1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	Y	D	R	A	V	S	P	S	L	R	V	Q	R	V	I	A	A	I	V	I	L	T	Q	G	G	I	A	V	T	G	A	I	V	R	V	T	A	S	G	L	G	C	P	T	W	P	Q	C	F	P	G	S	F	T	P	V	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	E	V	P	R	V	H	Q	A	V	E	F	G	N	R	M	V	T	F	A	V	V	I	A	A	A	L	A	V	L	V	V	T	R	A	R	R	R	T	E	V	L	A	Y	A	W	L	M	P	V	S	T	V	V	Q	A	M	I	G	G
Secondary structure
SS confidence
Disorder		?		?																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	T	V	R	T	G	L	L	W	W	T	V	A	I	H	L	L	A	S	M	T	M	V	W	L	A	V	L	L	Y	V	K	I	G	Q	P	D	D	G	V	V	H	E	L	V	V	S	P	L	R	A	L	T	A	L	S	A	L	N	L
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	V	L	V	T	G	T	L	V	T	A	A	G	P	H	A	G	D	R	S	P	S	R	T	V	P	R	L	K	V	E	I	T	T	L	V	H	M	H	S	S	L	L	V	A	Y	L	A	L	L	I	G	L	G	F	G	L	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	G	A	T	R	A	I	L	V	R	L	A	V	L	L	A	L	V	A	T	Q	A	A	V	G	T	T	Q	Y	F	T	G	V	P	A	A	L	V	A	I	H	V	A	G	A	A	A	V	T	A	A	T	A	A	L	W	A	S	M	G
Secondary structure
SS confidence
Disorder				?																																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310
Sequence		E	R	A	Q	P	Q	P	L	Q	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 71%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 6ied chain A Region: 8 - 304 Aligned: 291 Modelled: 297 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: A: PDB Molecule:heme a synthase; PDBTitle: crystal structure of heme a synthase from bacillus subtilis Phyre2 PDB 1yp8 chain A Region: 41 - 52 Aligned: 12 Modelled: 12 Confidence: 66.9% Identity: 33% PDB header:cell cycle Chain: A: PDB Molecule:tricyclon a; PDBTitle: solution structure of the cyclotide tricyclon a Phyre2 PDB 5oc0 chain A Region: 94 - 240 Aligned: 147 Modelled: 147 Confidence: 65.5% Identity: 10% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome b561; PDBTitle: structure of e. coli superoxide oxidase Phyre2 PDB 2wan chain A Region: 40 - 55 Aligned: 16 Modelled: 16 Confidence: 55.7% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:pullulanase; PDBTitle: pullulanase from bacillus acidopullulyticus Phyre2 PDB 1nek chain D Region: 72 - 148 Aligned: 77 Modelled: 77 Confidence: 55.1% Identity: 16% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 1wqb chain A Region: 43 - 52 Aligned: 10 Modelled: 10 Confidence: 51.7% Identity: 50% PDB header:toxin Chain: A: PDB Molecule:aptotoxin vii; PDBTitle: three-dimensional solution strucutre of aptotoxin vii, from2 the venom of a trap-door spider Phyre2 PDB 3ghg chain D Region: 43 - 57 Aligned: 15 Modelled: 15 Confidence: 47.4% Identity: 27% PDB header:blood clotting Chain: D: PDB Molecule:fibrinogen alpha chain; PDBTitle: crystal structure of human fibrinogen Phyre2 PDB 2cse chain W Region: 40 - 77 Aligned: 37 Modelled: 38 Confidence: 45.3% Identity: 30% PDB header:virus Chain: W: PDB Molecule:major core protein lambda 1; PDBTitle: features of reovirus outer-capsid protein mu1 revealed by2 electron and image reconstruction of the virion at 7.0-a3 resolution Phyre2 PDB 1k48 chain A Region: 43 - 51 Aligned: 9 Modelled: 9 Confidence: 43.9% Identity: 56% PDB header:plant protein Chain: A: PDB Molecule:kalata b1; PDBTitle: refined structure and disulfide pairing of the kalata b12 peptide Phyre2 PDB 1jjz chain A Region: 43 - 51 Aligned: 9 Modelled: 9 Confidence: 43.7% Identity: 56% PDB header:plant protein Chain: A: PDB Molecule:kalata b1; PDBTitle: refined structure and disulfide pairing of the kalata b12 peptide Phyre2 PDB 3k1q chain C Region: 40 - 77 Aligned: 37 Modelled: 0 Confidence: 39.3% Identity: 19% PDB header: PDB COMPND: Phyre2 PDB 3k1q chain B Region: 40 - 77 Aligned: 37 Modelled: 0 Confidence: 39.0% Identity: 19% PDB header: PDB COMPND: Phyre2 PDB 6fo2 chain R Region: 42 - 55 Aligned: 13 Modelled: 14 Confidence: 38.3% Identity: 46% PDB header:membrane protein Chain: R: PDB Molecule:cytochrome b-c1 complex subunit rieske, mitochondrial; PDBTitle: cryoem structure of bovine cytochrome bc1 with no ligand bound Phyre2 PDB 1n1u chain A Region: 41 - 56 Aligned: 15 Modelled: 16 Confidence: 35.4% Identity: 33% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Cyclotides Family: Kalata B1 Phyre2 PDB 1n1u chain A Region: 41 - 56 Aligned: 15 Modelled: 16 Confidence: 35.4% Identity: 33% PDB header:antibiotic Chain: A: PDB Molecule:kalata b1; PDBTitle: nmr structure of [ala1,15]kalata b1 Phyre2 PDB 2kuk chain A Region: 41 - 56 Aligned: 16 Modelled: 16 Confidence: 32.4% Identity: 31% PDB header:antiviral protein Chain: A: PDB Molecule:leaf cyclotide 2; PDBTitle: solution structure of vhl-2 Phyre2 PDB 1ma3 chain A Region: 37 - 75 Aligned: 38 Modelled: 39 Confidence: 32.1% Identity: 13% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Sir2 family of transcriptional regulators Phyre2 PDB 2a45 chain J Region: 43 - 57 Aligned: 15 Modelled: 15 Confidence: 29.2% Identity: 27% PDB header:hydrolase/hydrolase inhibitor Chain: J: PDB Molecule:fibrinogen alpha chain; PDBTitle: crystal structure of the complex between thrombin and the central "e"2 region of fibrin Phyre2 PDB 4ttn chain A Region: 43 - 50 Aligned: 8 Modelled: 8 Confidence: 28.1% Identity: 63% PDB header:plant protein Chain: A: PDB Molecule:kalata-b1; PDBTitle: quasi-racemic structure of [g6a]kalata b1 Phyre2 PDB 3cwb chain C Region: 161 - 310 Aligned: 150 Modelled: 150 Confidence: 27.9% Identity: 16% PDB header:oxidoreductase Chain: C: PDB Molecule:cytochrome b; PDBTitle: chicken cytochrome bc1 complex inhibited by an iodinated analogue of2 the polyketide crocacin-d Phyre2 1 c6iedA_ 2 c1yp8A_ 3 c5oc0A_ 4 c2wanA_ 5 d1nekd_ 6 c1wqbA_ 7 c3ghgD_ 8 c2cseW_ 9 c1k48A_ 10 c1jjzA_ 11 c3k1qC_ 12 c3k1qB_ 13 c6fo2R_ 14 d1n1ua_ 15 c1n1uA_ 16 c2kukA_ 17 d1ma3a_ 18 c2a45J_ 19 c4ttnA_ 20 c3cwbC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99