1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	D	E	P	T	G	S	A	D	P	L	T	S	T	E	E	A	G	G	A	G	E	P	N	A	P	A	P	P	R	R	L	R	M	L	L	S	V	A	V	V	V	L	T	L	D	I	V	T	K	V	V	A	V	Q	L	L	P	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	Q	P	V	S	I	I	G	D	T	V	T	W	T	L	V	R	N	S	G	A	A	F	S	M	A	T	G	Y	T	W	V	L	T	L	I	A	T	G	V	V	V	G	I	F	W	M	G	R	R	L	V	S	P	W	W	A	L	G	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	M	I	L	G	G	A	M	G	N	L	V	D	R	F	F	R	A	P	G	P	L	R	G	H	V	V	D	F	L	S	V	G	W	W	P	V	F	N	V	A	D	P	S	V	V	G	G	A	I	L	L	V	I	L	S	I	F	G	F
Secondary structure
SS confidence
Disorder																						?																																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.
Sequence		D	F	D	T	V	G	R	R	H	A	D	G	D	T	V	G	R	R	K	A	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 53%) Beta strand ( 10%) TM helix ( 38%) (View membrane topology prediction)

Rank Aligned region

PDB 5dir chain D Region: 36 - 179 Aligned: 138 Modelled: 143 Confidence: 100.0% Identity: 38% PDB header:hydrolase Chain: D: PDB Molecule:lipoprotein signal peptidase; PDBTitle: membrane protein at 2.8 angstroms Phyre2 PDB 5dir chain B Region: 25 - 176 Aligned: 145 Modelled: 151 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: B: PDB Molecule:lipoprotein signal peptidase; PDBTitle: membrane protein at 2.8 angstroms Phyre2 PDB 6btm chain C Region: 91 - 202 Aligned: 106 Modelled: 112 Confidence: 83.7% Identity: 11% PDB header:membrane protein Chain: C: PDB Molecule:alternative complex iii subunit c; PDBTitle: structure of alternative complex iii from flavobacterium johnsoniae2 (wild type) Phyre2 PDB 2knc chain A Region: 163 - 194 Aligned: 32 Modelled: 32 Confidence: 43.1% Identity: 25% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2oar chain A domain 1 Region: 111 - 150 Aligned: 30 Modelled: 40 Confidence: 36.5% Identity: 23% Fold: Gated mechanosensitive channel Superfamily: Gated mechanosensitive channel Family: Gated mechanosensitive channel Phyre2 PDB 3qnq chain D Region: 163 - 197 Aligned: 35 Modelled: 35 Confidence: 26.3% Identity: 20% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 2mfr chain A Region: 145 - 179 Aligned: 31 Modelled: 35 Confidence: 18.7% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:insulin receptor; PDBTitle: solution structure of the transmembrane domain of the insulin receptor2 in micelles Phyre2 PDB 6f0k chain C Region: 91 - 178 Aligned: 80 Modelled: 88 Confidence: 16.8% Identity: 13% PDB header:membrane protein Chain: C: PDB Molecule:polysulphide reductase nrfd; PDBTitle: alternative complex iii Phyre2 PDB 5ire chain A Region: 80 - 124 Aligned: 45 Modelled: 45 Confidence: 16.7% Identity: 24% PDB header:virus Chain: A: PDB Molecule:e protein; PDBTitle: the cryo-em structure of zika virus Phyre2 PDB 6fki chain P Region: 84 - 112 Aligned: 29 Modelled: 29 Confidence: 15.8% Identity: 7% PDB header:membrane protein Chain: P: PDB Molecule:atp synthase subunit c, chloroplastic; PDBTitle: chloroplast f1fo conformation 3 Phyre2 PDB 5v8k chain B Region: 156 - 164 Aligned: 9 Modelled: 9 Confidence: 14.0% Identity: 56% PDB header:photosynthesis Chain: B: PDB Molecule:proteinsubunit pshx; PDBTitle: homodimeric reaction center of h. modesticaldum Phyre2 PDB 6iuh chain C Region: 2 - 10 Aligned: 9 Modelled: 9 Confidence: 12.0% Identity: 33% PDB header:protein binding Chain: C: PDB Molecule:liprin-alpha-2; PDBTitle: crystal structure of git1 pbd domain in complex with liprin-alpha2 Phyre2 PDB 3rb8 chain A Region: 125 - 152 Aligned: 21 Modelled: 28 Confidence: 11.9% Identity: 19% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of the phage tubulin phuz(semet)-gdp Phyre2 PDB 6btm chain F Region: 91 - 197 Aligned: 95 Modelled: 107 Confidence: 10.6% Identity: 9% PDB header:membrane protein Chain: F: PDB Molecule:alternative complex iii subunit f; PDBTitle: structure of alternative complex iii from flavobacterium johnsoniae2 (wild type) Phyre2 PDB 2d5b chain A domain 1 Region: 124 - 136 Aligned: 13 Modelled: 13 Confidence: 10.2% Identity: 46% Fold: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Superfamily: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Family: Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Phyre2 PDB 2d46 chain A Region: 1 - 19 Aligned: 19 Modelled: 19 Confidence: 10.1% Identity: 37% PDB header:metal transport Chain: A: PDB Molecule:calcium channel, voltage-dependent, beta 4 PDBTitle: solution structure of the human beta4a-a domain Phyre2 PDB 2oar chain A Region: 111 - 136 Aligned: 26 Modelled: 26 Confidence: 9.6% Identity: 23% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: mechanosensitive channel of large conductance (mscl) Phyre2 PDB 6f0k chain F Region: 91 - 178 Aligned: 77 Modelled: 88 Confidence: 9.1% Identity: 16% PDB header:membrane protein Chain: F: PDB Molecule:actf; PDBTitle: alternative complex iii Phyre2 PDB 6oit chain G Region: 127 - 148 Aligned: 19 Modelled: 22 Confidence: 8.4% Identity: 26% PDB header:plant protein Chain: G: PDB Molecule:protein chromatin remodeling 35; PDBTitle: cryoem structure of arabidopsis ddr' complex (drd1 peptide-dms3-rdm1) Phyre2 PDB 3hzq chain A Region: 111 - 136 Aligned: 26 Modelled: 26 Confidence: 7.8% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: structure of a tetrameric mscl in an expanded intermediate state Phyre2 1 c5dirD_ 2 c5dirB_ 3 c6btmC_ 4 c2kncA_ 5 d2oara1 6 c3qnqD_ 7 c2mfrA_ 8 c6f0kC_ 9 c5ireA_ 10 c6fkip_ 11 c5v8kB_ 12 c6iuhC_ 13 c3rb8A_ 14 c6btmF_ 15 d2d5ba1 16 c2d46A_ 17 c2oarA_ 18 c6f0kF_ 19 c6oitG_ 20 c3hzqA_ 21 22 23 24 25 26 27 28 29