1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	Q	T	N	R	P	A	F	P	A	G	T	F	S	P	D	P	R	P	N	A	V	P	L	M	L	A	A	Q	F	S	L	E	L	K	L	L	L	R	N	G	E	Q	L	L	L	T	M	F	I	P	I	T	L	L	V	G	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	P	M	G	S	F	G	H	N	R	A	A	T	F	V	P	V	I	M	A	L	A	V	I	S	T	A	F	T	G	Q	A	I	A	V	A	F	D	R	R	Y	G	A	L	K	R	L	G	A	T	P	L	P	V	W	G	I	I	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	K	S	L	A	V	V	A	V	V	F	L	Q	A	I	I	L	G	A	I	G	F	A	L	G	W	R	P	A	L	T	A	L	T	L	G	A	G	I	I	A	L	G	T	A	G	F	A	A	L	G	L	L	L	G	G	T	L	R	A
Secondary structure
SS confidence
Disorder																																																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	I	V	L	A	V	A	N	L	M	W	F	V	F	A	G	F	G	A	L	T	L	E	S	N	V	I	P	T	A	F	K	W	V	A	R	V	T	P	S	G	A	L	T	E	A	L	S	Q	A	M	T	V	S	V	D	W	F	G	I
Secondary structure
SS confidence
Disorder																				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.
Sequence		V	V	L	A	V	W	G	A	L	A	A	L	A	A	L	R	W	F	R	F	T
Secondary structure
SS confidence
Disorder																				?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 48%) (View membrane topology prediction)

Rank Aligned region

PDB 6an7 chain D Region: 25 - 259 Aligned: 230 Modelled: 235 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: D: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 6an7 chain C Region: 24 - 259 Aligned: 231 Modelled: 236 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: C: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 5nj3 chain B Region: 19 - 260 Aligned: 242 Modelled: 242 Confidence: 99.9% Identity: 16% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: complete structure Phyre2 PDB 5do7 chain B Region: 21 - 260 Aligned: 240 Modelled: 240 Confidence: 99.9% Identity: 13% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 8; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5do7 chain A Region: 7 - 260 Aligned: 254 Modelled: 254 Confidence: 99.9% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family g member 5; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5njg chain B Region: 22 - 260 Aligned: 239 Modelled: 239 Confidence: 99.9% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: part of the structure that could be2 built de novo Phyre2 PDB 5xjy chain A Region: 70 - 257 Aligned: 187 Modelled: 188 Confidence: 98.4% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family a member 1; PDBTitle: cryo-em structure of human abca1 Phyre2 PDB 1ifl chain A Region: 220 - 259 Aligned: 40 Modelled: 40 Confidence: 61.7% Identity: 23% PDB header:virus Chain: A: PDB Molecule:inovirus; PDBTitle: molecular models and structural comparisons of native and2 mutant class i filamentous bacteriophages ff (fd, f1, m13),3 if1 and ike Phyre2 PDB 2jra chain B Region: 1 - 22 Aligned: 22 Modelled: 22 Confidence: 17.9% Identity: 14% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein rpa2121; PDBTitle: a novel domain-swapped solution nmr structure of protein rpa2121 from2 rhodopseudomonas palustris. northeast structural genomics target rpt6 Phyre2 PDB 2lly chain A Region: 40 - 92 Aligned: 53 Modelled: 53 Confidence: 15.6% Identity: 21% PDB header:transport protein Chain: A: PDB Molecule:neuronal acetylcholine receptor subunit alpha-4; PDBTitle: nmr structures of the transmembrane domains of the nachr a4 subunit Phyre2 PDB 6d6t chain E Region: 40 - 96 Aligned: 57 Modelled: 57 Confidence: 13.5% Identity: 19% PDB header:transport protein Chain: E: PDB Molecule:human gaba-a receptor subunit gamma-2; PDBTitle: human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba2 and flumazenil, conformation b Phyre2 PDB 3jad chain C Region: 40 - 137 Aligned: 87 Modelled: 98 Confidence: 10.0% Identity: 20% PDB header:signaling protein/antagonist Chain: C: PDB Molecule:glycine receptor subunit alphaz1; PDBTitle: structure of alpha-1 glycine receptor by single particle electron2 cryo-microscopy, strychnine-bound state Phyre2 PDB 3ria chain C Region: 40 - 138 Aligned: 88 Modelled: 99 Confidence: 6.1% Identity: 14% PDB header:transport protein/immune system Chain: C: PDB Molecule:avermectin-sensitive glutamate-gated chloride channel glucl PDBTitle: c. elegans glutamate-gated chloride channel (glucl) in complex with2 fab, ivermectin and iodide. Phyre2 PDB 2m6i chain C Region: 40 - 87 Aligned: 48 Modelled: 48 Confidence: 6.1% Identity: 21% PDB header:membrane protein Chain: C: PDB Molecule:full-length transmembrane domains of human glycine receptor PDBTitle: putative pentameric open-channel structure of full-length2 transmembrane domains of human glycine receptor alpha1 subunit Phyre2 1 c6an7D_ 2 c6an7C_ 3 c5nj3B_ 4 c5do7B_ 5 c5do7A_ 6 c5njgB_ 7 c5xjyA_ 8 c1iflA_ 9 c2jraB_ 10 c2llyA_ 11 c6d6tE_ 12 c3jadC_ 13 c3riaC_ 14 c2m6iC_