1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	V	D	L	P	D	T	T	T	T	A	V	N	K	K	L	D	E	L	R	E	K	I	G	A	V	A	M	G	R	V	L	T	L	I	I	A	P	D	S	E	A	M	L	E	E	S	I	E	A	A	N	D	A	S	H	E	H	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	R	I	I	V	T	M	R	G	D	P	Y	A	D	R	P	R	L	D	A	Q	L	R	V	G	A	D	A	G	A	G	E	F	V	V	L	R	L	S	G	P	L	A	G	H	A	D	S	V	V	I	P	F	L	L	P	D	I	P	V
Secondary structure
SS confidence
Disorder									?		?	?	?	?	?	?	?	?																								?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	A	W	W	P	D	I	A	P	A	V	P	A	Q	D	A	L	G	K	L	A	I	R	R	I	T	D	A	T	N	A	I	D	P	L	S	A	I	K	S	R	L	A	G	Y	G	A	G	D	T	D	L	A	W	S	R	I	T	Y	W
Secondary structure
SS confidence
Disorder											?		?																															?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	A	L	L	T	S	A	V	D	Q	P	R	H	E	P	I	E	S	A	L	V	S	G	L	K	T	E	P	A	L	D	V	L	A	G	W	L	A	S	R	I	E	G	P	V	R	R	A	V	G	E	L	K	V	E	L	V	R	N	S
Secondary structure
SS confidence
Disorder																																															?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		E	T	I	V	L	S	R	P	Q	E	G	I	T	A	T	L	T	R	T	G	K	P	D	A	L	V	P	L	A	R	R	V	T	G	E	C	L	A	E	D	L	R	R	L	D	P	D	E	I	Y	C	A	A	L	E	G	I	K	K	V
Secondary structure
SS confidence
Disorder									?	?	?	?							?	?	?	?		?								?	?																											?	?
Disorder confidence
		.	.	.
Sequence		Q	Y	R
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 33%) Beta strand ( 29%)

Rank Aligned region

PDB 1kl7 chain A Region: 115 - 227 Aligned: 109 Modelled: 113 Confidence: 77.0% Identity: 16% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 1miu chain A domain 4 Region: 85 - 99 Aligned: 15 Modelled: 15 Confidence: 24.5% Identity: 27% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Single strand DNA-binding domain, SSB Phyre2 PDB 6ojm chain B Region: 41 - 155 Aligned: 112 Modelled: 113 Confidence: 22.3% Identity: 15% PDB header:lyase Chain: B: PDB Molecule:1,4-dihydroxy-2-naphthoyl-coa synthase; PDBTitle: crystal structure of 1,4-dihydroxy-2-naphthoyl-coa synthase2 elizabethkingia anophelis nuhp1 Phyre2 PDB 3k12 chain F Region: 10 - 80 Aligned: 70 Modelled: 71 Confidence: 21.9% Identity: 17% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:uncharacterized protein a6v7t0; PDBTitle: crystal structure of an uncharacterized protein a6v7t0 from2 pseudomonas aeruginosa Phyre2 PDB 1r0l chain D Region: 36 - 107 Aligned: 65 Modelled: 72 Confidence: 19.8% Identity: 14% PDB header:oxidoreductase Chain: D: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: 1-deoxy-d-xylulose 5-phosphate reductoisomerase from zymomonas mobilis2 in complex with nadph Phyre2 PDB 1rm6 chain A domain 2 Region: 178 - 226 Aligned: 49 Modelled: 49 Confidence: 19.0% Identity: 22% Fold: Molybdenum cofactor-binding domain Superfamily: Molybdenum cofactor-binding domain Family: Molybdenum cofactor-binding domain Phyre2 PDB 1dgj chain A domain 4 Region: 178 - 226 Aligned: 49 Modelled: 49 Confidence: 17.3% Identity: 12% Fold: Molybdenum cofactor-binding domain Superfamily: Molybdenum cofactor-binding domain Family: Molybdenum cofactor-binding domain Phyre2 PDB 1ohu chain A Region: 124 - 177 Aligned: 52 Modelled: 54 Confidence: 16.7% Identity: 8% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 1vb3 chain A domain 1 Region: 173 - 227 Aligned: 54 Modelled: 55 Confidence: 16.0% Identity: 30% Fold: Tryptophan synthase beta subunit-like PLP-dependent enzymes Superfamily: Tryptophan synthase beta subunit-like PLP-dependent enzymes Family: Tryptophan synthase beta subunit-like PLP-dependent enzymes Phyre2 PDB 4f4f chain B Region: 172 - 227 Aligned: 54 Modelled: 56 Confidence: 14.7% Identity: 19% PDB header:lyase Chain: B: PDB Molecule:threonine synthase; PDBTitle: x-ray crystal structure of plp bound threonine synthase from brucella2 melitensis Phyre2 PDB 1ffg chain B Region: 263 - 285 Aligned: 23 Modelled: 23 Confidence: 14.2% Identity: 26% Fold: Ferredoxin-like Superfamily: CheY-binding domain of CheA Family: CheY-binding domain of CheA Phyre2 PDB 1iyj chain B domain 4 Region: 85 - 99 Aligned: 15 Modelled: 15 Confidence: 13.5% Identity: 27% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Single strand DNA-binding domain, SSB Phyre2 PDB 1nye chain D Region: 203 - 247 Aligned: 45 Modelled: 45 Confidence: 13.5% Identity: 11% Fold: OsmC-like Superfamily: OsmC-like Family: Ohr/OsmC resistance proteins Phyre2 PDB 5bvl chain A Region: 285 - 303 Aligned: 19 Modelled: 19 Confidence: 13.4% Identity: 37% PDB header:de novo protein Chain: A: PDB Molecule:designed tim barrel stim11; PDBTitle: crystal structure of a de novo designed tim-barrel Phyre2 PDB 3oss chain D Region: 2 - 55 Aligned: 54 Modelled: 54 Confidence: 12.6% Identity: 13% PDB header:protein transport Chain: D: PDB Molecule:type 2 secretion system, secretin gspd; PDBTitle: the crystal structure of enterotoxigenic escherichia coli gspc-gspd2 complex from the type ii secretion system Phyre2 PDB 1efp chain B Region: 213 - 259 Aligned: 43 Modelled: 47 Confidence: 12.4% Identity: 21% Fold: Adenine nucleotide alpha hydrolase-like Superfamily: Adenine nucleotide alpha hydrolases-like Family: ETFP subunits Phyre2 PDB 3hrd chain E Region: 181 - 226 Aligned: 46 Modelled: 46 Confidence: 11.9% Identity: 22% PDB header:oxidoreductase Chain: E: PDB Molecule:nicotinate dehydrogenase large molybdopterin PDBTitle: crystal structure of nicotinate dehydrogenase Phyre2 PDB 3v7n chain A Region: 173 - 227 Aligned: 54 Modelled: 55 Confidence: 11.7% Identity: 15% PDB header:lyase Chain: A: PDB Molecule:threonine synthase; PDBTitle: crystal structure of threonine synthase (thrc) from from burkholderia2 thailandensis Phyre2 PDB 1o94 chain D Region: 213 - 268 Aligned: 52 Modelled: 56 Confidence: 11.7% Identity: 17% PDB header:electron transport Chain: D: PDB Molecule:electron transfer flavoprotein alpha-subunit; PDBTitle: ternary complex between trimethylamine dehydrogenase and2 electron transferring flavoprotein Phyre2 PDB 5vld chain C Region: 11 - 59 Aligned: 44 Modelled: 49 Confidence: 11.0% Identity: 27% PDB header:oxidoreductase Chain: C: PDB Molecule:histidinol dehydrogenase, chloroplastic; PDBTitle: crystal structure of medicago truncatula l-histidinol dehydrogenase in2 complex with l-histidine and nad+ Phyre2 1 d1kl7a_ 2 d1miua4 3 c6ojmB_ 4 c3k12F_ 5 c1r0lD_ 6 d1rm6a2 7 d1dgja4 8 d1ohua_ 9 d1vb3a1 10 c4f4fB_ 11 d1ffgb_ 12 d1iyjb4 13 d1nyed_ 14 c5bvlA_ 15 c3ossD_ 16 d1efpb_ 17 c3hrdE_ 18 c3v7nA_ 19 c1o94D_ 20 c5vldC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96