1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Y	E	R	R	H	E	R	G	M	C	D	R	A	V	E	M	T	D	V	G	A	T	A	A	P	T	G	P	I	A	R	G	S	V	A	R	V	G	A	A	T	A	L	A	V	A	C	V	Y	T	V	I	Y	L	A	A	R	D	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	P	A	C	F	S	I	F	A	V	F	W	G	A	L	G	I	A	T	G	A	T	H	G	L	L	Q	E	T	T	R	E	V	R	W	V	R	S	T	Q	I	V	A	G	H	R	T	H	P	L	R	V	A	G	M	I	G	T	V	A
Secondary structure
SS confidence
Disorder																							?	?														?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	V	V	I	A	G	S	S	P	L	W	S	R	Q	L	F	V	E	G	R	W	L	S	V	G	L	L	S	V	G	V	A	G	F	C	A	Q	A	T	L	L	G	A	L	A	G	V	D	R	W	T	Q	Y	G	S	L	M	V	T	D
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	V	I	R	L	A	V	A	A	A	A	V	V	I	G	W	G	L	A	G	Y	L	W	A	A	T	A	G	A	V	A	W	L	L	M	L	M	A	S	P	T	A	R	S	A	A	S	L	L	T	P	G	G	I	A	T	F	V	R	G
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	A	H	S	I	T	A	A	G	A	S	A	I	L	V	M	G	F	P	V	L	L	K	V	T	S	D	Q	L	G	A	K	G	G	A	V	I	L	A	V	T	L	T	R	A	P	L	L	V	P	L	S	A	M	Q	G	N	L	I	A
Secondary structure
SS confidence
Disorder																	?		?		?			?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		H	F	V	D	R	R	T	Q	R	L	R	A	L	I	A	P	A	L	V	V	G	G	I	G	A	V	G	M	L	A	A	G	L	T	G	P	W	L	L	R	V	G	F	G	P	D	Y	Q	T	G	G	A	L	L	A	W	L	T	A	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	V	A	I	A	M	L	T	L	T	G	A	A	A	V	A	A	A	L	H	R	A	Y	L	L	G	W	V	S	A	T	V	A	S	T	L	L	L	L	L	P	M	P	L	E	T	R	T	V	I	A	L	L	F	G	P	T	V	G	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.
Sequence		A	I	H	V	A	A	L	A	R	R	P	D
Secondary structure
SS confidence
Disorder									?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 83%) Beta strand ( 0%) TM helix ( 58%) (View membrane topology prediction)

Rank Aligned region

PDB 6cc4 chain A Region: 6 - 432 Aligned: 427 Modelled: 427 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:soluble cytochrome b562, lipid ii flippase murj chimera; PDBTitle: structure of murj from escherichia coli Phyre2 PDB 6idr chain A Region: 21 - 430 Aligned: 409 Modelled: 410 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:mate family efflux transporter; PDBTitle: crystal structure of vibrio cholerae mate transporter vcmn in the bent2 form Phyre2 PDB 5y50 chain A Region: 29 - 431 Aligned: 402 Modelled: 403 Confidence: 100.0% Identity: 9% PDB header:membrane protein Chain: A: PDB Molecule:protein detoxification 14; PDBTitle: crystal structure of eukaryotic mate transporter atdtx14 Phyre2 PDB 5xjj chain A Region: 29 - 429 Aligned: 400 Modelled: 401 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:multi drug efflux transporter; PDBTitle: crystal structure of a mate family protein Phyre2 PDB 5t77 chain A Region: 34 - 431 Aligned: 394 Modelled: 398 Confidence: 100.0% Identity: 8% PDB header:transport protein Chain: A: PDB Molecule:putative lipid ii flippase murj; PDBTitle: crystal structure of the mop flippase murj Phyre2 PDB 4lz9 chain A Region: 15 - 432 Aligned: 418 Modelled: 418 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:bh2163 protein; PDBTitle: structure of mate multidrug transporter dinf-bh in complex with r6g Phyre2 PDB 6fv6 chain A Region: 29 - 429 Aligned: 393 Modelled: 399 Confidence: 100.0% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:aq128; PDBTitle: monomer structure of the mate family multidrug resistance transporter2 aq_128 from aquifex aeolicus in the outward-facing state Phyre2 PDB 4z3p chain A Region: 22 - 430 Aligned: 403 Modelled: 409 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:putative drug/sodium antiporter; PDBTitle: mate transporter clbm in complex with rb+ Phyre2 PDB 3vvp chain A Region: 18 - 430 Aligned: 397 Modelled: 398 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of mate in complex with br-nrf Phyre2 PDB 3mku chain B Region: 26 - 432 Aligned: 406 Modelled: 407 Confidence: 99.9% Identity: 10% PDB header:transport protein Chain: B: PDB Molecule:multi antimicrobial extrusion protein (na(+)/drug PDBTitle: structure of a cation-bound multidrug and toxin compound extrusion2 (mate) transporter Phyre2 PDB 3mku chain A Region: 29 - 431 Aligned: 402 Modelled: 402 Confidence: 99.9% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:multi antimicrobial extrusion protein (na(+)/drug PDBTitle: structure of a cation-bound multidrug and toxin compound extrusion2 (mate) transporter Phyre2 PDB 4hun chain A Region: 37 - 432 Aligned: 395 Modelled: 396 Confidence: 99.4% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:multidrug efflux protein; PDBTitle: mate transporter norm-ng in complex with r6g and monobody Phyre2 PDB 4n7w chain A Region: 20 - 230 Aligned: 204 Modelled: 211 Confidence: 63.3% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:transporter, sodium/bile acid symporter family; PDBTitle: crystal structure of the sodium bile acid symporter from yersinia2 frederiksenii Phyre2 PDB 3wdo chain A Region: 26 - 431 Aligned: 378 Modelled: 385 Confidence: 39.4% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 3eps chain B Region: 9 - 24 Aligned: 16 Modelled: 16 Confidence: 15.7% Identity: 25% PDB header:transferase, hydrolase Chain: B: PDB Molecule:isocitrate dehydrogenase kinase/phosphatase; PDBTitle: the crystal structure of isocitrate dehydrogenase kinase/phosphatase2 from e. coli Phyre2 PDB 3ukz chain C Region: 1 - 9 Aligned: 9 Modelled: 9 Confidence: 15.4% Identity: 44% PDB header:protein transport/protein binding Chain: C: PDB Molecule:nuclear cap-binding protein subunit 1; PDBTitle: mouse importin alpha: mouse cbp80 cnls complex Phyre2 PDB 3dxe chain B Region: 3 - 10 Aligned: 8 Modelled: 8 Confidence: 14.3% Identity: 50% PDB header:protein binding Chain: B: PDB Molecule:amyloid beta a4 protein; PDBTitle: crystal structure of the intracellular domain of human app (t668a2 mutant) in complex with fe65-ptb2 Phyre2 PDB 1l4a chain E Region: 3 - 18 Aligned: 16 Modelled: 16 Confidence: 12.6% Identity: 50% PDB header:endocytosis/exocytosis Chain: E: PDB Molecule:synaphin a; PDBTitle: x-ray structure of the neuronal complexin/snare complex2 from the squid loligo pealei Phyre2 PDB 3efd chain K Region: 5 - 19 Aligned: 15 Modelled: 15 Confidence: 12.0% Identity: 33% PDB header:immune system Chain: K: PDB Molecule:kcsa; PDBTitle: the crystal structure of the cytoplasmic domain of kcsa Phyre2 PDB 5mg3 chain D Region: 10 - 101 Aligned: 88 Modelled: 92 Confidence: 11.7% Identity: 10% PDB header:chaperone Chain: D: PDB Molecule:protein translocase subunit secd; PDBTitle: em fitted model of bacterial holo-translocon Phyre2 1 c6cc4A_ 2 c6idrA_ 3 c5y50A_ 4 c5xjjA_ 5 c5t77A_ 6 c4lz9A_ 7 c6fv6A_ 8 c4z3pA_ 9 c3vvpA_ 10 c3mkuB_ 11 c3mkuA_ 12 c4hunA_ 13 c4n7wA_ 14 c3wdoA_ 15 c3epsB_ 16 c3ukzC_ 17 c3dxeB_ 18 c1l4aE_ 19 c3efdK_ 20 c5mg3D_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69