1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	G	L	T	S	P	K	T	Y	A	V	L	A	A	L	Q	A	G	D	A	V	A	C	A	I	P	L	P	P	I	A	R	L	L	D	D	L	D	V	P	V	S	V	R	P	V	L	P	V	V	K	A	A	S	A	V	G	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.
Sequence		S	V	T	R	F	P	A	L	A	R	L	T	T	A	M	L	T	L	Y	F	I	L	A	V	G	A	H	V	R	V	R	D	R	V	V	N	A	I	P	A	A	S	F	L	T	L	F	A	L	M	T	A	K	G	P	E	R	T
Secondary structure
SS confidence
Disorder																																																					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 84%) Beta strand ( 0%) TM helix ( 45%) (View membrane topology prediction)

Rank Aligned region

PDB 6hwh chain X Region: 41 - 78 Aligned: 38 Modelled: 38 Confidence: 24.9% Identity: 18% PDB header:electron transport Chain: X: PDB Molecule:cytochrome c oxidase polypeptide 4; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 2l35 chain B Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 19.4% Identity: 24% PDB header:protein binding Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12-nkg2c transmembrane heterotrimer Phyre2 PDB 4wo1 chain D Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 18.5% Identity: 24% PDB header:signaling protein Chain: D: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipid cubic2 phase Phyre2 PDB 4wo1 chain B Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 18.5% Identity: 24% PDB header:signaling protein Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipid cubic2 phase Phyre2 PDB 4wo1 chain C Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 18.5% Identity: 24% PDB header:signaling protein Chain: C: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipid cubic2 phase Phyre2 PDB 4wo1 chain A Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 18.5% Identity: 24% PDB header:signaling protein Chain: A: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipid cubic2 phase Phyre2 PDB 4wol chain A Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 18.3% Identity: 24% PDB header:signaling protein Chain: A: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipidic cubic2 phase Phyre2 PDB 2l34 chain A Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 18.3% Identity: 24% PDB header:protein binding Chain: A: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12 transmembrane homodimer Phyre2 PDB 2l34 chain B Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 18.3% Identity: 24% PDB header:protein binding Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12 transmembrane homodimer Phyre2 PDB 4wol chain C Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 17.7% Identity: 24% PDB header:signaling protein Chain: C: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipidic cubic2 phase Phyre2 PDB 4wol chain B Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 17.7% Identity: 24% PDB header:signaling protein Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: crystal structure of the dap12 transmembrane domain in lipidic cubic2 phase Phyre2 PDB 2rg8 chain A Region: 3 - 39 Aligned: 37 Modelled: 37 Confidence: 11.1% Identity: 14% PDB header:apoptosis, translation Chain: A: PDB Molecule:programmed cell death protein 4; PDBTitle: crystal structure of programmed for cell death 4 middle ma3 domain Phyre2 PDB 2lop chain A Region: 95 - 113 Aligned: 19 Modelled: 19 Confidence: 10.8% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:transmembrane protein 14a; PDBTitle: backbone structure of human membrane protein tmem14a Phyre2 PDB 2kzt chain A Region: 3 - 43 Aligned: 41 Modelled: 41 Confidence: 9.2% Identity: 12% PDB header:apoptosis Chain: A: PDB Molecule:programmed cell death protein 4; PDBTitle: structure of the tandem ma-3 region of pdcd4 Phyre2 PDB 6hlt chain D Region: 27 - 42 Aligned: 16 Modelled: 16 Confidence: 8.5% Identity: 31% PDB header:viral protein Chain: D: PDB Molecule:genome polyprotein; PDBTitle: crystal structure of human acbd3 gold domain in complex with 3a2 protein of rhinovirus-14 (hrv14) Phyre2 PDB 2los chain A Region: 53 - 113 Aligned: 60 Modelled: 61 Confidence: 8.3% Identity: 20% PDB header:membrane protein Chain: A: PDB Molecule:transmembrane protein 14c; PDBTitle: backbone structure of human membrane protein tmem14c Phyre2 PDB 2l35 chain A Region: 58 - 82 Aligned: 25 Modelled: 25 Confidence: 7.7% Identity: 24% PDB header:protein binding Chain: A: PDB Molecule:dap12-nkg2c_tm; PDBTitle: structure of the dap12-nkg2c transmembrane heterotrimer Phyre2 PDB 2mgy chain A Region: 40 - 112 Aligned: 73 Modelled: 73 Confidence: 7.7% Identity: 22% PDB header:membrane protein Chain: A: PDB Molecule:translocator protein; PDBTitle: solution structure of the mitochondrial translocator protein (tspo) in2 complex with its high-affinity ligand pk11195 Phyre2 PDB 2lz4 chain A Region: 58 - 81 Aligned: 24 Modelled: 24 Confidence: 7.3% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:amyloid beta a4 protein; PDBTitle: solution nmr structure of transmembrane domain of amyloid precursor2 protein v44m Phyre2 PDB 2lz4 chain B Region: 58 - 81 Aligned: 24 Modelled: 24 Confidence: 7.3% Identity: 17% PDB header:membrane protein Chain: B: PDB Molecule:amyloid beta a4 protein; PDBTitle: solution nmr structure of transmembrane domain of amyloid precursor2 protein v44m Phyre2 1 c6hwhX_ 2 c2l35B_ 3 c4wo1D_ 4 c4wo1B_ 5 c4wo1C_ 6 c4wo1A_ 7 c4wolA_ 8 c2l34A_ 9 c2l34B_ 10 c4wolC_ 11 c4wolB_ 12 c2rg8A_ 13 c2lopA_ 14 c2kztA_ 15 c6hltD_ 16 c2losA_ 17 c2l35A_ 18 c2mgyA_ 19 c2lz4A_ 20 c2lz4B_ 21 22 23 24 25 26