1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	Y	R	Q	P	V	E	R	Y	W	W	A	R	R	R	S	Y	L	R	F	M	L	R	E	I	S	C	I	F	V	A	W	F	V	L	Y	L	M	L	V	L	R	A	V	G	A	G	G	N	S	Y	Q	R	F	L	D	F	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	N	P	V	V	V	V	L	N	V	V	A	L	S	F	L	L	L	H	A	V	T	W	F	G	S	A	P	R	A	M	V	I	Q	V	R	G	R	R	V	P	A	R	A	V	L	A	G	H	Y	A	A	W	L	V	V	S	V	I	V
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		A	W	M	V	L	S
Secondary structure
SS confidence
Disorder					?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 19%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 47%) (View membrane topology prediction)

Rank Aligned region

PDB 1kf6 chain C Region: 2 - 125 Aligned: 124 Modelled: 124 Confidence: 100.0% Identity: 31% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 1nek chain D Region: 20 - 80 Aligned: 59 Modelled: 61 Confidence: 96.8% Identity: 24% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 1nek chain C Region: 24 - 81 Aligned: 58 Modelled: 58 Confidence: 92.7% Identity: 17% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 3vrb chain G Region: 24 - 119 Aligned: 91 Modelled: 96 Confidence: 88.4% Identity: 10% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: G: PDB Molecule:cytochrome b-large subunit; PDBTitle: mitochondrial rhodoquinol-fumarate reductase from the parasitic2 nematode ascaris suum with the specific inhibitor flutolanil and3 substrate fumarate Phyre2 PDB 5xmj chain G Region: 15 - 81 Aligned: 66 Modelled: 67 Confidence: 75.3% Identity: 12% PDB header:electron transport Chain: G: PDB Molecule:fumarate reductase respiratory complex; PDBTitle: crystal structure of quinol:fumarate reductase from desulfovibrio2 gigas Phyre2 PDB 2bs2 chain C domain 1 Region: 14 - 78 Aligned: 65 Modelled: 65 Confidence: 68.1% Identity: 14% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Fumarate reductase respiratory complex cytochrome b subunit, FrdC Phyre2 PDB 1kf6 chain D Region: 28 - 125 Aligned: 89 Modelled: 98 Confidence: 53.0% Identity: 20% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 1yq3 chain C Region: 24 - 125 Aligned: 97 Modelled: 102 Confidence: 52.7% Identity: 9% PDB header:oxidoreductase Chain: C: PDB Molecule:succinate dehydrogenase cytochrome b, large subunit; PDBTitle: avian respiratory complex ii with oxaloacetate and ubiquinone Phyre2 PDB 2n7i chain A Region: 110 - 125 Aligned: 16 Modelled: 16 Confidence: 32.8% Identity: 13% PDB header:hormone receptor Chain: A: PDB Molecule:prolactin receptor; PDBTitle: nmr structure of the prolactin receptor transmembrane domain Phyre2 PDB 2mb9 chain A Region: 43 - 62 Aligned: 20 Modelled: 20 Confidence: 26.2% Identity: 5% PDB header:signaling protein Chain: A: PDB Molecule:b-cell lymphoma/leukemia 10; PDBTitle: human bcl10 card Phyre2 PDB 1lg7 chain A Region: 15 - 25 Aligned: 11 Modelled: 11 Confidence: 24.8% Identity: 18% Fold: VSV matrix protein Superfamily: VSV matrix protein Family: VSV matrix protein Phyre2 PDB 2b1w chain A Region: 47 - 66 Aligned: 20 Modelled: 20 Confidence: 24.0% Identity: 20% PDB header:apoptosis Chain: A: PDB Molecule:caspase recruitment domain protein 4; PDBTitle: solution structure of the nod1 caspase activating and recruitment2 domain Phyre2 PDB 1p58 chain E Region: 7 - 42 Aligned: 36 Modelled: 36 Confidence: 22.6% Identity: 17% PDB header:virus Chain: E: PDB Molecule:envelope protein m; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 6e28 chain D Region: 47 - 61 Aligned: 15 Modelled: 15 Confidence: 21.4% Identity: 27% PDB header:signaling protein Chain: D: PDB Molecule:caspase recruitment domain-containing protein 9; PDBTitle: the card9 card domain-swapped dimer Phyre2 PDB 2w2r chain A Region: 15 - 25 Aligned: 11 Modelled: 11 Confidence: 21.4% Identity: 27% PDB header:viral protein Chain: A: PDB Molecule:matrix protein; PDBTitle: structure of the vesicular stomatitis virus matrix protein Phyre2 PDB 6j52 chain A Region: 47 - 62 Aligned: 16 Modelled: 16 Confidence: 19.2% Identity: 19% PDB header:apoptosis Chain: A: PDB Molecule:caspase recruitment domain-only protein; PDBTitle: crystal structure of card-only protein in frog virus 3 Phyre2 PDB 2m5l chain A Region: 88 - 102 Aligned: 15 Modelled: 15 Confidence: 17.6% Identity: 47% PDB header:viral protein Chain: A: PDB Molecule:ns5a protein; PDBTitle: ns5a308 Phyre2 PDB 6ajn chain F Region: 49 - 63 Aligned: 15 Modelled: 15 Confidence: 17.5% Identity: 33% PDB header:toxin Chain: F: PDB Molecule:duf1778 domain-containing protein; PDBTitle: crystal structure of atatr bound with accoa Phyre2 PDB 3ygs chain P Region: 47 - 62 Aligned: 16 Modelled: 16 Confidence: 16.9% Identity: 13% Fold: DEATH domain Superfamily: DEATH domain Family: Caspase recruitment domain, CARD Phyre2 PDB 6n2m chain A Region: 47 - 61 Aligned: 15 Modelled: 15 Confidence: 16.5% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:caspase recruitment domain-containing protein 9; PDBTitle: nmr solution structure of the homodimeric, autoinhibited state of the2 card9 card and first coiled-coil Phyre2 1 d1kf6c_ 2 d1nekd_ 3 d1nekc_ 4 c3vrbG_ 5 c5xmjG_ 6 d2bs2c1 7 d1kf6d_ 8 c1yq3C_ 9 c2n7iA_ 10 c2mb9A_ 11 d1lg7a_ 12 c2b1wA_ 13 c1p58E_ 14 c6e28D_ 15 c2w2rA_ 16 c6j52A_ 17 c2m5lA_ 18 c6ajnF_ 19 d3ygsp_ 20 c6n2mA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52