1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	I	P	V	M	S	A	R	F	T	G	F	P	L	L	P	V	A	L	R	H	G	I	T	S	G	R	G	C	G	F	I	L	D	V	G	A	Q	R	P	F	G	N	D	V	L	L	S	V	A	T	R	K	I	R	S	R	L	P	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?														?																														?					?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	R	V	G	N	H	G	A	L	L	P	F	R	A	E	P	R	R	I	Q	M	K	R	P	P	E	V	L	R	G	A	V	T	A	S	R	E	R	L	W	A	I	G	S	Q	S	E	R	T	L	M	L	G	T	I	L	L	A	S	V
Secondary structure
SS confidence
Disorder		?	?	?															?	?	?	?	?	?	?					?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	S	A	A	T	A	Y	A	L	S	Q	W	Y	A	V	D	V	F	S	T	L	L	V	V	P	G	D	C	W	L	D	W	G	M	N	I	G	R	H	C	F	S	D	Y	A	M	V	A	A	A	G	I	Q	P	N	P	A	D	Y	L
Secondary structure
SS confidence
Disorder																																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	S	L	P	A	D	Y	Q	P	T	A	V	A	A	W	A	P	A	R	I	P	Y	A	I	F	G	L	P	S	H	W	L	G	A	P	R	L	G	L	I	C	Y	L	V	A	L	T	M	A	V	I	S	P	A	I	W	A	A	R	G
Secondary structure
SS confidence
Disorder															?																																								?	?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	R	G	L	E	R	V	V	I	F	V	T	L	G	A	A	A	I	P	A	W	G	V	I	D	R	G	N	S	T	G	F	V	V	P	I	A	L	A	Y	F	V	A	L	S	R	Q	R	W	G	L	A	T	I	T	V	I	L	A	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	V	K	P	Q	F	V	V	L	G	V	V	L	L	A	A	R	Q	W	R	W	A	G	I	G	I	T	G	V	V	V	S	N	I	A	A	F	L	L	W	P	R	G	F	P	G	T	I	A	Q	S	I	H	G	I	I	K	F	N	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	F	G	G	L	R	D	P	R	N	V	S	F	G	K	A	L	L	L	I	P	D	S	I	K	N	Y	Q	S	G	K	I	P	E	G	F	L	T	G	P	R	T	Q	I	G	F	A	V	L	V	I	V	V	V	A	V	L	A	L	G
Secondary structure
SS confidence
Disorder																													?	?			?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		R	R	I	P	P	V	M	V	G	I	V	L	L	A	T	A	T	F	S	P	A	D	V	A	F	Y	Y	L	V	F	V	L	P	I	A	A	L	V	A	R	D	P	N	G	P	P	G	A	G	I	F	D	Q	L	A	A	H	G	D	R
Secondary structure
SS confidence
Disorder															?		?	?																					?	?	?		?			?	?	?									?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		R	R	A	V	G	V	C	V	S	L	A	V	A	L	S	I	V	N	V	A	V	P	G	Q	P	F	Y	V	P	L	Y	G	Q	L	G	A	K	G	V	V	G	T	T	P	L	V	F	T	T	V	T	W	A	P	F	L	W	L	V	T
Secondary structure
SS confidence
Disorder																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.
Sequence		C	V	V	I	I	V	S	Y	A	R	K	P	A	R	P	H	D	S	H	N	G	P	T	R	E	S	D	Q	D	T	A	A	S	T	T	S	C	L	P	N	P	V	E	E	S	S	P	R	G	P	G	P	I	C	Q	N	Y	T	P
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?			?	?	?	?	?	?	?	?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 52%) Beta strand ( 8%) TM helix ( 35%) (View membrane topology prediction)

Rank Aligned region

PDB 5t42 chain A Region: 317 - 337 Aligned: 21 Modelled: 21 Confidence: 86.3% Identity: 67% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein; PDBTitle: structure of the ebola virus envelope protein mper/tm domain and its2 interaction with the fusion loop explains their fusion activity Phyre2 PDB 1s1h chain N Region: 151 - 165 Aligned: 15 Modelled: 15 Confidence: 46.2% Identity: 40% PDB header:ribosome Chain: N: PDB Molecule:40s ribosomal protein s29-b; PDBTitle: structure of the ribosomal 80s-eef2-sordarin complex from yeast2 obtained by docking atomic models for rna and protein components into3 a 11.7 a cryo-em map. this file, 1s1h, contains 40s subunit. the 60s4 ribosomal subunit is in file 1s1i. Phyre2 PDB 5a63 chain D Region: 534 - 559 Aligned: 26 Modelled: 26 Confidence: 28.6% Identity: 35% PDB header:hydrolase Chain: D: PDB Molecule:gamma-secretase subunit pen-2; PDBTitle: cryo-em structure of the human gamma-secretase complex at 3.4 angstrom2 resolution. Phyre2 PDB 4e8u chain A Region: 342 - 367 Aligned: 26 Modelled: 26 Confidence: 26.7% Identity: 42% PDB header:rna binding protein Chain: A: PDB Molecule:putative uncharacterized protein t8p19.180; PDBTitle: crystal structure of arabidopsis idn2 xs domain along with a small2 segment of adjacent coiled-coil region Phyre2 PDB 2vec chain A Region: 361 - 385 Aligned: 25 Modelled: 25 Confidence: 24.6% Identity: 24% PDB header:cytosolic protein Chain: A: PDB Molecule:pirin-like protein yhak; PDBTitle: the crystal structure of the protein yhak from escherichia2 coli Phyre2 PDB 6m8s chain M Region: 460 - 478 Aligned: 19 Modelled: 19 Confidence: 24.0% Identity: 47% PDB header:signaling protein Chain: M: PDB Molecule:btb/poz domain-containing protein kctd12; PDBTitle: crystal structure of the kctd12 h1 domain in complex with gbeta1gamma22 subunits Phyre2 PDB 1laj chain A Region: 366 - 392 Aligned: 26 Modelled: 27 Confidence: 23.3% Identity: 38% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Positive stranded ssRNA viruses Family: Bromoviridae-like VP Phyre2 PDB 1laj chain A Region: 366 - 392 Aligned: 26 Modelled: 27 Confidence: 23.3% Identity: 38% PDB header:virus/rna Chain: A: PDB Molecule:capsid protein; PDBTitle: the structure of tomato aspermy virus by x-ray2 crystallography Phyre2 PDB 3cjs chain A Region: 227 - 245 Aligned: 18 Modelled: 19 Confidence: 23.2% Identity: 39% PDB header:transferase/ribosomal protein Chain: A: PDB Molecule:ribosomal protein l11 methyltransferase; PDBTitle: minimal recognition complex between prma and ribosomal protein l11 Phyre2 PDB 1lgh chain A Region: 525 - 549 Aligned: 25 Modelled: 25 Confidence: 23.1% Identity: 44% Fold: Light-harvesting complex subunits Superfamily: Light-harvesting complex subunits Family: Light-harvesting complex subunits Phyre2 PDB 3zey chain 8 Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 21.6% Identity: 36% PDB header:ribosome Chain: 8: PDB Molecule:ribosomal protein s29, putative; PDBTitle: high-resolution cryo-electron microscopy structure of the trypanosoma2 brucei ribosome Phyre2 PDB 5xyi chain D Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 21.4% Identity: 43% PDB header:ribosome Chain: D: PDB Molecule:ribosomal protein s3, putative; PDBTitle: small subunit of trichomonas vaginalis ribosome Phyre2 PDB 3j20 chain P Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 20.4% Identity: 43% PDB header:ribosome Chain: P: PDB Molecule:30s ribosomal protein s14p type z; PDBTitle: promiscuous behavior of proteins in archaeal ribosomes revealed by2 cryo-em: implications for evolution of eukaryotic ribosomes (30s3 ribosomal subunit) Phyre2 PDB 2xzn chain N Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 20.0% Identity: 36% PDB header:ribosome Chain: N: PDB Molecule:rps29e; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 2 Phyre2 PDB 2zkq chain N Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 19.4% Identity: 50% PDB header:ribosomal protein/rna Chain: N: PDB Molecule: PDBTitle: structure of a mammalian ribosomal 40s subunit within an 80s complex2 obtained by docking homology models of the rna and proteins into an3 8.7 a cryo-em map Phyre2 PDB 6az1 chain S Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 19.1% Identity: 36% PDB header:ribosome/antibiotic Chain: S: PDB Molecule:ribosomal protein s14; PDBTitle: cryo-em structure of the small subunit of leishmania ribosome bound to2 paromomycin Phyre2 PDB 3jyv chain N Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 19.0% Identity: 43% PDB header:ribosome Chain: N: PDB Molecule:40s ribosomal protein s29(a); PDBTitle: structure of the 40s rrna and proteins and p/e trna for eukaryotic2 ribosome based on cryo-em map of thermomyces lanuginosus ribosome at3 8.9a resolution Phyre2 PDB 5xxu chain D Region: 152 - 165 Aligned: 14 Modelled: 14 Confidence: 17.9% Identity: 36% PDB header:ribosome Chain: D: PDB Molecule:ribosomal protein us3; PDBTitle: small subunit of toxoplasma gondii ribosome Phyre2 PDB 5x8r chain X Region: 358 - 381 Aligned: 23 Modelled: 24 Confidence: 17.9% Identity: 43% PDB header:ribosome Chain: X: PDB Molecule: PDBTitle: structure of the 30s small subunit of chloroplast ribosome from2 spinach Phyre2 PDB 5mmj chain X Region: 358 - 381 Aligned: 23 Modelled: 24 Confidence: 16.2% Identity: 43% PDB header:ribosome Chain: X: PDB Molecule: PDBTitle: structure of the small subunit of the chloroplast ribosome Phyre2 1 c5t42A_ 2 c1s1hN_ 3 c5a63D_ 4 c4e8uA_ 5 c2vecA_ 6 c6m8sM_ 7 d1laja_ 8 c1lajA_ 9 c3cjsA_ 10 d1lgha_ 11 c3zey8_ 12 c5xyid_ 13 c3j20P_ 14 c2xznN_ 15 c2zkqn_ 16 c6az1S_ 17 c3jyvN_ 18 c5xxud_ 19 c5x8rx_ 20 c5mmjx_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74