1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	Y	R	W	C	M	S	R	T	N	I	D	I	D	D	E	L	A	A	E	V	M	R	R	F	G	L	T	T	K	R	A	A	V	D	L	A	L	R	R	L	V	G	S	P	L	S	R	E	F	L	L	G	L	E	G	V	G	W	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																		?		?	?	?															?		?								?			?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.
Sequence		G	D	L	D	D	L	R	S	D	R	P	D
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 72%) Beta strand ( 0%)

Rank Aligned region

PDB 6a7v chain U Region: 7 - 68 Aligned: 62 Modelled: 62 Confidence: 99.9% Identity: 100% PDB header:toxin/antitoxin Chain: U: PDB Molecule:antitoxin vapb11; PDBTitle: crystal structure of mycobacterium tuberculosis vapbc11 toxin-2 antitoxin complex Phyre2 PDB 2k5j chain B Region: 6 - 45 Aligned: 40 Modelled: 40 Confidence: 81.5% Identity: 13% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein yiif; PDBTitle: solution structure of protein yiif from shigella flexneri2 serotype 5b (strain 8401) . northeast structural genomics3 consortium target sft1 Phyre2 PDB 1q5v chain B Region: 6 - 42 Aligned: 37 Modelled: 37 Confidence: 81.1% Identity: 30% PDB header:transcription Chain: B: PDB Molecule:nickel responsive regulator; PDBTitle: apo-nikr Phyre2 PDB 2bj7 chain A domain 1 Region: 6 - 46 Aligned: 41 Modelled: 41 Confidence: 80.3% Identity: 17% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2ca9 chain B Region: 6 - 49 Aligned: 44 Modelled: 44 Confidence: 77.8% Identity: 18% PDB header:transcription Chain: B: PDB Molecule:putative nickel-responsive regulator; PDBTitle: apo-nikr from helicobacter pylori in closed trans-2 conformation Phyre2 PDB 2bj3 chain D Region: 6 - 46 Aligned: 41 Modelled: 41 Confidence: 74.0% Identity: 17% PDB header:transcription Chain: D: PDB Molecule:nickel responsive regulator; PDBTitle: nikr-apo Phyre2 PDB 5ceg chain C Region: 6 - 53 Aligned: 48 Modelled: 48 Confidence: 64.2% Identity: 13% PDB header:toxin Chain: C: PDB Molecule:addiction module antidote protein, copg/arc/metj family; PDBTitle: x-ray structure of toxin/anti-toxin complex from mesorhizobium2 opportunistum Phyre2 PDB 5vgt chain A Region: 27 - 41 Aligned: 15 Modelled: 15 Confidence: 55.4% Identity: 40% PDB header:viral protein Chain: A: PDB Molecule:gene 7 protein; PDBTitle: x-ray structure of bacteriophage sf6 tail adaptor protein gp7 Phyre2 PDB 3kxe chain D Region: 9 - 54 Aligned: 46 Modelled: 46 Confidence: 54.8% Identity: 13% PDB header:protein binding Chain: D: PDB Molecule:antitoxin protein pard-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex Phyre2 PDB 2hza chain A domain 1 Region: 8 - 49 Aligned: 42 Modelled: 42 Confidence: 43.8% Identity: 26% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2hza chain B domain 1 Region: 8 - 42 Aligned: 35 Modelled: 35 Confidence: 39.9% Identity: 29% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2l9i chain A Region: 27 - 37 Aligned: 11 Modelled: 11 Confidence: 21.2% Identity: 36% PDB header:peptide binding protein Chain: A: PDB Molecule:thymosin alpha-1; PDBTitle: nmr structure of thymosin alpha-1 Phyre2 PDB 1dqu chain A Region: 15 - 69 Aligned: 55 Modelled: 55 Confidence: 19.3% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Phosphoenolpyruvate/pyruvate domain Family: Phosphoenolpyruvate mutase/Isocitrate lyase-like Phyre2 PDB 4zqu chain B Region: 15 - 33 Aligned: 19 Modelled: 19 Confidence: 19.3% Identity: 42% PDB header:toxin Chain: B: PDB Molecule:cdii toxin; PDBTitle: cdia-ct/cdii toxin and immunity complex from yersinia2 pseudotuberculosis Phyre2 PDB 1y66 chain D Region: 32 - 46 Aligned: 15 Modelled: 15 Confidence: 18.6% Identity: 20% PDB header:de novo protein Chain: D: PDB Molecule:engrailed homeodomain; PDBTitle: dioxane contributes to the altered conformation and2 oligomerization state of a designed engrailed homeodomain3 variant Phyre2 PDB 2k29 chain A Region: 6 - 25 Aligned: 20 Modelled: 20 Confidence: 18.3% Identity: 40% PDB header:transcription Chain: A: PDB Molecule:antitoxin relb; PDBTitle: structure of the dbd domain of e. coli antitoxin relb Phyre2 PDB 2kel chain B Region: 32 - 45 Aligned: 14 Modelled: 14 Confidence: 16.5% Identity: 14% PDB header:transcription repressor Chain: B: PDB Molecule:uncharacterized protein 56b; PDBTitle: structure of the transcription regulator svtr from the2 hyperthermophilic archaeal virus sirv1 Phyre2 PDB 1r0m chain A domain 2 Region: 15 - 56 Aligned: 42 Modelled: 42 Confidence: 15.5% Identity: 21% Fold: Enolase N-terminal domain-like Superfamily: Enolase N-terminal domain-like Family: Enolase N-terminal domain-like Phyre2 PDB 1kn0 chain A Region: 28 - 43 Aligned: 16 Modelled: 16 Confidence: 14.9% Identity: 25% Fold: dsRBD-like Superfamily: dsRNA-binding domain-like Family: The homologous-pairing domain of Rad52 recombinase Phyre2 PDB 1irq chain A Region: 31 - 45 Aligned: 15 Modelled: 15 Confidence: 14.6% Identity: 20% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: Omega transcriptional repressor Phyre2 1 c6a7vU_ 2 c2k5jB_ 3 c1q5vB_ 4 d2bj7a1 5 c2ca9B_ 6 c2bj3D_ 7 c5cegC_ 8 c5vgtA_ 9 c3kxeD_ 10 d2hzaa1 11 d2hzab1 12 c2l9iA_ 13 d1dqua_ 14 c4zquB_ 15 c1y66D_ 16 c2k29A_ 17 c2kelB_ 18 d1r0ma2 19 d1kn0a_ 20 d1irqa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63