1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	E	S	K	A	P	A	V	V	H	P	P	S	M	L	R	G	D	I	D	D	P	K	L	A	A	A	L	R	T	L	E	L	T	V	K	Q	K	L	D	G	V	L	H	G	D	H	L	G	L	I	P	G	P	G	S	E	P	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?		?	?		?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	S	R	L	Y	Q	P	G	D	D	V	R	R	M	D	W	A	V	T	A	R	T	T	H	P	H	V	R	Q	M	I	A	D	R	E	L	E	T	W	L	V	V	D	M	S	A	S	L	D	F	G	T	A	C	C	E	K	R	D	L
Secondary structure
SS confidence
Disorder																																																?		?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	V	A	A	A	A	A	I	T	F	L	N	S	G	G	G	N	R	L	G	A	L	I	A	N	G	A	A	M	T	R	V	P	A	R	T	G	R	Q	H	Q	H	T	M	L	R	T	I	A	T	M	P	Q	A	P	A	G	V	R	G
Secondary structure
SS confidence
Disorder																																																							?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	L	A	V	A	I	D	A	L	R	R	P	E	R	R	R	G	M	A	V	I	I	S	D	F	L	G	P	I	N	W	M	R	P	L	R	A	I	A	A	R	H	E	V	L	A	I	E	V	L	D	P	R	D	V	E	L	P	D	V
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	D	V	V	L	Q	D	A	E	S	G	V	V	R	E	F	S	I	D	P	A	L	R	D	D	F	A	R	A	A	A	A	H	R	A	D	V	A	R	T	I	R	G	C	G	A	P	L	L	S	L	R	T	D	R	D	W	L	A	D
Secondary structure
SS confidence
Disorder																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.
Sequence		I	V	R	F	V	A	S	R	R	R	G	A	L	A	G	H	Q
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 37%) Beta strand ( 18%)

Rank Aligned region

PDB 3ibs chain A Region: 94 - 310 Aligned: 199 Modelled: 200 Confidence: 99.2% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein batb; PDBTitle: crystal structure of conserved hypothetical protein batb from2 bacteroides thetaiotaomicron Phyre2 PDB 4fx5 chain A Region: 94 - 307 Aligned: 168 Modelled: 173 Confidence: 99.1% Identity: 13% PDB header:blood clotting Chain: A: PDB Molecule:von willebrand factor type a; PDBTitle: von willebrand factor type a from catenulispora acidiphila Phyre2 PDB 6nmi chain E Region: 96 - 304 Aligned: 166 Modelled: 168 Confidence: 98.9% Identity: 13% PDB header:transcription Chain: E: PDB Molecule:general transcription factor iih subunit 2, p44; PDBTitle: cryo-em structure of the human tfiih core complex Phyre2 PDB 6fpz chain A Region: 97 - 307 Aligned: 163 Modelled: 172 Confidence: 98.9% Identity: 10% PDB header:structural protein Chain: A: PDB Molecule:inter-alpha-trypsin inhibitor heavy chain h1; PDBTitle: inter-alpha-inhibitor heavy chain 1, d298a Phyre2 PDB 6o9l chain 6 Region: 96 - 305 Aligned: 167 Modelled: 169 Confidence: 98.8% Identity: 14% PDB header:transcription/dna Chain: 6: PDB Molecule:general transcription factor iih subunit 2; PDBTitle: human holo-pic in the closed state Phyre2 PDB 5oqj chain 6 Region: 96 - 233 Aligned: 135 Modelled: 138 Confidence: 98.6% Identity: 14% PDB header:transcription Chain: 6: PDB Molecule:suppressor of stem-loop protein 1; PDBTitle: structure of yeast transcription pre-initiation complex with tfiih Phyre2 PDB 4rck chain B Region: 96 - 304 Aligned: 183 Modelled: 183 Confidence: 98.6% Identity: 16% PDB header:membrane protein Chain: B: PDB Molecule:hypothetical membrane spanning protein; PDBTitle: crystal structure of uncharacterized membrane spanning protein from2 vibrio fischeri Phyre2 PDB 2nvo chain A Region: 92 - 229 Aligned: 132 Modelled: 138 Confidence: 98.6% Identity: 15% PDB header:rna binding protein Chain: A: PDB Molecule:ro sixty-related protein, rsr; PDBTitle: crystal structure of deinococcus radiodurans ro (rsr) protein Phyre2 PDB 1yvr chain A domain 2 Region: 92 - 229 Aligned: 129 Modelled: 136 Confidence: 98.5% Identity: 13% Fold: vWA-like Superfamily: vWA-like Family: RoRNP C-terminal domain-like Phyre2 PDB 5a8j chain A Region: 94 - 229 Aligned: 122 Modelled: 136 Confidence: 98.4% Identity: 16% PDB header:transcription Chain: A: PDB Molecule:vwa2; PDBTitle: crystal structure of the arnb paralog vwa2 from2 sulfolobus acidocaldarius Phyre2 PDB 4b4t chain W Region: 98 - 229 Aligned: 126 Modelled: 132 Confidence: 98.4% Identity: 16% PDB header:hydrolase Chain: W: PDB Molecule:26s proteasome regulatory subunit rpn10; PDBTitle: near-atomic resolution structural model of the yeast 26s proteasome Phyre2 PDB 4wfq chain A Region: 96 - 229 Aligned: 132 Modelled: 134 Confidence: 98.4% Identity: 11% PDB header:transcription Chain: A: PDB Molecule:suppressor of stem-loop protein 1; PDBTitle: crystal structure of tfiih subunit Phyre2 PDB 2x31 chain F Region: 91 - 229 Aligned: 126 Modelled: 139 Confidence: 98.4% Identity: 14% PDB header:ligase Chain: F: PDB Molecule:magnesium-chelatase 60 kda subunit; PDBTitle: modelling of the complex between subunits bchi and bchd of magnesium2 chelatase based on single-particle cryo-em reconstruction at 7.5 ang Phyre2 PDB 5gjq chain W Region: 97 - 229 Aligned: 127 Modelled: 127 Confidence: 98.3% Identity: 13% PDB header:hydrolase Chain: W: PDB Molecule:26s proteasome non-atpase regulatory subunit 4; PDBTitle: structure of the human 26s proteasome bound to usp14-ubal Phyre2 PDB 5iy7 chain 0 Region: 96 - 305 Aligned: 167 Modelled: 169 Confidence: 98.3% Identity: 16% PDB header:transcription, transferase/dna Chain: 0: PDB Molecule:general transcription factor iih subunit 2; PDBTitle: human holo-pic in the open state Phyre2 PDB 1jey chain B domain 2 Region: 98 - 239 Aligned: 142 Modelled: 142 Confidence: 98.3% Identity: 9% Fold: vWA-like Superfamily: vWA-like Family: Ku80 subunit N-terminal domain Phyre2 PDB 2x5n chain A Region: 97 - 229 Aligned: 128 Modelled: 133 Confidence: 98.3% Identity: 14% PDB header:nuclear protein Chain: A: PDB Molecule:26s proteasome regulatory subunit rpn10; PDBTitle: crystal structure of the sprpn10 vwa domain Phyre2 PDB 1rs0 chain A Region: 95 - 208 Aligned: 109 Modelled: 114 Confidence: 98.2% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: crystal structure analysis of the bb segment of factor b2 complexed with di-isopropyl-phosphate (dip) Phyre2 PDB 1jey chain A domain 2 Region: 98 - 237 Aligned: 140 Modelled: 140 Confidence: 98.2% Identity: 9% Fold: vWA-like Superfamily: vWA-like Family: Ku70 subunit N-terminal domain Phyre2 PDB 2i6s chain A Region: 89 - 207 Aligned: 113 Modelled: 114 Confidence: 98.1% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:complement c2a fragment; PDBTitle: complement component c2a Phyre2 1 c3ibsA_ 2 c4fx5A_ 3 c6nmiE_ 4 c6fpzA_ 5 c6o9l6_ 6 c5oqj6_ 7 c4rckB_ 8 c2nvoA_ 9 d1yvra2 10 c5a8jA_ 11 c4b4tW_ 12 c4wfqA_ 13 c2x31F_ 14 c5gjqW_ 15 c5iy70_ 16 d1jeyb2 17 c2x5nA_ 18 c1rs0A_ 19 d1jeya2 20 c2i6sA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99