1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	N	V	R	G	R	V	A	P	R	R	V	T	G	R	A	M	S	T	L	L	A	Y	L	A	L	T	K	P	R	V	I	E	L	L	L	V	T	A	I	P	A	M	L	L	A	D	R	G	A	I	H	P	L	L	M	L	N	T	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	G	G	M	M	A	A	A	G	A	N	T	L	N	C	V	A	D	A	D	I	D	K	V	M	K	R	T	A	R	R	P	L	A	R	E	A	V	P	T	R	N	A	L	A	L	G	L	T	L	T	V	I	S	F	F	W	L	W	C
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	T	N	L	L	A	G	V	L	A	L	V	T	V	A	F	Y	V	F	V	Y	T	L	W	L	K	R	R	T	S	Q	N	V	V	W	G	G	A	A	G	C	M	P	V	M	I	G	W	S	A	I	T	G	T	I	A	W	P	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	M	F	A	I	I	F	F	W	T	P	P	H	T	W	A	L	A	M	R	Y	K	Q	D	Y	Q	V	A	G	V	P	M	L	P	A	V	A	T	E	R	Q	V	T	K	Q	I	L	I	Y	T	W	L	T	V	A	A	T	L	V	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	L	A	T	S	W	L	Y	G	A	V	A	L	V	A	G	G	W	F	L	T	M	A	H	Q	L	Y	A	G	V	R	A	G	E	P	V	R	P	L	R	L	F	L	Q	S	N	N	Y	L	A	V	V	F	C	A	L	A	V	D	S
Secondary structure
SS confidence
Disorder																													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.
Sequence		V	I	A	L	P	T	L	H
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 78%) Beta strand ( 1%) TM helix ( 59%) (View membrane topology prediction)

Rank Aligned region

PDB 4od5 chain C Region: 25 - 299 Aligned: 266 Modelled: 275 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: C: PDB Molecule:4-hydroxybenzoate octaprenyltransferase; PDBTitle: substrate-bound structure of a ubia homolog from aeropyrum pernix k1 Phyre2 PDB 3ts7 chain B Region: 59 - 230 Aligned: 169 Modelled: 172 Confidence: 93.6% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of farnesyl diphosphate synthase (target efi-501951)2 from methylococcus capsulatus Phyre2 PDB 3m9u chain D Region: 37 - 230 Aligned: 190 Modelled: 191 Confidence: 92.7% Identity: 13% PDB header:transferase Chain: D: PDB Molecule:farnesyl-diphosphate synthase; PDBTitle: crystal structure of geranylgeranyl pyrophosphate synthase from2 lactobacillus brevis atcc 367 Phyre2 PDB 5xn5 chain A Region: 59 - 226 Aligned: 164 Modelled: 168 Confidence: 91.7% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:os07g0580900 protein; PDBTitle: homo-dimer crystal structure of geranylgeranyl diphosphate synthases 12 from oryza sativa Phyre2 PDB 3dh4 chain A Region: 56 - 243 Aligned: 186 Modelled: 188 Confidence: 80.1% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 3lsn chain A Region: 59 - 230 Aligned: 168 Modelled: 169 Confidence: 70.1% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of putative geranyltranstransferase from pseudomonas2 fluorescens pf-5 complexed with magnesium Phyre2 PDB 4jyx chain E Region: 20 - 93 Aligned: 71 Modelled: 74 Confidence: 59.5% Identity: 14% PDB header:transferase Chain: E: PDB Molecule:trans-hexaprenyltranstransferase; PDBTitle: crystal structure of polyprenyl synthase patl_3739 (target efi-509195)2 from pseudoalteromonas atlantica, complex with inorganic phosphate3 and an unknown ligand Phyre2 PDB 3ez3 chain A Region: 19 - 106 Aligned: 87 Modelled: 88 Confidence: 53.7% Identity: 9% PDB header:lyase Chain: A: PDB Molecule:farnesyl pyrophosphate synthase, putative; PDBTitle: crystal structure of plasmodium vivax geranylgeranylpyrophosphate2 synthase pvx_092040 with zoledronate and ipp bound Phyre2 PDB 1rqj chain A Region: 39 - 226 Aligned: 184 Modelled: 185 Confidence: 52.7% Identity: 13% Fold: Terpenoid synthases Superfamily: Terpenoid synthases Family: Isoprenyl diphosphate synthases Phyre2 PDB 3oac chain D Region: 39 - 230 Aligned: 188 Modelled: 189 Confidence: 51.4% Identity: 10% PDB header:transferase Chain: D: PDB Molecule:geranyl diphosphate synthase large subunit; PDBTitle: mint deletion mutant of heterotetrameric geranyl pyrophosphate2 synthase in complex with ligands Phyre2 PDB 2l4f chain A Region: 71 - 82 Aligned: 12 Modelled: 12 Confidence: 50.7% Identity: 33% PDB header:protein binding Chain: A: PDB Molecule:defective in cullin neddylation protein 1; PDBTitle: nmr structure of the uba domain of s. cerevisiae dcn1 bound to2 ubiquitin Phyre2 PDB 4lfg chain B Region: 38 - 226 Aligned: 185 Modelled: 189 Confidence: 43.1% Identity: 10% PDB header:transferase Chain: B: PDB Molecule:geranylgeranyl diphosphate synthase; PDBTitle: crystal structure of geranylgeranyl diphosphate synthase sub12742 (target efi-509455) from streptococcus uberis 0140j with bound3 magnesium and isopentyl diphosphate, fully liganded complex; Phyre2 PDB 2j1o chain A Region: 157 - 234 Aligned: 74 Modelled: 78 Confidence: 43.1% Identity: 7% PDB header:transferase Chain: A: PDB Molecule:geranylgeranyl pyrophosphate synthetase; PDBTitle: geranylgeranyl diphosphate synthase from sinapis alba Phyre2 PDB 1dih chain A domain 2 Region: 59 - 92 Aligned: 34 Modelled: 34 Confidence: 36.8% Identity: 18% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Dihydrodipicolinate reductase-like Phyre2 PDB 5h9d chain B Region: 37 - 220 Aligned: 178 Modelled: 179 Confidence: 36.1% Identity: 8% PDB header:transferase Chain: B: PDB Molecule:farnesyl pyrophosphate synthetase; PDBTitle: crystal structure of heptaprenyl diphosphate synthase from2 staphylococcus aureus Phyre2 PDB 5us6 chain L Region: 57 - 92 Aligned: 36 Modelled: 36 Confidence: 33.9% Identity: 11% PDB header:oxidoreductase Chain: L: PDB Molecule:4-hydroxy-tetrahydrodipicolinate reductase; PDBTitle: structure of dihydrodipicolinate reductase from vibrio vulnificus2 bound to nadh and 2,6 pyridine dicarboxylic acid with intact3 polyhistidine tag Phyre2 PDB 4ksn chain C Region: 74 - 102 Aligned: 24 Modelled: 29 Confidence: 33.6% Identity: 33% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:sdbc; PDBTitle: c-terminal domain of sdbc protein from legionella pneumophila. Phyre2 PDB 2o1o chain B Region: 35 - 217 Aligned: 178 Modelled: 183 Confidence: 33.0% Identity: 12% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative farnesyl pyrophosphate synthase; PDBTitle: cryptosporidium parvum putative polyprenyl pyrophosphate synthase2 (cgd4_2550) in complex with risedronate. Phyre2 PDB 4kkm chain B Region: 39 - 230 Aligned: 185 Modelled: 192 Confidence: 32.8% Identity: 12% PDB header:transferase Chain: B: PDB Molecule:polyprenyl synthetase; PDBTitle: crystal structure of a fpp/gfpp synthase (target efi-501952) from2 zymomonas mobilis, apo structure Phyre2 PDB 3p8r chain A Region: 19 - 85 Aligned: 63 Modelled: 67 Confidence: 32.8% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:geranyltranstransferase; PDBTitle: crystal structure of polyprenyl synthase from vibrio cholerae Phyre2 1 c4od5C_ 2 c3ts7B_ 3 c3m9uD_ 4 c5xn5A_ 5 c3dh4A_ 6 c3lsnA_ 7 c4jyxE_ 8 c3ez3A_ 9 d1rqja_ 10 c3oacD_ 11 c2l4fA_ 12 c4lfgB_ 13 c2j1oA_ 14 d1diha2 15 c5h9dB_ 16 c5us6L_ 17 c4ksnC_ 18 c2o1oB_ 19 c4kkmB_ 20 c3p8rA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74