1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	A	V	F	G	C	A	I	A	V	V	G	I	A	G	S	V	V	A	G	P	A	D	I	H	L	V	A	A	K	Q	S	Y	G	F	A	V	A	S	V	L	P	T	R	G	Q	V	V	G	V	A	H	P	V	V	V	T	F	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	P	I	T	N	P	A	N	R	H	A	A	E	R	A	V	E	V	K	S	T	P	A	M	T	G	K	F	E	W	L	D	N	D	V	V	Q	W	V	P	D	R	F	W	P	A	H	S	T	V	E	L	S	V	G	S	L	S	S	D
Secondary structure
SS confidence
Disorder												?	?	?							?																																			?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	K	T	G	P	A	V	V	G	V	A	S	I	S	Q	H	T	F	T	V	S	I	D	G	V	E	E	G	P	P	P	P	L	P	A	P	H	H	R	V	H	F	G	E	D	G	V	M	P	A	S	M	G	R	P	E	Y	P	T	P
Secondary structure
SS confidence
Disorder																																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	G	S	Y	T	V	L	S	K	E	R	S	V	I	M	D	S	S	S	V	G	I	P	V	D	D	P	D	G	Y	R	L	S	V	D	Y	A	V	R	I	T	S	R	G	L	Y	V	H	S	A	P	W	A	L	P	A	L	G	L	E
Secondary structure
SS confidence
Disorder													?				?			?		?																																	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.
Sequence		N	V	S	H	G	C	I	S	L	S	R	E	D	A	E	W	Y	Y	N	A	V	D	I	G	D	P	V	I	V	Q	E
Secondary structure
SS confidence
Disorder																																?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 7%) Beta strand ( 51%)

Rank Aligned region

PDB 3vyn chain B Region: 3 - 270 Aligned: 253 Modelled: 268 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: B: PDB Molecule:probable conserved lipoprotein lpps; PDBTitle: crystal structure of mycobacterium tuberculosis l,d-transpeptidase2 ldtmt2 n55 truncation mutant (resideus 55-408) Phyre2 PDB 3u1q chain B Region: 36 - 270 Aligned: 224 Modelled: 233 Confidence: 100.0% Identity: 38% PDB header:peptidoglycan binding protein Chain: B: PDB Molecule:mycobacteria tuberculosis ld-transpeptidase type 2; PDBTitle: crystal structure of m. tuberculosis ld-transpeptidase type 2 with 2-2 mercaptoethanol Phyre2 PDB 4z7a chain A Region: 3 - 270 Aligned: 241 Modelled: 268 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:mycobacterium tuberculosis (3,3)l,d-transpeptidase type 5; PDBTitle: structural and biochemical characterization of a non-functionally2 redundant m. tuberculosis (3,3) l,d-transpeptidase, ldtmt5. Phyre2 PDB 4k73 chain A Region: 33 - 271 Aligned: 221 Modelled: 239 Confidence: 100.0% Identity: 98% PDB header:transferase Chain: A: PDB Molecule:l,d-transpeptidase; PDBTitle: x-ray crystal structure of an l,d-transpeptidase from mycobacterium2 tuberculosis h37rv Phyre2 PDB 4xvo chain B Region: 35 - 270 Aligned: 211 Modelled: 215 Confidence: 100.0% Identity: 50% PDB header:transferase Chain: B: PDB Molecule:l,d-transpeptidase; PDBTitle: l,d-transpeptidase from mycobacterium smegmatis Phyre2 PDB 4jmx chain A Region: 36 - 269 Aligned: 209 Modelled: 218 Confidence: 100.0% Identity: 50% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:probable l,d-transpeptidase ldta; PDBTitle: structure of ld transpeptidase ldtmt1 in complex with imipenem Phyre2 PDB 2hkl chain B Region: 51 - 270 Aligned: 206 Modelled: 220 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:l,d-transpeptidase; PDBTitle: crystal structure of enterococcus faecium l,d-2 transpeptidase c442s mutant Phyre2 PDB 5bmq chain A Region: 144 - 270 Aligned: 112 Modelled: 127 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:erfk/ybis/ycfs/ynhg family protein; PDBTitle: crystal structure of l,d-transpeptidase (yku) from stackebrandtia2 nassauensis Phyre2 PDB 1y7m chain A domain 1 Region: 149 - 270 Aligned: 104 Modelled: 106 Confidence: 99.9% Identity: 19% Fold: L,D-transpeptidase catalytic domain-like Superfamily: L,D-transpeptidase catalytic domain-like Family: L,D-transpeptidase catalytic domain-like Phyre2 PDB 1zat chain A domain 1 Region: 151 - 269 Aligned: 112 Modelled: 119 Confidence: 99.9% Identity: 27% Fold: L,D-transpeptidase catalytic domain-like Superfamily: L,D-transpeptidase catalytic domain-like Family: L,D-transpeptidase catalytic domain-like Phyre2 PDB 4hu2 chain A Region: 3 - 141 Aligned: 129 Modelled: 137 Confidence: 99.9% Identity: 29% PDB header:unknown function Chain: A: PDB Molecule:probable conserved lipoprotein lpps; PDBTitle: crystal structure of ldtmt2, a l,d-transpeptidase from mycobacterium2 tuberculosis: domain a and b Phyre2 PDB 1y7m chain B Region: 148 - 270 Aligned: 105 Modelled: 107 Confidence: 99.9% Identity: 19% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein bsu14040; PDBTitle: crystal structure of the b. subtilis ykud protein at 2 a2 resolution Phyre2 PDB 4lzh chain A Region: 151 - 269 Aligned: 111 Modelled: 119 Confidence: 99.9% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:l,d-transpeptidase; PDBTitle: l,d-transpeptidase from klebsiella pneumoniae Phyre2 PDB 4lpq chain A Region: 149 - 270 Aligned: 116 Modelled: 121 Confidence: 99.8% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:erfk/ybis/ycfs/ynhg family protein; PDBTitle: crystal structure of the l,d-transpeptidase (residues 123-326) from2 xylanimonas cellulosilytica dsm 15894 Phyre2 PDB 4xxt chain A Region: 148 - 269 Aligned: 104 Modelled: 105 Confidence: 99.8% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:fusion of predicted zn-dependent amidase/peptidase (cell PDBTitle: crystal structure of fused zn-dependent2 amidase/peptidase/peptodoglycan-binding domain-containing protein3 from clostridium acetobutylicum atcc 824 Phyre2 PDB 4y4v chain B Region: 147 - 269 Aligned: 117 Modelled: 123 Confidence: 99.7% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:conserved hypothetical secreted protein; PDBTitle: structure of helicobacter pylori csd6 in the d-ala-bound state Phyre2 PDB 6ntw chain A Region: 151 - 259 Aligned: 109 Modelled: 109 Confidence: 98.9% Identity: 20% PDB header:transferase/transferase inhibitor Chain: A: PDB Molecule:probable l,d-transpeptidase ycbb; PDBTitle: crystal structure of e. coli ycbb Phyre2 PDB 1zat chain A domain 2 Region: 20 - 87 Aligned: 62 Modelled: 68 Confidence: 91.7% Identity: 6% Fold: L,D-transpeptidase pre-catalytic domain-like Superfamily: L,D-transpeptidase pre-catalytic domain-like Family: L,D-transpeptidase pre-catalytic domain-like Phyre2 PDB 6pax chain A domain 1 Region: 223 - 247 Aligned: 25 Modelled: 25 Confidence: 33.2% Identity: 32% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Paired domain Phyre2 PDB 1cz5 chain A domain 1 Region: 244 - 270 Aligned: 25 Modelled: 27 Confidence: 31.7% Identity: 20% Fold: Double psi beta-barrel Superfamily: ADC-like Family: Cdc48 N-terminal domain-like Phyre2 1 c3vynB_ 2 c3u1qB_ 3 c4z7aA_ 4 c4k73A_ 5 c4xvoB_ 6 c4jmxA_ 7 c2hklB_ 8 c5bmqA_ 9 d1y7ma1 10 d1zata1 11 c4hu2A_ 12 c1y7mB_ 13 c4lzhA_ 14 c4lpqA_ 15 c4xxtA_ 16 c4y4vB_ 17 c6ntwA_ 18 d1zata2 19 d6paxa1 20 d1cz5a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99