1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	A	R	H	H	T	L	S	W	S	I	A	S	L	H	G	D	E	Q	A	V	G	A	P	L	T	T	T	E	L	T	A	L	A	R	T	R	L	F	G	A	T	G	T	V	L	M	A	I	G	A	L	G	A	G	A	R	P	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																	?	?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	Q	D	P	T	F	G	V	R	L	L	N	L	P	S	R	I	Q	T	V	S	L	T	M	T	T	T	G	A	V	M	M	A	L	A	W	L	M	L	G	R	F	T	L	G	R	R	R	M	S	R	G	K	L	D	R	T	L	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?			?	?	?	?	?	?	?		?		?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		W	M	L	P	L	L	I	A	P	P	M	Y	S	K	D	V	Y	S	Y	L	A	Q	S	E	I	G	R	D	G	L	D	P	Y	R	V	G	P	A	S	G	L	G	L	G	H	V	F	T	L	S	V	P	S	L	W	R	E	T	P	A
Secondary structure
SS confidence
Disorder																																							?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	Y	G	P	L	F	L	W	I	G	R	G	I	S	S	L	T	G	E	N	I	V	A	A	V	L	C	H	R	L	V	V	L	I	G	V	T	L	I	V	W	A	T	P	R	L	A	Q	R	C	G	V	A	E	V	S	A	L	W	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	A	A	N	P	L	L	I	M	H	L	V	A	G	I	H	N	E	A	L	M	L	G	L	M	L	T	G	V	E	F	A	L	R	G	L	D	M	A	N	T	P	R	P	S	P	E	T	W	R	L	G	P	A	T	I	R	A	S	R
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	P	E	L	G	A	S	P	R	A	G	A	S	R	A	V	K	P	R	P	E	W	G	P	L	A	M	L	L	A	G	S	I	L	I	T	L	S	S	Q	V	K	L	P	S	L	L	A	M	G	F	V	T	T	V	L	A	Y	R	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	G	N	L	R	A	L	L	L	A	A	A	V	M	A	S	L	T	L	A	I	M	A	I	L	G	W	A	S	G	L	G	F	G	W	I	N	T	L	G	T	A	N	V	V	R	S	W	M	S	P	P	T	L	L	A	L	G	T	G
Secondary structure
SS confidence
Disorder																													?																?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		H	V	G	I	L	L	G	L	G	D	H	T	T	A	V	L	S	L	T	R	A	I	G	V	L	I	I	T	V	M	V	C	W	L	L	L	A	V	L	R	G	R	L	H	P	I	G	G	L	G	V	A	L	A	V	T	V	L	L	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		P	V	V	Q	P	W	Y	L	L	W	A	I	I	P	L	A	A	W	A	T	R	P	G	F	R	V	A	A	I	L	A	T	L	I	V	G	I	F	G	P	T	A	N	G	D	R	F	A	L	F	Q	I	V	D	A	T	A	A	S	A
Secondary structure
SS confidence
Disorder																					?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.
Sequence		I	I	V	I	L	L	I	A	L	T	Y	T	R	L	P	W	R	P	L	A	A	E	Q	V	V	T	A	A	E	S	A	S	K	T	P	A	T	R	R	P	T	A	A	P	D	A	Y	A	D	S	T
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 66%) Beta strand ( 0%) TM helix ( 53%) (View membrane topology prediction)

Rank Aligned region

PDB 5f15 chain A Region: 114 - 548 Aligned: 353 Modelled: 358 Confidence: 99.0% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:4-amino-4-deoxy-l-arabinose (l-ara4n) transferase; PDBTitle: crystal structure of arnt from cupriavidus metallidurans bound to2 undecaprenyl phosphate Phyre2 PDB 6p25 chain A Region: 181 - 411 Aligned: 190 Modelled: 192 Confidence: 98.4% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 1; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor and a peptide acceptor Phyre2 PDB 6p2r chain B Region: 110 - 411 Aligned: 236 Modelled: 239 Confidence: 98.1% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:dolichyl-phosphate-mannose--protein mannosyltransferase 2; PDBTitle: structure of s. cerevisiae protein o-mannosyltransferase pmt1-pmt22 complex bound to the sugar donor Phyre2 PDB 3waj chain A Region: 131 - 516 Aligned: 337 Modelled: 350 Confidence: 97.8% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:transmembrane oligosaccharyl transferase; PDBTitle: crystal structure of the archaeoglobus fulgidus2 oligosaccharyltransferase (o29867_arcfu) complex with zn and sulfate Phyre2 PDB 3rce chain A Region: 130 - 522 Aligned: 341 Modelled: 349 Confidence: 96.9% Identity: 11% PDB header:transferase/peptide Chain: A: PDB Molecule:oligosaccharide transferase to n-glycosylate proteins; PDBTitle: bacterial oligosaccharyltransferase pglb Phyre2 PDB 2kfv chain A Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 36.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:fk506-binding protein 3; PDBTitle: structure of the amino-terminal domain of human fk506-2 binding protein 3 / northeast structural genomics3 consortium target ht99a Phyre2 PDB 6adq chain P Region: 496 - 558 Aligned: 63 Modelled: 63 Confidence: 30.6% Identity: 14% PDB header:electron transport Chain: P: PDB Molecule:prokaryotic respiratory supercomplex associate factor 1 PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 1ynj chain D domain 1 Region: 480 - 488 Aligned: 9 Modelled: 9 Confidence: 30.2% Identity: 22% Fold: beta and beta-prime subunits of DNA dependent RNA-polymerase Superfamily: beta and beta-prime subunits of DNA dependent RNA-polymerase Family: RNA-polymerase beta-prime Phyre2 PDB 5ir6 chain A Region: 83 - 229 Aligned: 104 Modelled: 121 Confidence: 26.7% Identity: 23% PDB header:oxidoreductase Chain: A: PDB Molecule:bd-type quinol oxidase subunit i; PDBTitle: the structure of bd oxidase from geobacillus thermodenitrificans Phyre2 PDB 2r6g chain F domain 1 Region: 438 - 535 Aligned: 92 Modelled: 98 Confidence: 25.9% Identity: 7% Fold: MalF N-terminal region-like Superfamily: MalF N-terminal region-like Family: MalF N-terminal region-like Phyre2 PDB 4g7o chain N Region: 481 - 488 Aligned: 8 Modelled: 8 Confidence: 25.5% Identity: 25% PDB header:transcription, transferase/dna Chain: N: PDB Molecule:dna-directed rna polymerase subunit beta'; PDBTitle: crystal structure of thermus thermophilus transcription initiation2 complex containing 2 nt of rna Phyre2 PDB 5xj0 chain D Region: 481 - 488 Aligned: 8 Modelled: 8 Confidence: 24.8% Identity: 25% PDB header:transferase/transcription Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta'; PDBTitle: t. thermophilus rna polymerase holoenzyme bound with gp39 and gp76 Phyre2 PDB 5x22 chain D Region: 481 - 488 Aligned: 8 Modelled: 8 Confidence: 18.9% Identity: 25% PDB header:transferase/dna Chain: D: PDB Molecule:dna-directed rna polymerase subunit beta'; PDBTitle: crystal structure of thermus thermophilus transcription initiation2 complex with gpa and cmpcpp Phyre2 PDB 1zxo chain A domain 1 Region: 148 - 160 Aligned: 13 Modelled: 13 Confidence: 18.5% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: BadF/BadG/BcrA/BcrD-like Phyre2 PDB 2e74 chain B domain 1 Region: 485 - 552 Aligned: 68 Modelled: 68 Confidence: 16.7% Identity: 16% Fold: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Superfamily: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Family: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 PDB 1zbs chain A domain 2 Region: 148 - 160 Aligned: 13 Modelled: 13 Confidence: 15.8% Identity: 15% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: BadF/BadG/BcrA/BcrD-like Phyre2 PDB 1vf5 chain B Region: 485 - 551 Aligned: 67 Modelled: 67 Confidence: 15.2% Identity: 16% Fold: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Superfamily: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Family: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 PDB 1q90 chain D Region: 485 - 552 Aligned: 68 Modelled: 68 Confidence: 12.8% Identity: 10% Fold: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Superfamily: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Family: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 PDB 1r9f chain A Region: 5 - 53 Aligned: 48 Modelled: 49 Confidence: 11.5% Identity: 25% Fold: Tombusvirus P19 core protein, VP19 Superfamily: Tombusvirus P19 core protein, VP19 Family: Tombusvirus P19 core protein, VP19 Phyre2 PDB 3e1k chain J Region: 134 - 144 Aligned: 11 Modelled: 7 Confidence: 11.5% Identity: 36% PDB header:transcription Chain: J: PDB Molecule:lactose regulatory protein lac9; PDBTitle: crystal structure of kluyveromyces lactis gal80p in complex with the2 acidic activation domain of gal4p Phyre2 1 c5f15A_ 2 c6p25A_ 3 c6p2rB_ 4 c3wajA_ 5 c3rceA_ 6 c2kfvA_ 7 c6adqP_ 8 d1ynjd1 9 c5ir6A_ 10 d2r6gf1 11 c4g7oN_ 12 c5xj0D_ 13 c5x22D_ 14 d1zxoa1 15 d2e74b1 16 d1zbsa2 17 d1vf5b_ 18 d1q90d_ 19 d1r9fa_ 20 c3e1kJ_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61