A	G	V	T	N	A	I	F	I	G	Q	Q	V	L	P	I	L	V	E	G	P	G	A	L	V	T	A	D	T	H	Y	L	V	D	A	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.
Sequence		Q	D	L	A	A	G	D	L	S	G	F	N	Q	N	L	Q	L	I	P	A	T	N	I	A	L	L	V	F	A	A	G	I	P	A	V	A	A	V	A	I	L	T	G	Q	D	F	P	V
Secondary structure
SS confidence
Disorder				?	?																																						?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 47%) Beta strand ( 8%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 5xfs chain A Region: 7 - 84 Aligned: 78 Modelled: 78 Confidence: 99.9% Identity: 50% PDB header:protein transport Chain: A: PDB Molecule:pe family protein pe8; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 2g38 chain A domain 1 Region: 8 - 84 Aligned: 77 Modelled: 77 Confidence: 99.9% Identity: 26% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PE Phyre2 PDB 2g38 chain A Region: 8 - 84 Aligned: 77 Modelled: 77 Confidence: 99.9% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 3aja chain A Region: 111 - 323 Aligned: 208 Modelled: 213 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of msmeg_6394 Phyre2 PDB 1qoz chain A Region: 111 - 305 Aligned: 177 Modelled: 181 Confidence: 99.4% Identity: 18% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 1g66 chain A Region: 111 - 305 Aligned: 177 Modelled: 181 Confidence: 99.4% Identity: 18% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 3hc7 chain A Region: 114 - 296 Aligned: 171 Modelled: 183 Confidence: 99.3% Identity: 20% PDB header:cell adhesion Chain: A: PDB Molecule:gene 12 protein; PDBTitle: crystal structure of lysin b from mycobacteriophage d29 Phyre2 PDB 2czq chain B Region: 105 - 305 Aligned: 175 Modelled: 190 Confidence: 99.2% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:cutinase-like protein; PDBTitle: a novel cutinase-like protein from cryptococcus sp. Phyre2 PDB 3dd5 chain F Region: 96 - 249 Aligned: 144 Modelled: 152 Confidence: 99.1% Identity: 14% PDB header:hydrolase Chain: F: PDB Molecule:cutinase; PDBTitle: glomerella cingulata e600-cutinase complex Phyre2 PDB 1cex chain A Region: 98 - 249 Aligned: 140 Modelled: 152 Confidence: 99.0% Identity: 12% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 5x88 chain A Region: 111 - 249 Aligned: 127 Modelled: 137 Confidence: 99.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:cutinase; PDBTitle: a crystal structure of cutinases from malbranchea cinnamomea Phyre2 PDB 4oyl chain C Region: 97 - 240 Aligned: 135 Modelled: 144 Confidence: 98.9% Identity: 13% PDB header:hydrolase Chain: C: PDB Molecule:cutinase; PDBTitle: humicola insolens cutinase in complex with mono-ethylphosphate Phyre2 PDB 3gbs chain A Region: 111 - 237 Aligned: 119 Modelled: 127 Confidence: 98.7% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:cutinase 1; PDBTitle: crystal structure of aspergillus oryzae cutinase Phyre2 PDB 4psd chain A Region: 71 - 236 Aligned: 153 Modelled: 166 Confidence: 98.7% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:carbohydrate esterase family 5; PDBTitle: structure of trichoderma reesei cutinase native form. Phyre2 PDB 1mo2 chain A Region: 74 - 234 Aligned: 138 Modelled: 153 Confidence: 95.5% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:erythronolide synthase, modules 5 and 6; PDBTitle: thioesterase domain from 6-deoxyerythronolide synthase (debs te), ph2 8.5 Phyre2 PDB 1mo2 chain A Region: 74 - 234 Aligned: 138 Modelled: 153 Confidence: 95.5% Identity: 15% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Thioesterase domain of polypeptide, polyketide and fatty acid synthases Phyre2 PDB 3icv chain A Region: 172 - 279 Aligned: 101 Modelled: 108 Confidence: 95.4% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:lipase b; PDBTitle: structural consequences of a circular permutation on lipase b from2 candida antartica Phyre2 PDB 1tca chain A Region: 171 - 236 Aligned: 60 Modelled: 60 Confidence: 94.5% Identity: 23% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Fungal lipases Phyre2 PDB 5xav chain B Region: 164 - 234 Aligned: 65 Modelled: 71 Confidence: 94.4% Identity: 14% PDB header:biosynthetic protein Chain: B: PDB Molecule:intracellular polyhydroxyalkanoate synthase; PDBTitle: structure of phac from chromobacterium sp. usm2 Phyre2 PDB 5xfs chain B Region: 8 - 72 Aligned: 61 Modelled: 65 Confidence: 94.4% Identity: 21% PDB header:protein transport Chain: B: PDB Molecule:ppe family protein ppe15; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 1 c5xfsA_ 2 d2g38a1 3 c2g38A_ 4 c3ajaA_ 5 d1qoza_ 6 d1g66a_ 7 c3hc7A_ 8 c2czqB_ 9 c3dd5F_ 10 d1cexa_ 11 c5x88A_ 12 c4oylC_ 13 c3gbsA_ 14 c4psdA_ 15 c1mo2A_ 16 d1mo2a_ 17 c3icvA_ 18 d1tcaa_ 19 c5xavB_ 20 c5xfsB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141