1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	P	S	T	S	D	A	R	S	R	R	R	S	A	E	P	F	L	W	L	L	F	S	A	G	G	M	V	T	A	L	V	A	P	V	L	L	L	L	F	G	L	A	F	P	L	G	W	L	D	A	P	D	H	G	H	L	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	V	R	N	P	I	T	K	L	V	V	L	V	L	V	V	L	A	L	F	H	A	A	H	R	F	R	F	V	L	D	H	G	L	Q	L	G	R	F	D	R	V	I	A	L	W	C	Y	G	M	A	V	L	G	S	A	T	A	G	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.
Sequence		M	L	L	T	M
Secondary structure
SS confidence
Disorder					?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 12%) Alpha helix ( 89%) Beta strand ( 0%) TM helix ( 54%) (View membrane topology prediction)

Rank Aligned region

PDB 1kf6 chain D Region: 9 - 125 Aligned: 113 Modelled: 117 Confidence: 100.0% Identity: 31% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 1nek chain C Region: 16 - 122 Aligned: 107 Modelled: 107 Confidence: 93.2% Identity: 12% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 1nek chain D Region: 29 - 125 Aligned: 91 Modelled: 97 Confidence: 72.0% Identity: 14% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 4ymk chain A Region: 1 - 108 Aligned: 103 Modelled: 108 Confidence: 54.7% Identity: 10% PDB header:oxidoreductase Chain: A: PDB Molecule:acyl-coa desaturase 1; PDBTitle: crystal structure of stearoyl-coenzyme a desaturase 1 Phyre2 PDB 1kf6 chain C Region: 5 - 123 Aligned: 118 Modelled: 119 Confidence: 50.4% Identity: 14% Fold: Heme-binding four-helical bundle Superfamily: Fumarate reductase respiratory complex transmembrane subunits Family: Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD) Phyre2 PDB 2lj2 chain A Region: 26 - 63 Aligned: 38 Modelled: 38 Confidence: 28.1% Identity: 37% PDB header:membrane protein Chain: A: PDB Molecule:merf; PDBTitle: integral membrane core domain of the mercury transporter merf in lipid2 bilayer membranes Phyre2 PDB 3vrb chain G Region: 16 - 116 Aligned: 101 Modelled: 101 Confidence: 25.6% Identity: 21% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: G: PDB Molecule:cytochrome b-large subunit; PDBTitle: mitochondrial rhodoquinol-fumarate reductase from the parasitic2 nematode ascaris suum with the specific inhibitor flutolanil and3 substrate fumarate Phyre2 PDB 2m67 chain A Region: 26 - 63 Aligned: 38 Modelled: 38 Confidence: 22.9% Identity: 37% PDB header:transport protein Chain: A: PDB Molecule:merf; PDBTitle: full-length mercury transporter protein merf in lipid bilayer2 membranes Phyre2 PDB 1cii chain A Region: 25 - 71 Aligned: 42 Modelled: 47 Confidence: 17.3% Identity: 38% PDB header:transmembrane protein Chain: A: PDB Molecule:colicin ia; PDBTitle: colicin ia Phyre2 PDB 6bm8 chain A Region: 58 - 76 Aligned: 19 Modelled: 19 Confidence: 16.1% Identity: 32% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein b; PDBTitle: crystal structure of glycoprotein b from herpes simplex virus type i Phyre2 PDB 2m86 chain A Region: 19 - 27 Aligned: 9 Modelled: 9 Confidence: 15.6% Identity: 67% PDB header:protein binding/signaling protein Chain: A: PDB Molecule:mco-pmi; PDBTitle: solution structure of hdm2 with engineered cyclotide Phyre2 PDB 5h2s chain A Region: 21 - 33 Aligned: 13 Modelled: 13 Confidence: 14.5% Identity: 46% PDB header:antimicrobial protein Chain: A: PDB Molecule:piscidin-4; PDBTitle: solution structure of tilapia piscidin 4 (tp4) from oreochromis2 niloticus Phyre2 PDB 1yq3 chain C Region: 16 - 122 Aligned: 107 Modelled: 107 Confidence: 13.4% Identity: 17% PDB header:oxidoreductase Chain: C: PDB Molecule:succinate dehydrogenase cytochrome b, large subunit; PDBTitle: avian respiratory complex ii with oxaloacetate and ubiquinone Phyre2 PDB 2jo1 chain A Region: 29 - 45 Aligned: 17 Modelled: 17 Confidence: 10.1% Identity: 24% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 5xmj chain G Region: 40 - 123 Aligned: 84 Modelled: 84 Confidence: 9.8% Identity: 15% PDB header:electron transport Chain: G: PDB Molecule:fumarate reductase respiratory complex; PDBTitle: crystal structure of quinol:fumarate reductase from desulfovibrio2 gigas Phyre2 PDB 2y69 chain Z Region: 32 - 57 Aligned: 26 Modelled: 26 Confidence: 9.7% Identity: 12% PDB header:electron transport Chain: Z: PDB Molecule:cytochrome c oxidase polypeptide 8h; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular oxygen Phyre2 PDB 1kwi chain A Region: 7 - 22 Aligned: 16 Modelled: 16 Confidence: 9.5% Identity: 25% Fold: Cystatin-like Superfamily: Cystatin/monellin Family: Cathelicidin motif Phyre2 PDB 2c52 chain B domain 1 Region: 3 - 13 Aligned: 11 Modelled: 11 Confidence: 8.5% Identity: 27% Fold: Nuclear receptor coactivator interlocking domain Superfamily: Nuclear receptor coactivator interlocking domain Family: Nuclear receptor coactivator interlocking domain Phyre2 PDB 2jp3 chain A Region: 29 - 45 Aligned: 17 Modelled: 17 Confidence: 8.3% Identity: 29% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 5wsn chain C Region: 3 - 15 Aligned: 13 Modelled: 13 Confidence: 8.2% Identity: 31% PDB header:virus Chain: C: PDB Molecule:e protein; PDBTitle: structure of japanese encephalitis virus Phyre2 1 d1kf6d_ 2 d1nekc_ 3 d1nekd_ 4 c4ymkA_ 5 d1kf6c_ 6 c2lj2A_ 7 c3vrbG_ 8 c2m67A_ 9 c1ciiA_ 10 c6bm8A_ 11 c2m86A_ 12 c5h2sA_ 13 c1yq3C_ 14 c2jo1A_ 15 c5xmjG_ 16 c2y69Z_ 17 d1kwia_ 18 d2c52b1 19 c2jp3A_ 20 c5wsnC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43