1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	D	P	F	L	G	S	E	A	L	A	A	G	V	L	T	P	Y	E	L	R	S	R	Y	V	A	L	H	K	D	V	Y	V	P	Q	G	V	E	L	T	A	Q	L	R	A	K	A	L	W	L	R	S	R	R	R	G	V	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	Y	S	A	S	A	F	H	G	A	K	W	I	D	A	D	L	P	A	A	I	I	D	T	N	R	R	R	A	P	G	L	Q	V	W	E	E	R	I	E	P	D	E	I	C	V	I	E	G	M	R	V	T	T	P	E	R	T	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	L	T	S	R	F	P	L	D	P	A	V	A	A	V	D	A	L	I	Q	A	T	D	L	K	V	A	D	V	E	P	L	I	E	R	Y	R	G	R	R	G	M	K	A	A	R	A	A	L	D	L	V	D	G	G	A	Q	S	P	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		E	T	W	L	R	L	L	L	I	R	A	G	F	P	R	P	Q	T	Q	I	A	V	R	N	E	W	G	W	A	E	A	H	L	D	M	G	W	Q	D	I	K	V	A	A	E	Y	D	G	D	H	H	L	T	S	R	Y	H	Y	R	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence		D	I	L	R	H	E	K	V	Q	H	R	Y	G	W	I	V	V	R	V	V	A	E	D	H	P	A	D	I	I	R	R	V	G	E	A	R	A	F	R	A
Secondary structure
SS confidence
Disorder																																						?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 4%) Alpha helix ( 44%) Beta strand ( 21%)

Rank Aligned region

PDB 3r3p chain B Region: 177 - 277 Aligned: 92 Modelled: 101 Confidence: 99.5% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:mobile intron protein; PDBTitle: homing endonuclease i-bth0305i catalytic domain Phyre2 PDB 3hrl chain A Region: 176 - 279 Aligned: 87 Modelled: 104 Confidence: 99.1% Identity: 20% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:endonuclease-like protein; PDBTitle: crystal structure of a putative endonuclease-like protein (ngo0050)2 from neisseria gonorrhoeae Phyre2 PDB 1cw0 chain A Region: 175 - 277 Aligned: 95 Modelled: 103 Confidence: 99.0% Identity: 18% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 1vsr chain A Region: 181 - 259 Aligned: 71 Modelled: 79 Confidence: 97.5% Identity: 23% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Very short patch repair (VSR) endonuclease Phyre2 PDB 4oq2 chain A Region: 196 - 278 Aligned: 82 Modelled: 83 Confidence: 96.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:restriction endonuclease pvurts1 i; PDBTitle: 5hmc specific restriction endonuclease pvurts1i Phyre2 PDB 4par chain C Region: 196 - 279 Aligned: 82 Modelled: 84 Confidence: 96.0% Identity: 26% PDB header:dna binding protein/dna Chain: C: PDB Molecule:uncharacterized protein abasi; PDBTitle: the 5-hydroxymethylcytosine-specific restriction enzyme abasi in a2 complex with product-like dna Phyre2 PDB 6rdu chain 2 Region: 204 - 280 Aligned: 77 Modelled: 77 Confidence: 94.8% Identity: 17% PDB header:proton transport Chain: 2: PDB Molecule:asa-2: polytomella f-atp synthase associated subunit 2; PDBTitle: cryo-em structure of polytomella f-atp synthase, rotary substate 1e,2 monomer-masked refinement Phyre2 PDB 1m0d chain A Region: 178 - 229 Aligned: 51 Modelled: 52 Confidence: 88.8% Identity: 14% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Endonuclease I (Holliday junction resolvase) Phyre2 PDB 1zel chain A domain 2 Region: 55 - 208 Aligned: 144 Modelled: 154 Confidence: 83.0% Identity: 19% Fold: Rv2827c C-terminal domain-like Superfamily: Rv2827c C-terminal domain-like Family: Rv2827c C-terminal domain-like Phyre2 PDB 1zel chain A Region: 8 - 208 Aligned: 188 Modelled: 201 Confidence: 76.8% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein rv2827c; PDBTitle: crystal structure of rv2827c protein from mycobacterium tuberculosis Phyre2 PDB 2fcl chain A domain 1 Region: 56 - 81 Aligned: 26 Modelled: 26 Confidence: 47.6% Identity: 19% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: TM1012-like Phyre2 PDB 2iea chain A domain 2 Region: 217 - 271 Aligned: 55 Modelled: 55 Confidence: 35.3% Identity: 15% Fold: Thiamin diphosphate-binding fold (THDP-binding) Superfamily: Thiamin diphosphate-binding fold (THDP-binding) Family: TK-like PP module Phyre2 PDB 4gqz chain B Region: 193 - 229 Aligned: 37 Modelled: 36 Confidence: 31.5% Identity: 16% PDB header:metal binding protein Chain: B: PDB Molecule:putative periplasmic or exported protein; PDBTitle: crystal structure of s.cuep Phyre2 PDB 4ytk chain A Region: 23 - 33 Aligned: 11 Modelled: 11 Confidence: 21.5% Identity: 27% PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt5; PDBTitle: structure of the kow1-linker1 domain of transcription elongation2 factor spt5 Phyre2 PDB 3wbz chain D Region: 214 - 232 Aligned: 19 Modelled: 19 Confidence: 16.1% Identity: 16% PDB header:transferase Chain: D: PDB Molecule:likely histidyl trna-specific guanylyltransferase; PDBTitle: crystal structure of c. albicans trna(his) guanylyltransferase (thg1)2 with atp Phyre2 PDB 5xox chain D Region: 214 - 232 Aligned: 19 Modelled: 19 Confidence: 15.9% Identity: 16% PDB header:transferase Chain: D: PDB Molecule:trna(his) guanylyltransferase; PDBTitle: crystal structure of trna(his) guanylyltranserase from saccharomyces2 cerevisiae Phyre2 PDB 3otb chain B Region: 214 - 232 Aligned: 19 Modelled: 19 Confidence: 15.0% Identity: 21% PDB header:transferase Chain: B: PDB Molecule:trna(his) guanylyltransferase; PDBTitle: crystal structure of human trnahis guanylyltransferase (thg1) - dgtp2 complex Phyre2 PDB 4kgk chain B Region: 216 - 232 Aligned: 17 Modelled: 17 Confidence: 12.1% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:thg1-like uncharacterized protein; PDBTitle: bacterial trna(his) guanylyltransferase (thg1)-like protein in complex2 with gtp Phyre2 PDB 2fuk chain A domain 1 Region: 192 - 259 Aligned: 67 Modelled: 68 Confidence: 7.8% Identity: 16% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Atu1826-like Phyre2 PDB 5n35 chain A Region: 178 - 197 Aligned: 20 Modelled: 20 Confidence: 7.0% Identity: 30% PDB header:polymerase binding protein Chain: A: PDB Molecule:polb1 binding protein 2 (pbp2); PDBTitle: gadolinium phased pbp2 (sso6202) at 2.2 ang Phyre2 1 c3r3pB_ 2 c3hrlA_ 3 d1cw0a_ 4 d1vsra_ 5 c4oq2A_ 6 c4parC_ 7 c6rdu2_ 8 d1m0da_ 9 d1zela2 10 c1zelA_ 11 d2fcla1 12 d2ieaa2 13 c4gqzB_ 14 c4ytkA_ 15 c3wbzD_ 16 c5xoxD_ 17 c3otbB_ 18 c4kgkB_ 19 d2fuka1 20 c5n35A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40