1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	V	A	N	L	K	D	L	L	A	E	G	V	S	G	R	G	V	L	V	R	S	D	L	N	V	P	L	D	E	D	G	T	I	T	D	A	G	R	I	I	A	S	A	P	T	L	K	A	L	L	D	A	D	A	K	V	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?			?	?																						?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	H	L	G	R	P	K	D	G	P	D	P	T	L	S	L	A	P	V	A	V	A	L	G	E	Q	L	G	R	H	V	Q	L	A	G	D	V	V	G	A	D	A	L	A	R	A	E	G	L	T	G	G	D	I	L	L	L	E	N
Secondary structure
SS confidence
Disorder								?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	R	F	D	K	R	E	T	S	K	N	D	D	D	R	R	A	L	A	K	Q	L	V	E	L	V	G	T	G	G	V	F	V	S	D	G	F	G	V	V	H	R	K	Q	A	S	V	Y	D	I	A	T	L	L	P	H	Y	A	G	T
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	V	A	D	E	M	R	V	L	E	Q	L	T	S	S	T	Q	R	P	Y	A	V	V	L	G	G	S	K	V	S	D	K	L	G	V	I	E	S	L	A	T	K	A	D	S	I	V	I	G	G	G	M	C	F	T	F	L	A	A	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	F	S	V	G	T	S	L	L	E	D	D	M	I	E	V	C	R	G	L	L	E	T	Y	H	D	V	L	R	L	P	V	D	L	V	V	T	E	K	F	A	A	D	S	P	P	Q	T	V	D	V	G	A	V	P	N	G	L	M	G
Secondary structure
SS confidence
Disorder																																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	D	I	G	P	G	S	I	K	R	F	S	T	L	L	S	N	A	G	T	I	F	W	N	G	P	M	G	V	F	E	F	P	A	Y	A	A	G	T	R	G	V	A	E	A	I	V	A	A	T	G	K	G	A	F	S	V	V	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.
Sequence		G	D	S	A	A	A	V	R	A	M	N	I	P	E	G	A	F	S	H	I	S	T	G	G	G	A	S	L	E	Y	L	E	G	K	T	L	P	G	I	E	V	L	S	R	E	Q	P	T	G	G	V	L
Secondary structure
SS confidence
Disorder																?																																		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 44%) Beta strand ( 18%)

Rank Aligned region

PDB 1php chain A Region: 1 - 405 Aligned: 391 Modelled: 405 Confidence: 100.0% Identity: 44% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 1vpe chain A Region: 5 - 405 Aligned: 392 Modelled: 401 Confidence: 100.0% Identity: 47% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 4dg5 chain A Region: 5 - 405 Aligned: 394 Modelled: 401 Confidence: 100.0% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of staphylococcal phosphoglycerate kinase Phyre2 PDB 3zlb chain A Region: 1 - 405 Aligned: 395 Modelled: 405 Confidence: 100.0% Identity: 44% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from streptococcus2 pneumoniae Phyre2 PDB 3q3v chain A Region: 5 - 404 Aligned: 388 Modelled: 400 Confidence: 100.0% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from campylobacter2 jejuni. Phyre2 PDB 16pk chain A Region: 5 - 405 Aligned: 394 Modelled: 401 Confidence: 100.0% Identity: 41% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 1v6s chain A Region: 6 - 403 Aligned: 386 Modelled: 398 Confidence: 100.0% Identity: 49% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 1vjd chain A Region: 2 - 404 Aligned: 400 Modelled: 403 Confidence: 100.0% Identity: 39% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 1qpg chain A Region: 2 - 405 Aligned: 401 Modelled: 404 Confidence: 100.0% Identity: 38% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 5bt8 chain D Region: 1 - 405 Aligned: 382 Modelled: 405 Confidence: 100.0% Identity: 42% PDB header:transferase Chain: D: PDB Molecule:phosphoglycerate kinase; PDBTitle: x-ray crystal structure of phosphoglycerate kinase from acinetobacter2 baumannii Phyre2 PDB 1ltk chain A Region: 2 - 404 Aligned: 400 Modelled: 403 Confidence: 100.0% Identity: 37% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 2cun chain A Region: 6 - 406 Aligned: 393 Modelled: 399 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of phosphoglycerate kinase from pyrococcus2 horikoshii ot3 Phyre2 PDB 4ng4 chain B Region: 6 - 405 Aligned: 381 Modelled: 400 Confidence: 100.0% Identity: 39% PDB header:transferase Chain: B: PDB Molecule:phosphoglycerate kinase; PDBTitle: structure of phosphoglycerate kinase (cbu_1782) from coxiella burnetii Phyre2 PDB 1zmr chain A Region: 5 - 406 Aligned: 382 Modelled: 402 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: crystal structure of the e. coli phosphoglycerate kinase Phyre2 PDB 1hdi chain A Region: 5 - 404 Aligned: 397 Modelled: 400 Confidence: 100.0% Identity: 38% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 4ehj chain A Region: 5 - 405 Aligned: 383 Modelled: 401 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: A: PDB Molecule:phosphoglycerate kinase; PDBTitle: an x-ray structure of a putative phosphogylcerate kinase from2 francisella tularensis subsp. tularensis schu s4 Phyre2 PDB 1fw8 chain A Region: 73 - 405 Aligned: 331 Modelled: 333 Confidence: 100.0% Identity: 38% Fold: Phosphoglycerate kinase Superfamily: Phosphoglycerate kinase Family: Phosphoglycerate kinase Phyre2 PDB 3zvm chain A Region: 15 - 175 Aligned: 130 Modelled: 130 Confidence: 89.1% Identity: 22% PDB header:hydrolase/transferase/dna Chain: A: PDB Molecule:bifunctional polynucleotide phosphatase/kinase; PDBTitle: the structural basis for substrate recognition by mammalian2 polynucleotide kinase 3' phosphatase Phyre2 PDB 1yj5 chain A domain 1 Region: 15 - 175 Aligned: 134 Modelled: 134 Confidence: 88.5% Identity: 21% Fold: HAD-like Superfamily: HAD-like Family: phosphatase domain of polynucleotide kinase Phyre2 PDB 1yj5 chain B Region: 15 - 175 Aligned: 134 Modelled: 134 Confidence: 87.3% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:5' polynucleotide kinase-3' phosphatase catalytic domain; PDBTitle: molecular architecture of mammalian polynucleotide kinase, a dna2 repair enzyme Phyre2 1 d1phpa_ 2 d1vpea_ 3 c4dg5A_ 4 c3zlbA_ 5 c3q3vA_ 6 d16pka_ 7 d1v6sa_ 8 d1vjda_ 9 d1qpga_ 10 c5bt8D_ 11 d1ltka_ 12 c2cunA_ 13 c4ng4B_ 14 c1zmrA_ 15 d1hdia_ 16 c4ehjA_ 17 d1fw8a_ 18 c3zvmA_ 19 d1yj5a1 20 c1yj5B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99