1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	M	S	A	S	N	A	F	V	E	G	F	A	D	F	W	K	A	P	S	P	D	R	L	T	D	H	L	H	P	D	V	V	L	V	R	P	L	S	P	P	R	H	G	L	G	A	A	Q	R	E	F	T	R	I	L	G	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																		?																?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	D	L	H	G	E	V	D	R	W	S	Q	A	G	D	V	V	F	I	E	F	R	L	I	A	R	L	G	S	E	V	V	E	W	P	V	V	D	R	F	L	L	R	G	D	K	A	V	E	R	V	S	Y	F	D	S	L	P	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.
Sequence		I	K	V	V	K	H	P	S	A	W	R	G	W	L	T	T	M	R	S	R	A
Secondary structure
SS confidence
Disorder																			?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 74%) Beta strand ( 8%)

Rank Aligned region

PDB 2bng chain A domain 1 Region: 2 - 120 Aligned: 118 Modelled: 117 Confidence: 98.4% Identity: 18% Fold: Cystatin-like Superfamily: NTF2-like Family: Limonene-1,2-epoxide hydrolase-like Phyre2 PDB 5aig chain A Region: 3 - 123 Aligned: 120 Modelled: 121 Confidence: 98.3% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:limonene-1,2-epoxide hydrolase; PDBTitle: discovery and characterization of thermophilic limonene-1,2-epoxide2 hydrolases from hot spring metagenomic libraries. tomsk-sample-3 valpromide complex Phyre2 PDB 1nww chain A Region: 1 - 120 Aligned: 120 Modelled: 120 Confidence: 98.3% Identity: 17% Fold: Cystatin-like Superfamily: NTF2-like Family: Limonene-1,2-epoxide hydrolase-like Phyre2 PDB 2gey chain A domain 1 Region: 3 - 127 Aligned: 123 Modelled: 123 Confidence: 98.2% Identity: 22% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 3k0z chain B Region: 9 - 122 Aligned: 114 Modelled: 114 Confidence: 98.1% Identity: 14% PDB header:lyase Chain: B: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of putative polyketide cyclase (np_977253.1) from2 bacillus cereus atcc 10987 at 1.91 a resolution Phyre2 PDB 3f9s chain B Region: 3 - 123 Aligned: 121 Modelled: 121 Confidence: 98.1% Identity: 12% PDB header:lyase Chain: B: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (lferr_0659) from2 acidithiobacillus ferrooxidans atcc at 1.76 a resolution Phyre2 PDB 5x7l chain A Region: 1 - 120 Aligned: 118 Modelled: 120 Confidence: 98.0% Identity: 21% PDB header:isomerase Chain: A: PDB Molecule:tsrd; PDBTitle: structure of tsrd from streptomyces laurentii Phyre2 PDB 3ehc chain A Region: 5 - 123 Aligned: 115 Modelled: 119 Confidence: 98.0% Identity: 13% PDB header:unknown function Chain: A: PDB Molecule:snoal-like polyketide cyclase; PDBTitle: crystal structure of a snoal-like polyketide cyclase (atu3018) from2 agrobacterium tumefaciens str. c58 at 2.12 a resolution Phyre2 PDB 3h3h chain A Region: 1 - 82 Aligned: 82 Modelled: 82 Confidence: 97.7% Identity: 23% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized snoal-like protein; PDBTitle: crystal structure of a snoal-like protein of unknown function2 (bth_ii0226) from burkholderia thailandensis e264 at 1.60 a3 resolution Phyre2 PDB 5evh chain A Region: 8 - 119 Aligned: 106 Modelled: 106 Confidence: 97.6% Identity: 13% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of known function protein from kribbella flavida dsm2 17836 Phyre2 PDB 1s5a chain A Region: 2 - 120 Aligned: 119 Modelled: 119 Confidence: 97.6% Identity: 13% Fold: Cystatin-like Superfamily: NTF2-like Family: PhzA/PhzB-like Phyre2 PDB 1oh0 chain A Region: 8 - 115 Aligned: 108 Modelled: 108 Confidence: 97.6% Identity: 12% Fold: Cystatin-like Superfamily: NTF2-like Family: Ketosteroid isomerase-like Phyre2 PDB 2gex chain A domain 1 Region: 3 - 129 Aligned: 126 Modelled: 127 Confidence: 97.5% Identity: 21% Fold: Cystatin-like Superfamily: NTF2-like Family: SnoaL-like polyketide cyclase Phyre2 PDB 3kkg chain A Region: 13 - 127 Aligned: 115 Modelled: 115 Confidence: 97.4% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:putative snoal-like polyketide cyclase; PDBTitle: crystal structure of putative snoal-like polyketide cyclase2 (yp_509242.1) from jannaschia sp. ccs1 at 1.40 a resolution Phyre2 PDB 3dm8 chain A domain 1 Region: 1 - 124 Aligned: 124 Modelled: 124 Confidence: 97.4% Identity: 10% Fold: Cystatin-like Superfamily: NTF2-like Family: Rpa4348-like Phyre2 PDB 3mso chain A Region: 8 - 123 Aligned: 112 Modelled: 116 Confidence: 97.2% Identity: 21% PDB header:isomerase Chain: A: PDB Molecule:steroid delta-isomerase; PDBTitle: crystal structure of a steroid delta-isomerase (np_250810.1) from2 pseudomonas aeruginosa at 2.57 a resolution Phyre2 PDB 4h3u chain B Region: 9 - 130 Aligned: 121 Modelled: 122 Confidence: 97.2% Identity: 19% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of hypothetical protein with ketosteroid isomerase-2 like protein fold from catenulispora acidiphila dsm 44928 Phyre2 PDB 1ohp chain A domain 1 Region: 8 - 115 Aligned: 107 Modelled: 108 Confidence: 97.1% Identity: 18% Fold: Cystatin-like Superfamily: NTF2-like Family: Ketosteroid isomerase-like Phyre2 PDB 3f8h chain A Region: 1 - 115 Aligned: 115 Modelled: 115 Confidence: 97.1% Identity: 17% PDB header:unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (tm1040_3560) from2 silicibacter sp. tm1040 at 2.00 a resolution Phyre2 PDB 3i0y chain C Region: 4 - 123 Aligned: 120 Modelled: 120 Confidence: 97.1% Identity: 14% PDB header:isomerase Chain: C: PDB Molecule:putative polyketide cyclase; PDBTitle: crystal structure of a putative polyketide cyclase (xcc0381) from2 xanthomonas campestris pv. campestris at 1.50 a resolution Phyre2 1 d2bnga1 2 c5aigA_ 3 d1nwwa_ 4 d2geya1 5 c3k0zB_ 6 c3f9sB_ 7 c5x7lA_ 8 c3ehcA_ 9 c3h3hA_ 10 c5evhA_ 11 d1s5aa_ 12 d1oh0a_ 13 d2gexa1 14 c3kkgA_ 15 d3dm8a1 16 c3msoA_ 17 c4h3uB_ 18 d1ohpa1 19 c3f8hA_ 20 c3i0yC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92