1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	F	L	K	P	D	L	P	D	V	D	H	D	T	W	L	T	Q	P	R	R	T	R	L	Q	V	V	T	R	D	W	V	E	H	G	F	G	T	P	Y	A	V	Y	L	L	Y	L	T	K	I	A	V	Y	V	A	A	G	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?										?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	I	S	L	N	P	G	L	G	G	L	S	R	I	G	D	W	W	T	Q	P	I	V	Y	Q	K	V	I	V	F	T	L	L	F	E	V	L	G	F	G	C	G	S	G	P	L	T	G	R	F	W	P	P	I	G	G	F	L	Y	W
Secondary structure
SS confidence
Disorder							?		?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	R	P	N	T	I	R	L	P	A	W	P	D	K	V	P	F	T	Q	G	D	T	R	T	V	V	D	V	A	L	Y	A	I	V	L	I	G	G	V	W	A	L	L	S	P	G	S	P	G	P	G	G	T	P	V	T	A	A	G	D
Secondary structure
SS confidence
Disorder																			?																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	G	L	I	N	P	V	L	V	V	P	T	I	V	A	L	G	V	L	G	L	R	D	K	T	I	F	L	A	A	R	G	E	H	Y	W	L	K	L	F	V	F	F	F	P	F	T	D	Q	I	A	A	F	K	I	I	M	L	C	L
Secondary structure
SS confidence
Disorder		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		W	W	G	A	A	T	S	K	L	N	H	H	F	P	Y	V	V	A	V	M	T	S	N	N	A	L	L	R	S	R	V	F	N	P	I	K	H	L	L	Y	R	D	H	A	N	D	L	R	P	S	W	L	P	K	L	M	A	H	G	G
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	T	T	A	E	F	L	V	P	G	I	L	V	L	V	A	D	G	H	P	W	R	W	F	L	I	G	F	M	V	L	F	H	L	N	I	L	S	N	L	P	M	G	V	P	L	E	W	N	V	F	F	I	F	S	L	C	Y	L	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	H	Y	G	A	I	T	A	T	D	L	R	S	P	L	L	L	A	I	V	I	A	V	V	A	V	V	I	M	G	N	L	L	P	E	K	I	S	F	L	P	A	M	R	Y	Y	A	G	N	W	A	T	S	I	W	C	F	R	G	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	E	A	T	M	E	T	S	V	V	K	S	S	A	L	V	V	N	Q	L	A	K	L	Y	D	G	A	T	A	E	I	M	T	D	K	V	A	A	F	R	A	M	H	T	H	G	R	A	L	N	G	L	L	P	R	A	L	D	D	E
Secondary structure
SS confidence
Disorder													?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	H	Y	R	I	R	E	G	E	I	V	A	G	P	L	V	G	W	N	F	G	E	G	H	L	H	N	E	Q	L	V	A	A	V	Q	R	R	C	N	F	A	D	G	D	L	R	V	I	I	L	E	G	Q	P	I	H	V	Q	K	Q
Secondary structure
SS confidence
Disorder													?																											?														?	?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.
Sequence		W	Y	R	I	V	D	A	K	T	G	L	F	E	A	G	Y	V	T	V	E	D	M	L	S	R	Q	P	W	P	E	P	G	D	E	F	P	V	H	V	T	T	Q	R	G	T	P	S	K	P
Secondary structure
SS confidence
Disorder																								?	?	?	?	?		?	?	?											?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 61%) Beta strand ( 5%) TM helix ( 32%) (View membrane topology prediction)

Rank Aligned region

PDB 2r6g chain F domain 1 Region: 499 - 568 Aligned: 66 Modelled: 70 Confidence: 58.5% Identity: 12% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 1fo1 chain A domain 2 Region: 508 - 525 Aligned: 17 Modelled: 18 Confidence: 40.0% Identity: 24% Fold: Ferredoxin-like Superfamily: RNA-binding domain, RBD Family: Non-canonical RBD domain Phyre2 PDB 3hi2 chain C Region: 441 - 461 Aligned: 21 Modelled: 21 Confidence: 35.9% Identity: 24% PDB header:dna binding protein/toxin Chain: C: PDB Molecule:hth-type transcriptional regulator mqsa(ygit); PDBTitle: structure of the n-terminal domain of the e. coli antitoxin mqsa2 (ygit/b3021) in complex with the e. coli toxin mqsr (ygiu/b3022) Phyre2 PDB 3lzk chain C Region: 508 - 579 Aligned: 66 Modelled: 71 Confidence: 34.3% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:fumarylacetoacetate hydrolase family protein; PDBTitle: the crystal structure of a probably aromatic amino acid2 degradation protein from sinorhizobium meliloti 1021 Phyre2 PDB 2l6p chain A Region: 478 - 504 Aligned: 27 Modelled: 27 Confidence: 32.6% Identity: 15% PDB header:structure genomics, unknown function Chain: A: PDB Molecule:phac1, phac2 and phad genes; PDBTitle: nmr solution structure of the protein np_253742.1 Phyre2 PDB 1kpt chain A Region: 463 - 532 Aligned: 70 Modelled: 70 Confidence: 32.1% Identity: 16% Fold: Yeast killer toxins Superfamily: Yeast killer toxins Family: Virally encoded KP4 toxin Phyre2 PDB 1b4r chain A Region: 498 - 503 Aligned: 6 Modelled: 6 Confidence: 28.8% Identity: 67% Fold: Immunoglobulin-like beta-sandwich Superfamily: PKD domain Family: PKD domain Phyre2 PDB 2hjj chain A Region: 414 - 429 Aligned: 16 Modelled: 16 Confidence: 28.1% Identity: 25% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ykff; PDBTitle: solution nmr structure of protein ykff from escherichia coli.2 northeast structural genomics target er397. Phyre2 PDB 2hjj chain A domain 1 Region: 414 - 429 Aligned: 16 Modelled: 16 Confidence: 28.1% Identity: 25% Fold: dsRBD-like Superfamily: YcfA/nrd intein domain Family: YkfF-like Phyre2 PDB 5jpq chain I Region: 269 - 288 Aligned: 20 Modelled: 20 Confidence: 25.9% Identity: 20% PDB header:ribosome Chain: I: PDB Molecule:u3 small nucleolar rna-associated protein 21; PDBTitle: cryo-em structure of the 90s pre-ribosome Phyre2 PDB 2l6n chain A Region: 478 - 504 Aligned: 27 Modelled: 27 Confidence: 24.2% Identity: 22% PDB header:structure genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein yp_001092504.1; PDBTitle: nmr solution structure of the protein yp_001092504.1 Phyre2 PDB 2ifo chain A Region: 270 - 279 Aligned: 10 Modelled: 10 Confidence: 24.1% Identity: 10% PDB header:virus Chain: A: PDB Molecule:inovirus; PDBTitle: model-building studies of inovirus: genetic variations on a2 geometric theme Phyre2 PDB 1tis chain A Region: 435 - 571 Aligned: 120 Modelled: 120 Confidence: 22.7% Identity: 18% Fold: Thymidylate synthase/dCMP hydroxymethylase Superfamily: Thymidylate synthase/dCMP hydroxymethylase Family: Thymidylate synthase/dCMP hydroxymethylase Phyre2 PDB 2zpa chain B Region: 252 - 288 Aligned: 37 Modelled: 37 Confidence: 22.3% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:uncharacterized protein ypfi; PDBTitle: crystal structure of trna(met) cytidine acetyltransferase Phyre2 PDB 2xu9 chain A Region: 517 - 589 Aligned: 71 Modelled: 73 Confidence: 22.2% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:laccase; PDBTitle: crystal structure of laccase from thermus thermophilus hb27 Phyre2 PDB 1wgo chain A Region: 498 - 503 Aligned: 6 Modelled: 6 Confidence: 21.6% Identity: 33% Fold: Immunoglobulin-like beta-sandwich Superfamily: PKD domain Family: PKD domain Phyre2 PDB 3iyn chain R Region: 125 - 133 Aligned: 9 Modelled: 9 Confidence: 20.4% Identity: 44% PDB header:virus Chain: R: PDB Molecule:hexon-associated protein; PDBTitle: 3.6-angstrom cryoem structure of human adenovirus type 5 Phyre2 PDB 6rdf chain 7 Region: 276 - 288 Aligned: 13 Modelled: 13 Confidence: 19.9% Identity: 46% PDB header:proton transport Chain: 7: PDB Molecule:mitochondrial atp synthase associated protein asa7; PDBTitle: cryoem structure of polytomella f-atp synthase, primary rotary state2 3, monomer-masked refinement Phyre2 PDB 1x27 chain F Region: 519 - 568 Aligned: 44 Modelled: 50 Confidence: 19.5% Identity: 23% PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas Phyre2 PDB 2vld chain A Region: 555 - 589 Aligned: 35 Modelled: 35 Confidence: 19.2% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:endonuclease nucs; PDBTitle: crystal structure of a repair endonuclease from pyrococcus abyssi Phyre2 1 d2r6gf1 2 d1fo1a2 3 c3hi2C_ 4 c3lzkC_ 5 c2l6pA_ 6 d1kpta_ 7 d1b4ra_ 8 c2hjjA_ 9 d2hjja1 10 c5jpqi_ 11 c2l6nA_ 12 c2ifoA_ 13 d1tisa_ 14 c2zpaB_ 15 c2xu9A_ 16 d1wgoa_ 17 c3iynR_ 18 c6rdf7_ 19 c1x27F_ 20 c2vldA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99