1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	A	V	A	I	T	P	A	S	G	G	R	H	S	V	R	F	A	Y	D	S	A	I	V	S	L	I	K	S	T	I	P	A	Y	A	R	S	W	S	A	H	T	R	C	W	F	I	D	A	D	W	T	P	L	L	A	A	E	L
Secondary structure
SS confidence
Disorder		?	?	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	Y	H	G	H	T	V	T	G	P	A	D	P	A	Q	Q	Q	C	T	D	W	A	K	A	L	F	R	A	V	G	P	Q	R	T	P	A	V	Y	R	A	L	S	K	V	L	H	P	D	A	P	T	G	C	P	I	L	Q	Q	Q	L
Secondary structure
SS confidence
Disorder											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.
Sequence		N	A	A	R	T	A	L	T	N	P	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 55%) Beta strand ( 11%)

Rank Aligned region

PDB 1qnt chain A domain 2 Region: 59 - 118 Aligned: 47 Modelled: 60 Confidence: 89.1% Identity: 30% Fold: Ribonuclease H-like motif Superfamily: Methylated DNA-protein cysteine methyltransferase domain Family: Methylated DNA-protein cysteine methyltransferase domain Phyre2 PDB 2guz chain O Region: 96 - 127 Aligned: 31 Modelled: 32 Confidence: 87.6% Identity: 35% PDB header:chaperone, protein transport Chain: O: PDB Molecule:mitochondrial import inner membrane translocase subunit PDBTitle: structure of the tim14-tim16 complex of the mitochondrial protein2 import motor Phyre2 PDB 3hho chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 86.3% Identity: 36% PDB header:chaperone Chain: A: PDB Molecule:co-chaperone protein hscb homolog; PDBTitle: chaperone hscb from vibrio cholerae Phyre2 PDB 3bvo chain A Region: 44 - 130 Aligned: 79 Modelled: 87 Confidence: 81.3% Identity: 24% PDB header:chaperone Chain: A: PDB Molecule:co-chaperone protein hscb, mitochondrial precursor; PDBTitle: crystal structure of human co-chaperone protein hscb Phyre2 PDB 2och chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 80.9% Identity: 24% PDB header:chaperone Chain: A: PDB Molecule:hypothetical protein dnj-12; PDBTitle: j-domain of dnj-12 from caenorhabditis elegans Phyre2 PDB 2o37 chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 80.6% Identity: 33% PDB header:chaperone Chain: A: PDB Molecule:protein sis1; PDBTitle: j-domain of sis1 protein, hsp40 co-chaperone from saccharomyces2 cerevisiae. Phyre2 PDB 2guz chain D Region: 98 - 127 Aligned: 29 Modelled: 30 Confidence: 79.0% Identity: 24% PDB header:chaperone, protein transport Chain: D: PDB Molecule:mitochondrial import inner membrane translocase subunit PDBTitle: structure of the tim14-tim16 complex of the mitochondrial protein2 import motor Phyre2 PDB 1gh6 chain A Region: 82 - 130 Aligned: 48 Modelled: 49 Confidence: 77.3% Identity: 21% Fold: Long alpha-hairpin Superfamily: Chaperone J-domain Family: Chaperone J-domain Phyre2 PDB 1xbl chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 75.3% Identity: 27% Fold: Long alpha-hairpin Superfamily: Chaperone J-domain Family: Chaperone J-domain Phyre2 PDB 1hdj chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 71.0% Identity: 24% Fold: Long alpha-hairpin Superfamily: Chaperone J-domain Family: Chaperone J-domain Phyre2 PDB 2lgw chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 70.4% Identity: 21% PDB header:chaperone Chain: A: PDB Molecule:dnaj homolog subfamily b member 2; PDBTitle: solution structure of the j domain of hsj1a Phyre2 PDB 1fpo chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 70.2% Identity: 27% PDB header:chaperone Chain: A: PDB Molecule:chaperone protein hscb; PDBTitle: hsc20 (hscb), a j-type co-chaperone from e. coli Phyre2 PDB 1faf chain A Region: 96 - 130 Aligned: 34 Modelled: 35 Confidence: 70.2% Identity: 32% Fold: Long alpha-hairpin Superfamily: Chaperone J-domain Family: Chaperone J-domain Phyre2 PDB 1fpo chain A domain 1 Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 68.0% Identity: 33% Fold: Long alpha-hairpin Superfamily: Chaperone J-domain Family: Chaperone J-domain Phyre2 PDB 2ctr chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 67.8% Identity: 18% PDB header:chaperone Chain: A: PDB Molecule:dnaj homolog subfamily b member 9; PDBTitle: solution structure of j-domain from human dnaj subfamily b2 menber 9 Phyre2 PDB 1bq0 chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 67.1% Identity: 27% PDB header:chaperone Chain: A: PDB Molecule:dnaj; PDBTitle: j-domain (residues 1-77) of the escherichia coli n-terminal2 fragment (residues 1-104) of the molecular chaperone dnaj,3 nmr, 20 structures Phyre2 PDB 2ctq chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 66.2% Identity: 30% PDB header:chaperone Chain: A: PDB Molecule:dnaj homolog subfamily c member 12; PDBTitle: solution structure of j-domain from human dnaj subfamily c2 menber 12 Phyre2 PDB 2ctp chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 65.7% Identity: 33% PDB header:chaperone Chain: A: PDB Molecule:dnaj homolog subfamily b member 12; PDBTitle: solution structure of j-domain from human dnaj subfamily b2 menber 12 Phyre2 PDB 2pf4 chain E Region: 98 - 130 Aligned: 29 Modelled: 33 Confidence: 65.0% Identity: 21% PDB header:hydrolase regulator/viral protein Chain: E: PDB Molecule:small t antigen; PDBTitle: crystal structure of the full-length simian virus 40 small t antigen2 complexed with the protein phosphatase 2a aalpha subunit Phyre2 PDB 2yua chain A Region: 98 - 130 Aligned: 33 Modelled: 33 Confidence: 63.7% Identity: 21% PDB header:chaperone Chain: A: PDB Molecule:williams-beuren syndrome chromosome region 18 PDBTitle: solution structure of the dnaj domain from human williams-2 beuren syndrome chromosome region 18 protein Phyre2 1 d1qnta2 2 c2guzO_ 3 c3hhoA_ 4 c3bvoA_ 5 c2ochA_ 6 c2o37A_ 7 c2guzD_ 8 d1gh6a_ 9 d1xbla_ 10 d1hdja_ 11 c2lgwA_ 12 c1fpoA_ 13 d1fafa_ 14 d1fpoa1 15 c2ctrA_ 16 c1bq0A_ 17 c2ctqA_ 18 c2ctpA_ 19 c2pf4E_ 20 c2yuaA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63