1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	H	S	I	E	L	V	F	D	S	D	T	E	A	A	I	R	R	I	W	A	G	L	A	A	A	G	I	P	S	Q	A	P	A	S	R	P	H	V	S	L	A	V	A	E	R	I	A	P	E	V	D	E	P	L	G	A	V	A
Secondary structure
SS confidence
Disorder		?	?	?																												?	?	?	?	?		?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	R	L	P	L	D	C	V	I	G	A	P	V	L	F	G	R	A	N	V	V	F	T	R	L	V	V	P	T	S	E	L	L	A	L	H	A	E	V	H	R	L	C	G	P	H	L	A	P	A	P	M	A	N	S	L	P	G	Q	W
Secondary structure
SS confidence
Disorder		?	?																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.
Sequence		T	A	H	V	T	L	A	R	R	V	G	G	H	Q	L	G	R	A	L	R	I	A	G	R	P	S	R	I	D	G	R	F	A	G	L	R	R	W	D	G	N	T	R	A	E	Y	L	L	G
Secondary structure
SS confidence
Disorder										?	?																	?	?	?														?	?	?			?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 34%) Beta strand ( 29%)

Rank Aligned region

PDB 2d4g chain A Region: 1 - 166 Aligned: 153 Modelled: 151 Confidence: 99.9% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein bsu11850; PDBTitle: structure of yjcg protein, a putative 2'-5' rna ligase from bacillus2 subtilis Phyre2 PDB 1jh6 chain A Region: 2 - 167 Aligned: 154 Modelled: 154 Confidence: 99.9% Identity: 16% Fold: LigT-like Superfamily: LigT-like Family: tRNA splicing product Appr>p cyclic nucleotide phosphodiesterase Phyre2 PDB 4qak chain A Region: 5 - 167 Aligned: 151 Modelled: 163 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:2'-5'-rna ligase; PDBTitle: crystal structure of phosphoesterase Phyre2 PDB 1vdx chain A Region: 1 - 167 Aligned: 161 Modelled: 167 Confidence: 99.9% Identity: 12% PDB header:ligase Chain: A: PDB Molecule:hypothetical protein ph0099; PDBTitle: crystal structure of a pyrococcus horikoshii protein with2 similarities to 2'5' rna-ligase Phyre2 PDB 5h7e chain A Region: 5 - 167 Aligned: 151 Modelled: 163 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:rna 2',3'-cyclic phosphodiesterase; PDBTitle: crystal structure of native drcpdase Phyre2 PDB 1iuh chain A Region: 1 - 167 Aligned: 162 Modelled: 162 Confidence: 99.9% Identity: 14% Fold: LigT-like Superfamily: LigT-like Family: 2'-5' RNA ligase LigT Phyre2 PDB 2vfy chain A Region: 1 - 128 Aligned: 122 Modelled: 128 Confidence: 99.8% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:akap18 delta; PDBTitle: akap18 delta central domain Phyre2 PDB 3j4r chain A Region: 3 - 128 Aligned: 120 Modelled: 126 Confidence: 99.8% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:a-kinase anchor protein 18; PDBTitle: pseudo-atomic model of the akap18-pka complex in a linear conformation2 derived from electron microscopy Phyre2 PDB 4h7w chain A Region: 5 - 128 Aligned: 118 Modelled: 124 Confidence: 99.7% Identity: 14% PDB header:unknown function Chain: A: PDB Molecule:upf0406 protein c16orf57; PDBTitle: crystal structure of human c16orf57 Phyre2 PDB 4z5v chain A Region: 19 - 128 Aligned: 99 Modelled: 110 Confidence: 97.9% Identity: 20% PDB header:viral protein Chain: A: PDB Molecule:non-structural protein 2a; PDBTitle: crystal structure of mhv ns2 pde domain Phyre2 PDB 2fsq chain A domain 1 Region: 4 - 143 Aligned: 135 Modelled: 138 Confidence: 93.7% Identity: 18% Fold: LigT-like Superfamily: LigT-like Family: Atu0111-like Phyre2 PDB 5uqj chain A Region: 5 - 142 Aligned: 133 Modelled: 138 Confidence: 87.5% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:u6 snrna phosphodiesterase; PDBTitle: structure of yeast usb1 Phyre2 PDB 1em8 chain A Region: 82 - 127 Aligned: 33 Modelled: 33 Confidence: 48.9% Identity: 15% Fold: DNA polymerase III chi subunit Superfamily: DNA polymerase III chi subunit Family: DNA polymerase III chi subunit Phyre2 PDB 3gr1 chain A Region: 1 - 61 Aligned: 61 Modelled: 61 Confidence: 35.3% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:protein prgh; PDBTitle: periplasmic domain of the t3ss inner membrane protein prgh from2 s.typhimurium (fragment 170-392) Phyre2 PDB 3ce8 chain A Region: 40 - 108 Aligned: 69 Modelled: 69 Confidence: 34.2% Identity: 13% PDB header:unknown function Chain: A: PDB Molecule:putative pii-like nitrogen regulatory protein; PDBTitle: crystal structure of a duf3240 family protein (sbal_0098) from2 shewanella baltica os155 at 2.40 a resolution Phyre2 PDB 2i3e chain A Region: 30 - 85 Aligned: 56 Modelled: 56 Confidence: 25.5% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:g-rich; PDBTitle: solution structure of catalytic domain of goldfish rich2 protein Phyre2 PDB 5af2 chain C Region: 27 - 127 Aligned: 92 Modelled: 101 Confidence: 21.2% Identity: 17% PDB header:hydrolase Chain: C: PDB Molecule:vp3; PDBTitle: crystal structure of the c-terminal 2',5'-phosphodiesterase2 domain of group a rotavirus protein vp3 Phyre2 PDB 2ilx chain A domain 1 Region: 34 - 142 Aligned: 99 Modelled: 109 Confidence: 20.5% Identity: 22% Fold: LigT-like Superfamily: LigT-like Family: 2',3'-cyclic nucleotide 3'-phosphodiesterase, catalytic domain Phyre2 PDB 2n9z chain A Region: 115 - 124 Aligned: 10 Modelled: 10 Confidence: 6.1% Identity: 20% PDB header:toxin Chain: A: PDB Molecule:tau-theraphotoxin-hs1a; PDBTitle: solution structure of k1 lobe of double-knot toxin Phyre2 1 c2d4gA_ 2 d1jh6a_ 3 c4qakA_ 4 c1vdxA_ 5 c5h7eA_ 6 d1iuha_ 7 c2vfyA_ 8 c3j4rA_ 9 c4h7wA_ 10 c4z5vA_ 11 d2fsqa1 12 c5uqjA_ 13 d1em8a_ 14 c3gr1A_ 15 c3ce8A_ 16 c2i3eA_ 17 c5af2C_ 18 d2ilxa1 19 c2n9zA_