1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	A	Q	N	P	N	L	A	A	L	S	A	A	G	V	S	V	W	L	D	D	L	S	R	D	R	L	R	S	G	N	L	Q	E	L	I	D	T	K	S	V	V	G	V	T	T	N	P	S	I	F	Q	K	A	L	S	E	G	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																																			?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	Y	D	A	Q	I	A	E	L	A	A	R	G	A	D	V	D	A	T	I	R	T	V	T	T	D	D	V	R	S	A	C	D	V	L	V	P	Q	W	E	D	S	D	G	V	D	G	R	V	S	I	E	V	D	P	R	L	A	H	E
Secondary structure
SS confidence
Disorder																																									?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	E	K	T	I	Q	Q	A	I	E	L	W	K	I	V	D	R	P	N	L	F	I	K	I	P	A	T	K	A	G	L	P	A	I	S	A	V	L	A	E	G	I	S	V	N	V	T	L	I	F	S	V	Q	R	Y	R	E	V	M	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	Y	L	T	G	M	E	K	A	R	Q	A	G	H	S	L	S	K	I	H	S	V	A	S	F	F	V	S	R	V	D	T	E	I	D	K	R	L	D	R	I	G	S	R	Q	A	L	E	L	R	G	Q	A	G	V	A	N	A	R	L
Secondary structure
SS confidence
Disorder												?	?		?	?	?																									?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	Y	A	T	Y	R	E	V	F	E	D	S	D	R	Y	R	S	L	K	V	D	G	A	R	V	Q	R	P	L	W	A	S	T	G	V	K	N	P	D	Y	S	D	T	L	Y	V	T	E	L	V	A	P	H	T	V	N	T	M	P	E
Secondary structure
SS confidence
Disorder																					?	?	?	?								?			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	T	I	D	A	V	A	D	H	G	V	I	Q	G	D	T	V	T	G	T	A	S	D	A	Q	A	V	F	D	Q	L	G	A	I	G	I	D	L	T	D	V	F	A	V	L	E	E	E	G	V	R	K	F	E	A	S	W	N	E	L
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.
Sequence		L	Q	E	T	R	A	H	L	D	T	A	A	Q
Secondary structure
SS confidence
Disorder													?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 60%) Beta strand ( 8%)

Rank Aligned region

PDB 3r5e chain A Region: 5 - 369 Aligned: 359 Modelled: 365 Confidence: 100.0% Identity: 62% PDB header:transferase Chain: A: PDB Molecule:transaldolase; PDBTitle: transaldolase from corynebacterium glutamicum Phyre2 PDB 3clm chain A Region: 8 - 364 Aligned: 347 Modelled: 357 Confidence: 100.0% Identity: 40% PDB header:lyase Chain: A: PDB Molecule:transaldolase; PDBTitle: crystal structure of transaldolase (yp_208650.1) from neisseria2 gonorrhoeae fa 1090 at 1.14 a resolution Phyre2 PDB 3hjz chain A Region: 15 - 371 Aligned: 313 Modelled: 317 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:transaldolase b; PDBTitle: the structure of an aldolase from prochlorococcus marinus Phyre2 PDB 2e1d chain A domain 1 Region: 19 - 368 Aligned: 303 Modelled: 309 Confidence: 100.0% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3m16 chain A Region: 2 - 370 Aligned: 314 Modelled: 321 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:transaldolase; PDBTitle: structure of a transaldolase from oleispira antarctica Phyre2 PDB 1f05 chain A Region: 20 - 368 Aligned: 302 Modelled: 318 Confidence: 100.0% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3igx chain A Region: 20 - 368 Aligned: 305 Modelled: 306 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:transaldolase; PDBTitle: 1.85 angstrom resolution crystal structure of transaldolase b (tala)2 from francisella tularensis. Phyre2 PDB 3cq0 chain B Region: 8 - 370 Aligned: 299 Modelled: 323 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:putative transaldolase ygr043c; PDBTitle: crystal structure of tal2_yeast Phyre2 PDB 1onr chain A Region: 20 - 368 Aligned: 302 Modelled: 311 Confidence: 100.0% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3s1v chain D Region: 18 - 360 Aligned: 211 Modelled: 229 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: D: PDB Molecule:probable transaldolase; PDBTitle: transaldolase from thermoplasma acidophilum in complex with d-fructose2 6-phosphate schiff-base intermediate Phyre2 PDB 1vpx chain A Region: 14 - 364 Aligned: 205 Modelled: 216 Confidence: 100.0% Identity: 32% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 1wx0 chain A domain 1 Region: 18 - 309 Aligned: 200 Modelled: 228 Confidence: 100.0% Identity: 36% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 1l6w chain A Region: 18 - 360 Aligned: 210 Modelled: 221 Confidence: 100.0% Identity: 27% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3r8r chain J Region: 18 - 359 Aligned: 202 Modelled: 221 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: J: PDB Molecule:transaldolase; PDBTitle: transaldolase from bacillus subtilis Phyre2 PDB 1o66 chain A Region: 115 - 194 Aligned: 77 Modelled: 80 Confidence: 78.7% Identity: 19% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Ketopantoate hydroxymethyltransferase PanB Phyre2 PDB 3ez4 chain B Region: 1 - 220 Aligned: 172 Modelled: 190 Confidence: 69.1% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:3-methyl-2-oxobutanoate hydroxymethyltransferase; PDBTitle: crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase2 from burkholderia pseudomallei Phyre2 PDB 3i10 chain A Region: 8 - 58 Aligned: 51 Modelled: 51 Confidence: 38.5% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:putative glycerophosphoryl diester phosphodiesterase; PDBTitle: crystal structure of putative glycerophosphoryl diester2 phosphodiesterase (np_812074.1) from bacteroides thetaiotaomicron3 vpi-5482 at 1.35 a resolution Phyre2 PDB 3ezi chain B Region: 173 - 214 Aligned: 42 Modelled: 42 Confidence: 31.3% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:nitrate/nitrite sensor protein narx; PDBTitle: crystal structure of the e. coli histidine kinase narx sensor domain2 without ligand Phyre2 PDB 4kbx chain A Region: 46 - 183 Aligned: 87 Modelled: 90 Confidence: 23.7% Identity: 20% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein yhfx; PDBTitle: crystal structure of the pyridoxal-5'-phosphate dependent protein yhfx2 from escherichia coli Phyre2 PDB 1gqk chain B Region: 14 - 111 Aligned: 70 Modelled: 75 Confidence: 22.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:alpha-d-glucuronidase; PDBTitle: structure of pseudomonas cellulosa alpha-d-glucuronidase complexed2 with glucuronic acid Phyre2 1 c3r5eA_ 2 c3clmA_ 3 c3hjzA_ 4 d2e1da1 5 c3m16A_ 6 d1f05a_ 7 c3igxA_ 8 c3cq0B_ 9 d1onra_ 10 c3s1vD_ 11 d1vpxa_ 12 d1wx0a1 13 d1l6wa_ 14 c3r8rJ_ 15 d1o66a_ 16 c3ez4B_ 17 c3i10A_ 18 c3eziB_ 19 c4kbxA_ 20 c1gqkB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99